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In Vitro Metabolism of 2-Acetylbenzothiophene: Relevance to Zileuton Hepatotoxicity

Chemical research in toxicology, 2004-02, Vol.17 (2), p.137-143

2004

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Solvent and in situ catalyst preparation impacts upon Noyori reductions of aryl-chloromethyl ketones: application to syntheses of chiral 2-amino-1-aryl-ethanols

Tetrahedron: asymmetry, 2006-08, Vol.17 (14), p.2154-2182

2006

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Identification, synthesis and SAR of amino substituted pyrido[3,2b]pyrazinones as potent and selective PDE5 inhibitors

Bioorganic & medicinal chemistry letters, 2009-08, Vol.19 (15), p.4088-4091

2009

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Investigation of aminopyridiopyrazinones as PDE5 inhibitors: Evaluation of modifications to the central ring system

Bioorganic & medicinal chemistry letters, 2009-08, Vol.19 (15), p.4092-4096

2009

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Optimization of the aminopyridopyrazinones class of PDE5 inhibitors: Discovery of 3-[( trans-4-hydroxycyclohexyl)amino]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4- b]pyrazin-2(1 H)-one

Bioorganic & medicinal chemistry letters, 2009-09, Vol.19 (17), p.5209-5213

2009

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Addition of Bromine Chloride and Iodine Monochloride to Carbonyl-Conjugated, Acetylenic Ketones: Synthesis and Mechanisms

Journal of organic chemistry, 2002-04, Vol.67 (7), p.2183-2187

2002

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A Reinvestigation of the Synthesis of Hantzsch's Acid: Comparison of Derivatives of Hantzsch's Acid with a Product from the Reaction of 2,4,6-Trichlorophenol and Hypochlorite Ion in Methanol

Journal of organic chemistry, 2000-11, Vol.65 (23), p.8111-8113

2000

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Ionic Reaction of Halogens with Terminal Alkenes: The Effect of Electron-Withdrawing Fluorine Substituents on the Bonding of Halonium Ions

Journal of organic chemistry, 2003-05, Vol.68 (10), p.3932-3937

2003

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Formation of Dimer-Type Ketals in the Reaction of 2,4,6-Trichlorophenol and 2,4,6-Trichloro-m-cresol with Calcium Hypochlorite in Methanol: Conversion to Quinones and Other Compounds

Journal of organic chemistry, 2002-09, Vol.67 (19), p.6827-6830

2002

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Reactions of Carbonyl-Conjugated Alkynes with N-Bromosuccinimide and N-Iodosuccinimide in DMF/H2O and Methanol/Sulfuric Acid: Syntheses of Dihalo Diketones, Dihalo Ketoesters, and Dihalo Acetals

Journal of organic chemistry, 1998-06, Vol.63 (13), p.4433-4437

1998

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Comparison of the electrophilic and free-radical addition of halogens with hexafluoro-1,3-butadiene and 1,3-butadiene

Journal of fluorine chemistry, 2003-10, Vol.123 (2), p.171-176

2003

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Symmetry of chloronium ions from ionic reaction of chlorine, chlorine monofluoride gas, and chlorine monofluoride complex with terminal alkenes

Journal of fluorine chemistry, 2003-11, Vol.124 (1), p.17-20

2003

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Generation of Interhalogen Fluorides under Mild Conditions: A Comparison of Sluggish and Reactive Interhalogen Fluorides

Journal of organic chemistry, 1999-02, Vol.64 (4), p.1094-1098

1999

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Investigations of the structure and reactions of the intermediate in the chlorination of resorcinol

Environmental toxicology and chemistry, 1993-09, Vol.12 (9), p.1653-1659

1993

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Determination of Ibuprofen Vapor Pressure at Temperatures of Pharmaceutical Interest

Journal of pharmaceutical sciences, 1990-06, Vol.79 (6), p.552-552

1990

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Effect of N-bromosuccinimide (NBS) and other N-brominating agents on the bromination of .alpha.,.beta.-unsaturated ketones in methanol

Journal of organic chemistry, 1988-05, Vol.53 (10), p.2199-2204

1988

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Electrophilic versus free radical reactions of halogens and halogen systems with perfluoroalkenes and a perfluoroalkylethylene

Journal of fluorine chemistry, 2000-10, Vol.106 (1), p.103-112

2000

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Reactions of terminal alkynes with iodine in methanol

Journal of organic chemistry, 1980-11, Vol.45 (23), p.4649-4652

1980

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Benchtop synthesis and characterization of air-stable titanocene(IV) complexes from phosphorous- and sulfur-based amino acid analogs

Tetrahedron letters, 1999-08, Vol.40 (35), p.6333-6337

1999

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Addition of tert-butyl hypoiodite to selected olefins

Journal of organic chemistry, 1988-01, Vol.53 (1), p.198-201

1988

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Fluorination of 1,3-dienes with xenon difluoride and (difluoroiodo)benzene

Journal of organic chemistry, 1984-12, Vol.49 (25), p.5015-5018

1984

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Regioselective chemistry of methoxyxenon fluoride

Journal of organic chemistry, 1985-07, Vol.50 (15), p.2751-2758

1985

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Chlorination of 1-hexyne and 3-hexyne in acetic acid and methanol

Journal of organic chemistry, 1985-05, Vol.50 (10), p.1773-1776

1985

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Facile Addition of Poorly Nucleophilic Alcohols to Unactivated Alkenes

Synthesis (Stuttgart), 1997-09, Vol.1997 (9), p.1056-1060

Shellhamer, Dale F.

1997

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Boron trifluoride promoted reaction of alkyl hypohalites with alkenes. A new synthesis of fluoro halides

Journal of organic chemistry, 1983-09, Vol.48 (19), p.3195-3199

1983

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In Vitro Metabolism of 2-Acetylbenzothiophene: Relevance to Zileuton Hepatotoxicity

Solvent and in situ catalyst preparation impacts upon Noyori reductions of aryl-chloromethyl ketones: application to syntheses of chiral 2-amino-1-aryl-ethanols

Identification, synthesis and SAR of amino substituted pyrido[3,2b]pyrazinones as potent and selective PDE5 inhibitors

Investigation of aminopyridiopyrazinones as PDE5 inhibitors: Evaluation of modifications to the central ring system

Optimization of the aminopyridopyrazinones class of PDE5 inhibitors: Discovery of 3-[( trans-4-hydroxycyclohexyl)amino]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4- b]pyrazin-2(1 H)-one

Addition of Bromine Chloride and Iodine Monochloride to Carbonyl-Conjugated, Acetylenic Ketones: Synthesis and Mechanisms

A Reinvestigation of the Synthesis of Hantzsch's Acid: Comparison of Derivatives of Hantzsch's Acid with a Product from the Reaction of 2,4,6-Trichlorophenol and Hypochlorite Ion in Methanol

Ionic Reaction of Halogens with Terminal Alkenes: The Effect of Electron-Withdrawing Fluorine Substituents on the Bonding of Halonium Ions

Formation of Dimer-Type Ketals in the Reaction of 2,4,6-Trichlorophenol and 2,4,6-Trichloro-m-cresol with Calcium Hypochlorite in Methanol: Conversion to Quinones and Other Compounds

Reactions of Carbonyl-Conjugated Alkynes with N-Bromosuccinimide and N-Iodosuccinimide in DMF/H2O and Methanol/Sulfuric Acid: Syntheses of Dihalo Diketones, Dihalo Ketoesters, and Dihalo Acetals

Comparison of the electrophilic and free-radical addition of halogens with hexafluoro-1,3-butadiene and 1,3-butadiene

Symmetry of chloronium ions from ionic reaction of chlorine, chlorine monofluoride gas, and chlorine monofluoride complex with terminal alkenes

Generation of Interhalogen Fluorides under Mild Conditions: A Comparison of Sluggish and Reactive Interhalogen Fluorides

Investigations of the structure and reactions of the intermediate in the chlorination of resorcinol

Determination of Ibuprofen Vapor Pressure at Temperatures of Pharmaceutical Interest

Effect of N-bromosuccinimide (NBS) and other N-brominating agents on the bromination of .alpha.,.beta.-unsaturated ketones in methanol

Electrophilic versus free radical reactions of halogens and halogen systems with perfluoroalkenes and a perfluoroalkylethylene

Reactions of terminal alkynes with iodine in methanol

Benchtop synthesis and characterization of air-stable titanocene(IV) complexes from phosphorous- and sulfur-based amino acid analogs

Addition of tert-butyl hypoiodite to selected olefins

Fluorination of 1,3-dienes with xenon difluoride and (difluoroiodo)benzene

Regioselective chemistry of methoxyxenon fluoride

Chlorination of 1-hexyne and 3-hexyne in acetic acid and methanol

Facile Addition of Poorly Nucleophilic Alcohols to Unactivated Alkenes

Boron trifluoride promoted reaction of alkyl hypohalites with alkenes. A new synthesis of fluoro halides

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