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Optimization of a Tertiary Alcohol Series of Phosphodiesterase-4 (PDE4) Inhibitors: Structure−Activity Relationship Related to PDE4 Inhibition and Human Ether-a-go-go Related Gene Potassium Channel Binding Affinity

Journal of medicinal chemistry, 2003-06, Vol.46 (12), p.2413-2426

2003

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Potent, orally active imidazo[4,5-b]pyridine-based angiotensin II receptor antagonists

Journal of medicinal chemistry, 1991-09, Vol.34 (9), p.2919-2922

1991

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Design and synthesis of P2-P1'-linked macrocyclic human renin inhibitors

Journal of medicinal chemistry, 1991-09, Vol.34 (9), p.2692-2701

1991

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(Dipropylphenoxy)phenylacetic acids: a new generation of nonpeptide angiotensin II receptor antagonists

Journal of medicinal chemistry, 1993-11, Vol.36 (23), p.3738-3742

1993

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Renin inhibitors containing C-termini derived from mercaptoheterocycles

Journal of medicinal chemistry, 1992-05, Vol.35 (11), p.2103-2112

1992

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Renin inhibitors containing conformationally restricted P1-P1' dipeptide mimetics

Journal of medicinal chemistry, 1991-03, Vol.34 (3), p.887-900

1991

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Inhibitors of human renin with C-termini derived from amides and esters of .alpha.-mercaptoalkanoic acids

Journal of medicinal chemistry, 1992-07, Vol.35 (15), p.2772-2781

1992

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Models used to assess cardiovascular function in general pharmacology

Drug development research, 1994-08, Vol.32 (4), p.256-259

1994

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Nonpeptide angiotensin II antagonists derived from 1H-pyrazole-5-carboxylates and 4-aryl-1H-imidazole-5-carboxylates

Journal of medicinal chemistry, 1993-11, Vol.36 (23), p.3595-3605

1993

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Nonpeptide angiotensin II antagonists derived from 4H-1,2,4-triazoles and 3H-imidazo[1,2-b][1,2,4]triazoles

Journal of medicinal chemistry, 1993-03, Vol.36 (5), p.591-609

1993

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Actions of Mescaline on Isolated Rat Atria

Journal of pharmaceutical sciences, 1977-07, Vol.66 (7), p.938-941

1977

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Angiotensin II receptor antagonists containing a phenylpyridine element

Bioorganic & medicinal chemistry letters, 1993-08, Vol.3 (8), p.1693-1696

1993

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Triazolinones as nonpeptide angiotensin II antagonists. 1. Synthesis and evaluation of potent 2,4,5-trisubstituted triazolinones

Journal of medicinal chemistry, 1993-08, Vol.36 (17), p.2558-2568

1993

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Highly potent, orally active diester macrocyclic human renin inhibitors

Journal of medicinal chemistry, 1992-10, Vol.35 (21), p.3755-3773

1992

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Synthesis of new imidazo[1,2- b]pyridazine isosteres of potent imidazo[4,5- b]pyridine angiotensin II antagonists

Bioorganic & medicinal chemistry letters, 1994-01, Vol.4 (1), p.219-222

1994

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Quinazolinone Biphenyl Acylsulfonamides: A potent new class of angiotensin-II receptor antagonists

Bioorganic & medicinal chemistry letters, 1994-01, Vol.4 (1), p.75-80

1994

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Optimization of a Tertiary Alcohol Series of Phosphodiesterase-4 (PDE4) Inhibitors: Structure−Activity Relationship Related to PDE4 Inhibition and Human Ether-a-go-go Related Gene Potassium Channel Binding Affinity

Potent, orally active imidazo[4,5-b]pyridine-based angiotensin II receptor antagonists

Class III Antiarrhythmic Activity in Vivo by Selective Blockade of the Slowly Activating Cardiac Delayed Rectifier Potassium Current I Ks by (R)-2-(2,4- Trifluoromethyl)-N-[2-oxo-5-phenyl- 1-(2,2,2-trifluoroethyl)-2,3-dihydro- 1H-benzo[e][1,4]diazepin-3-yl]acetamide

Design and synthesis of P2-P1'-linked macrocyclic human renin inhibitors

(Dipropylphenoxy)phenylacetic acids: a new generation of nonpeptide angiotensin II receptor antagonists

Renin inhibitors containing C-termini derived from mercaptoheterocycles

Renin inhibitors containing conformationally restricted P1-P1' dipeptide mimetics

Inhibitors of human renin with C-termini derived from amides and esters of .alpha.-mercaptoalkanoic acids

Models used to assess cardiovascular function in general pharmacology

Nonpeptide angiotensin II antagonists derived from 1H-pyrazole-5-carboxylates and 4-aryl-1H-imidazole-5-carboxylates

Nonpeptide angiotensin II antagonists derived from 4H-1,2,4-triazoles and 3H-imidazo[1,2-b][1,2,4]triazoles

Actions of Mescaline on Isolated Rat Atria

Angiotensin II receptor antagonists containing a phenylpyridine element

Triazolinones as nonpeptide angiotensin II antagonists. 1. Synthesis and evaluation of potent 2,4,5-trisubstituted triazolinones

Highly potent, orally active diester macrocyclic human renin inhibitors

Synthesis of new imidazo[1,2- b]pyridazine isosteres of potent imidazo[4,5- b]pyridine angiotensin II antagonists

Quinazolinone Biphenyl Acylsulfonamides: A potent new class of angiotensin-II receptor antagonists

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