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Optimization of isochromanone based urotensin II receptor agonists

Bioorganic & medicinal chemistry, 2010-07, Vol.18 (13), p.4844-4854

2010

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Design, parallel synthesis and SAR of novel urotensin II receptor agonists

European journal of medicinal chemistry, 2007-02, Vol.42 (2), p.276-285

2007

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Design, Synthesis, and Structure−Activity Analysis of Isoform-Selective Retinoic Acid Receptor β Ligands

Journal of medicinal chemistry, 2009-03, Vol.52 (6), p.1540-1545

2009

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Novel Potent and Efficacious Nonpeptidic Urotensin II Receptor Agonists

Journal of medicinal chemistry, 2006-04, Vol.49 (7), p.2232-2240

2006

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3-Heteroaryl-Substituted Quinuclidin-3-ol and Quinuclidin-2-ene Derivatives as Muscarinic Antagonists. Synthesis and Structure-Activity Relationships

Journal of medicinal chemistry, 1995-02, Vol.38 (3), p.473-487

1995

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Isochromanone-based urotensin-II receptor agonists

Bioorganic & medicinal chemistry, 2005-04, Vol.13 (8), p.3057-3068

2005

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Novel and potent small-molecule urotensin II receptor agonists

Bioorganic & medicinal chemistry, 2009-07, Vol.17 (13), p.4657-4665

2009

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Discovery of the First Nonpeptide Agonist of the GPR14/Urotensin-II Receptor: 3-(4-Chlorophenyl)-3-(2- (dimethylamino)ethyl)isochroman-1-one (AC-7954)

Journal of medicinal chemistry, 2002-11, Vol.45 (23), p.4950-4953

2002

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Binding-site modeling of the muscarinic m1 receptor: a combination of homology-based and indirect approaches

Journal of medicinal chemistry, 1993-04, Vol.36 (8), p.967-976

1993

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Atropisomeric Derivatives of 2‘,6‘-Disubstituted (R)-11-Phenylaporphine: Selective Serotonin 5-HT7 Receptor Antagonists

Journal of medicinal chemistry, 2001-04, Vol.44 (9), p.1337-1340

2001

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Derivatives of (R)-1,11-Methyleneaporphine: Synthesis, Structure, and Interactions with G-Protein Coupled Receptors

Journal of medicinal chemistry, 2000-04, Vol.43 (7), p.1339-1349

2000

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Synthesis and pharmacology of the enantiomers of cis-7-hydroxy-3-methyl-2-(dipropylamino)tetralin

Journal of medicinal chemistry, 1990-10, Vol.33 (10), p.2925-2929

1990

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Phenyl-substituted analogs of oxotremorine as muscarinic antagonists

Journal of medicinal chemistry, 1992-01, Vol.35 (2), p.285-294

1992

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Characterization of the Binding Site of the Histamine H 3 Receptor. 1. Various Approaches to the Synthesis of 2-(1 H -Imidazol-4-yl)cyclopropylamine and Histaminergic Activity of (1 R ,2 R )- and (1 S ,2 S )-2-(1 H -Imidazol-4-yl)- cyclopropylamine

Journal of medicinal chemistry, 1999-04, Vol.42 (7), p.1115-1122

1999

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Derivatives of 17-phenyl-18,19,20-trinorprostaglandin F2α isopropyl ester : potential antiglaucoma agents

Journal of medicinal chemistry, 1995-01, Vol.38 (2), p.289-304

1995

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Antimuscarinic 3-(2-Furanyl)quinuclidin-2-ene Derivatives: Synthesis and Structure−Activity Relationships

Journal of medicinal chemistry, 1997-11, Vol.40 (23), p.3804-3819

1997

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trans-2-Aryl-N,N-dipropylcyclopropylamines: Synthesis and Interactions with 5-HT1A Receptors

Journal of medicinal chemistry, 1996-03, Vol.39 (7), p.1485-1493

1996

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3-(2-Benzofuranyl)quinuclidin-2-ene Derivatives: Novel Muscarinic Antagonists

Journal of medicinal chemistry, 1996-08, Vol.39 (17), p.3269-3277

1996

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3-Lithioquinuclidin-2-ene: A novel intermediate for the synthesis of muscarinic agonists and antagonists

Bioorganic & medicinal chemistry letters, 1994-12, Vol.4 (24), p.2837-2840

1994

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Derivatives of 2-(dipropylamino)tetralin: effect of the C8-substituent on the interaction with 5-HT1A receptors

Journal of medicinal chemistry, 1993-12, Vol.36 (26), p.4221-4229

1993

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A 3-D model for 5-HT1A-receptor agonists based on stereoselective methyl-substituted and conformationally restricted analogues of 8-hydroxy-2-(dipropylamino)tetralin

Journal of medicinal chemistry, 1991-02, Vol.34 (2), p.497-510

1991

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(S)-5-fluoro-8-hydroxy-2-(dipropylamino)tetralin: a putative 5-HT1A-receptor antagonist

Journal of medicinal chemistry, 1990-06, Vol.33 (6), p.1541-1544

1990

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Derivatives of 2-arylcyclopropylamine: Synthesis and interactions with 5-HT1A receptors

Bioorganic & medicinal chemistry letters, 1996-02, Vol.6 (4), p.415-420

1996

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Novel (R)-2-Amino-5-fluorotetralins: Dopaminergic Antagonists and Inverse Agonists

Journal of medicinal chemistry, 1996-10, Vol.39 (22), p.4421-4429

1996

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Stereoisomers of 3-(2,3-dihydrobenzofuran-2-yl)quinuclidine: Preparation and muscarinic receptor affinities

Chirality (New York, N.Y.), 1998, Vol.10 (9), p.813-820

1998

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Optimization of isochromanone based urotensin II receptor agonists

Design, parallel synthesis and SAR of novel urotensin II receptor agonists

Design, Synthesis, and Structure−Activity Analysis of Isoform-Selective Retinoic Acid Receptor β Ligands

Novel Potent and Efficacious Nonpeptidic Urotensin II Receptor Agonists

3-Heteroaryl-Substituted Quinuclidin-3-ol and Quinuclidin-2-ene Derivatives as Muscarinic Antagonists. Synthesis and Structure-Activity Relationships

Isochromanone-based urotensin-II receptor agonists

Novel and potent small-molecule urotensin II receptor agonists

Discovery of the First Nonpeptide Agonist of the GPR14/Urotensin-II Receptor: 3-(4-Chlorophenyl)-3-(2- (dimethylamino)ethyl)isochroman-1-one (AC-7954)

Binding-site modeling of the muscarinic m1 receptor: a combination of homology-based and indirect approaches

Atropisomeric Derivatives of 2‘,6‘-Disubstituted (R)-11-Phenylaporphine: Selective Serotonin 5-HT7 Receptor Antagonists

Derivatives of (R)-1,11-Methyleneaporphine: Synthesis, Structure, and Interactions with G-Protein Coupled Receptors

Synthesis and pharmacology of the enantiomers of cis-7-hydroxy-3-methyl-2-(dipropylamino)tetralin

Phenyl-substituted analogs of oxotremorine as muscarinic antagonists

Characterization of the Binding Site of the Histamine H 3 Receptor. 1. Various Approaches to the Synthesis of 2-(1 H -Imidazol-4-yl)cyclopropylamine and Histaminergic Activity of (1 R ,2 R )- and (1 S ,2 S )-2-(1 H -Imidazol-4-yl)- cyclopropylamine

Derivatives of 17-phenyl-18,19,20-trinorprostaglandin F2α isopropyl ester : potential antiglaucoma agents

Antimuscarinic 3-(2-Furanyl)quinuclidin-2-ene Derivatives: Synthesis and Structure−Activity Relationships

trans-2-Aryl-N,N-dipropylcyclopropylamines: Synthesis and Interactions with 5-HT1A Receptors

3-(2-Benzofuranyl)quinuclidin-2-ene Derivatives: Novel Muscarinic Antagonists

3-Lithioquinuclidin-2-ene: A novel intermediate for the synthesis of muscarinic agonists and antagonists

Derivatives of 2-(dipropylamino)tetralin: effect of the C8-substituent on the interaction with 5-HT1A receptors

A 3-D model for 5-HT1A-receptor agonists based on stereoselective methyl-substituted and conformationally restricted analogues of 8-hydroxy-2-(dipropylamino)tetralin

(S)-5-fluoro-8-hydroxy-2-(dipropylamino)tetralin: a putative 5-HT1A-receptor antagonist

Derivatives of 2-arylcyclopropylamine: Synthesis and interactions with 5-HT1A receptors

Novel (R)-2-Amino-5-fluorotetralins: Dopaminergic Antagonists and Inverse Agonists

Stereoisomers of 3-(2,3-dihydrobenzofuran-2-yl)quinuclidine: Preparation and muscarinic receptor affinities

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