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Global genomic and transcriptomic analysis of human pancreatic islets reveals novel genes influencing glucose metabolism

Proceedings of the National Academy of Sciences - PNAS, 2014-09, Vol.111 (38), p.13924-13929

2014

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A Systems Genetics Approach Identifies Genes and Pathways for Type 2 Diabetes in Human Islets

Cell metabolism, 2012-07, Vol.16 (1), p.122-134

2012

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Elevated miR-130a/miR130b/miR-152 expression reduces intracellular ATP levels in the pancreatic beta cell

Scientific reports, 2017-03, Vol.7 (1), p.44986-44986, Article 44986

2017

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Glutamine-Elicited Secretion of Glucagon-Like Peptide 1 Is Governed by an Activated Glutamate Dehydrogenase

Diabetes (New York, N.Y.), 2018-03, Vol.67 (3), p.372-384

2018

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Inhibition of the malate-aspartate shuttle in mouse pancreatic islets abolishes glucagon secretion without affecting insulin secretion

Biochemical journal, 2015-05, Vol.468 (1), p.49-63

2015

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Sulforaphane reduces hepatic glucose production and improves glucose control in patients with type 2 diabetes

Science translational medicine, 2017-06, Vol.9 (394)

2017

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The HNF-1 target Collectrin controls insulin exocytosis by SNARE complex formation

Cell metabolism, 2005-12, Vol.2 (6), p.373-384

2005

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Epigallocatechin-3-gallate (EGCG) activates AMPK through the inhibition of glutamate dehydrogenase in muscle and pancreatic ß-cells: A potential beneficial effect in the pre-diabetic state?

The international journal of biochemistry & cell biology, 2017-07, Vol.88, p.220-225

2017

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Synaptotagmin V and IX isoforms control Ca2+ -dependent insulin exocytosis

Journal of cell science, 2004-07, Vol.117 (Pt 15), p.3119-3127

2004

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ER stress and SREBP-1 activation are implicated in beta-cell glucolipotoxicity

Journal of cell science, 2005-09, Vol.118 (Pt 17), p.3905-3915

2005

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Inhibition of Mitochondrial Na+-Ca2+ Exchanger Increases Mitochondrial Metabolism and Potentiates Glucose-Stimulated Insulin Secretion in Rat Pancreatic Islets

Diabetes (New York, N.Y.), 2003-04, Vol.52 (4), p.965-973

2003

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Dynamin-related protein 1 mediates high glucose induced pancreatic beta cell apoptosis

The international journal of biochemistry & cell biology, 2009-04, Vol.41 (4), p.879-890

2009

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Mitochondrial matrix pH controls oxidative phosphorylation and metabolism-secretion coupling in INS-1E clonal β cells

The FASEB journal, 2010-11, Vol.24 (11), p.4613-4626

2010

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Transcriptional Regulation of X-Box-binding Protein One (XBP1) by Hepatocyte Nuclear Factor 4α (HNF4Α) Is Vital to Beta-cell Function

The Journal of biological chemistry, 2016-03, Vol.291 (12), p.6146-6157

2016

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Hydrogen Peroxide Alters Mitochondrial Activation and Insulin Secretion in Pancreatic Beta Cells

The Journal of biological chemistry, 1999-09, Vol.274 (39), p.27905-27913

1999

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Evidence against a direct role of klotho in insulin resistance

Pflügers Archiv, 2010-02, Vol.459 (3), p.465-473

2010

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Synaptotagmin VII splice variants α, β, and δ are expressed in pancreatic β-cells and regulate insulin exocytosis

The FASEB journal, 2008, Vol.22 (1), p.194-206

2008

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Pdx1 Level Defines Pancreatic Gene Expression Pattern and Cell Lineage Differentiation

The Journal of biological chemistry, 2001-07, Vol.276 (27), p.25279-25286

2001

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Adenovirus‐mediated silencing of Synaptotagmin 9 inhibits Ca2+‐dependent insulin secretion in islets

FEBS letters, 2005-09, Vol.579 (23), p.5241-5246

2005

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Human Krüppel-like factor 11 differentially regulates human insulin promoter activity in β-cells and non-β-cells via p300 and PDX1 through the regulatory sites A3 and CACCC box

Molecular and cellular endocrinology, 2012-11, Vol.363 (1-2), p.20-26

2012

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SV2A and SV2C are not vesicular Ca²⁺ transporters but control glucose-evoked granule recruitment

Journal of cell science, 2005-12, Vol.118 (23), p.5647-5660

2005

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Mitochondrial metabolism sets the maximal limit of fuel-stimulated insulin secretion in a model pancreatic beta cell: a survey of four fuel secretagogues

The Journal of biological chemistry, 2002-04, Vol.277 (14), p.11746

2002

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Early activation of the fatty acid metabolism pathway by chronic high glucose exposure in rat insulin secretory β-cells

Proteomics (Weinheim), 2010, Vol.10 (1), p.59-71

2010

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Molecular targets of a human HNF1α mutation responsible for pancreatic β-cell dysfunction

The EMBO journal, 2000-08, Vol.19 (16), p.4257-4264

2000

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Mitochondrial activation directly triggers the exocytosis of insulin in permeabilized pancreatic β-cells

The EMBO journal, 1997-07, Vol.16 (13), p.3833-3841

1997

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Global genomic and transcriptomic analysis of human pancreatic islets reveals novel genes influencing glucose metabolism

A Systems Genetics Approach Identifies Genes and Pathways for Type 2 Diabetes in Human Islets

Elevated miR-130a/miR130b/miR-152 expression reduces intracellular ATP levels in the pancreatic beta cell

Glutamine-Elicited Secretion of Glucagon-Like Peptide 1 Is Governed by an Activated Glutamate Dehydrogenase

Inhibition of the malate-aspartate shuttle in mouse pancreatic islets abolishes glucagon secretion without affecting insulin secretion

Sulforaphane reduces hepatic glucose production and improves glucose control in patients with type 2 diabetes

The HNF-1 target Collectrin controls insulin exocytosis by SNARE complex formation

Epigallocatechin-3-gallate (EGCG) activates AMPK through the inhibition of glutamate dehydrogenase in muscle and pancreatic ß-cells: A potential beneficial effect in the pre-diabetic state?

Synaptotagmin V and IX isoforms control Ca2+ -dependent insulin exocytosis

ER stress and SREBP-1 activation are implicated in beta-cell glucolipotoxicity

Inhibition of Mitochondrial Na+-Ca2+ Exchanger Increases Mitochondrial Metabolism and Potentiates Glucose-Stimulated Insulin Secretion in Rat Pancreatic Islets

Dynamin-related protein 1 mediates high glucose induced pancreatic beta cell apoptosis

Mitochondrial matrix pH controls oxidative phosphorylation and metabolism-secretion coupling in INS-1E clonal β cells

Transcriptional Regulation of X-Box-binding Protein One (XBP1) by Hepatocyte Nuclear Factor 4α (HNF4Α) Is Vital to Beta-cell Function

Hydrogen Peroxide Alters Mitochondrial Activation and Insulin Secretion in Pancreatic Beta Cells

Evidence against a direct role of klotho in insulin resistance

Synaptotagmin VII splice variants α, β, and δ are expressed in pancreatic β-cells and regulate insulin exocytosis

Pdx1 Level Defines Pancreatic Gene Expression Pattern and Cell Lineage Differentiation

Adenovirus‐mediated silencing of Synaptotagmin 9 inhibits Ca2+‐dependent insulin secretion in islets

Human Krüppel-like factor 11 differentially regulates human insulin promoter activity in β-cells and non-β-cells via p300 and PDX1 through the regulatory sites A3 and CACCC box

SV2A and SV2C are not vesicular Ca²⁺ transporters but control glucose-evoked granule recruitment

Mitochondrial metabolism sets the maximal limit of fuel-stimulated insulin secretion in a model pancreatic beta cell: a survey of four fuel secretagogues

Early activation of the fatty acid metabolism pathway by chronic high glucose exposure in rat insulin secretory β-cells

Molecular targets of a human HNF1α mutation responsible for pancreatic β-cell dysfunction

Mitochondrial activation directly triggers the exocytosis of insulin in permeabilized pancreatic β-cells

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