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7,8-Disubstituted- but not 6,7-disubstituted coumarins selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic ones I and II in the low nanomolar/subnanomolar range

Bioorganic & medicinal chemistry letters, 2010-12, Vol.20 (24), p.7255-7258

2010

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Synthesis and biological evaluation of novel aromatic and heterocyclic bis-sulfonamide Schiff bases as carbonic anhydrase I, II, VII and IX inhibitors

Bioorganic & medicinal chemistry, 2017-06, Vol.25 (12), p.3093-3097

2017

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Synthesis and biological evaluation of benzenesulphonamide-bearing 1,4,5-trisubstituted-1,2,3-triazoles possessing human carbonic anhydrase I, II, IV, and IX inhibitory activity

Journal of enzyme inhibition and medicinal chemistry, 2017-01, Vol.32 (1), p.1187-1194

2017

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Discovery of potent anti-convulsant carbonic anhydrase inhibitors: Design, synthesis, in vitro and in vivo appraisal

European journal of medicinal chemistry, 2018-08, Vol.156, p.430-443

2018

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6-Triazolyl-substituted sulfocoumarins are potent, selective inhibitors of the tumor-associated carbonic anhydrases IX and XII

Bioorganic & medicinal chemistry letters, 2014-03, Vol.24 (5), p.1256-1260

2014

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Synthesis and carbonic anhydrase I, II, VII, and IX inhibition studies with a series of benzo[d]thiazole-5- and 6-sulfonamides

Journal of enzyme inhibition and medicinal chemistry, 2017-01, Vol.32 (1), p.1071-1078

2017

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Synthesis of 6-tetrazolyl-substituted sulfocoumarins acting as highly potent and selective inhibitors of the tumor-associated carbonic anhydrase isoforms IX and XII

Bioorganic & medicinal chemistry, 2014-03, Vol.22 (5), p.1522-1528

2014

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Sulfocoumarin‐, Coumarin‐, 4‐Sulfamoylphenyl‐Bearing Indazole‐3‐carboxamide Hybrids: Synthesis and Selective Inhibition of Tumor‐Associated Carbonic Anhydrase Isozymes IX and XII

ChemMedChem, 2017-10, Vol.12 (19), p.1578-1584

2017

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Design and synthesis of benzothiazole-6-sulfonamides acting as highly potent inhibitors of carbonic anhydrase isoforms I, II, IX and XII

Bioorganic & medicinal chemistry, 2015-08, Vol.23 (15), p.4989-4999

2015

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Discovery of curcumin inspired sulfonamide derivatives as a new class of carbonic anhydrase isoforms I, II, IX, and XII inhibitors

Journal of enzyme inhibition and medicinal chemistry, 2017-01, Vol.32 (1), p.1274-1281

2017

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Discovery of new ureido benzenesulfonamides incorporating 1,3,5-triazine moieties as carbonic anhydrase I, II, IX and XII inhibitors

Bioorganic & medicinal chemistry, 2019-04, Vol.27 (8), p.1588-1594

2019

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Coumarins incorporating hydroxy- and chloro-moieties selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic ones I and II

Bioorganic & medicinal chemistry letters, 2010-08, Vol.20 (15), p.4511-4514

2010

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New Histamine-Related Five-Membered N-Heterocycle Derivatives as Carbonic Anhydrase I Activators

Molecules (Basel, Switzerland), 2022-01, Vol.27 (2), p.545

2022

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Design, synthesis and molecular modelling studies of some pyrazole derivatives as carbonic anhydrase inhibitors

Journal of enzyme inhibition and medicinal chemistry, 2020-01, Vol.35 (1), p.289-297

2020

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Cloning, expression, purification and sulfonamide inhibition profile of the complete domain of the η-carbonic anhydrase from Plasmodium falciparum

Bioorganic & medicinal chemistry letters, 2016-09, Vol.26 (17), p.4184-4190

2016

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Novel sulphonamides incorporating triazene moieties show powerful carbonic anhydrase I and II inhibitory properties

Journal of enzyme inhibition and medicinal chemistry, 2020-01, Vol.35 (1), p.325-329

2020

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Versatile Diazomethane Sulfonamide for Expedited Exploration of Azole‐Based Carbonic Anhydrase Inhibitors via [3+2] Cycloaddition

ChemMedChem, 2023-05, Vol.18 (10), p.e202200607-n/a

2023

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Carbonic Anhydrase Inhibitors and Epilepsy: State of the Art and Future Perspectives

Molecules (Basel, Switzerland), 2021-10, Vol.26 (21), p.6380

2021

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Synthesis, characterisation, biological evaluation and in silico studies of sulphonamide Schiff bases

Journal of enzyme inhibition and medicinal chemistry, 2020-01, Vol.35 (1), p.950-962

2020

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Investigation of novel alkyl/benzyl (4-sulphamoylphenyl)carbamimidothioates as carbonic anhydrase inhibitors

Journal of enzyme inhibition and medicinal chemistry, 2023-12, Vol.38 (1), p.2152811-2152811

2023

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Sulfonamides incorporating 1,3,5-triazine moieties selectively and potently inhibit carbonic anhydrase transmembrane isoforms IX, XII and XIV over cytosolic isoforms I and II: Solution and X-ray crystallographic studies

Bioorganic & medicinal chemistry, 2011-05, Vol.19 (10), p.3105-3119

2011

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Novel sulfonamide incorporating piperazine, aminoalcohol and 1,3,5-triazine structural motifs with carbonic anhydrase I, II and IX inhibitory action

Bioorganic chemistry, 2018-04, Vol.77, p.25-37

2018

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Iodine/Oxone® oxidative system for the synthesis of selenylindoles bearing a benzenesulfonamide moiety as carbonic anhydrase I, II, IX, and XII inhibitors

Organic & biomolecular chemistry, 2024-08, Vol.22 (32), p.6532-6542

2024

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Synthetic Strategies and Computational Inhibition Activity Study for Triazinyl-Substituted Benzenesulfonamide Conjugates with Polar and Hydrophobic Amino Acids as Inhibitors of Carbonic Anhydrases

International journal of molecular sciences, 2020-05, Vol.21 (10), p.3661

2020

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Organoruthenium(II) complexes of acetazolamide potently inhibit human carbonic anhydrase isoforms I, II, IX and XII

Journal of enzyme inhibition and medicinal chemistry, 2019-01, Vol.34 (1), p.388-393

2019

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7,8-Disubstituted- but not 6,7-disubstituted coumarins selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic ones I and II in the low nanomolar/subnanomolar range

Synthesis and biological evaluation of novel aromatic and heterocyclic bis-sulfonamide Schiff bases as carbonic anhydrase I, II, VII and IX inhibitors

Synthesis and biological evaluation of benzenesulphonamide-bearing 1,4,5-trisubstituted-1,2,3-triazoles possessing human carbonic anhydrase I, II, IV, and IX inhibitory activity

Discovery of potent anti-convulsant carbonic anhydrase inhibitors: Design, synthesis, in vitro and in vivo appraisal

6-Triazolyl-substituted sulfocoumarins are potent, selective inhibitors of the tumor-associated carbonic anhydrases IX and XII

Synthesis and carbonic anhydrase I, II, VII, and IX inhibition studies with a series of benzo[d]thiazole-5- and 6-sulfonamides

Synthesis of 6-tetrazolyl-substituted sulfocoumarins acting as highly potent and selective inhibitors of the tumor-associated carbonic anhydrase isoforms IX and XII

Sulfocoumarin‐, Coumarin‐, 4‐Sulfamoylphenyl‐Bearing Indazole‐3‐carboxamide Hybrids: Synthesis and Selective Inhibition of Tumor‐Associated Carbonic Anhydrase Isozymes IX and XII

Design and synthesis of benzothiazole-6-sulfonamides acting as highly potent inhibitors of carbonic anhydrase isoforms I, II, IX and XII

Discovery of curcumin inspired sulfonamide derivatives as a new class of carbonic anhydrase isoforms I, II, IX, and XII inhibitors

Discovery of new ureido benzenesulfonamides incorporating 1,3,5-triazine moieties as carbonic anhydrase I, II, IX and XII inhibitors

Coumarins incorporating hydroxy- and chloro-moieties selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic ones I and II

New Histamine-Related Five-Membered N-Heterocycle Derivatives as Carbonic Anhydrase I Activators

Design, synthesis and molecular modelling studies of some pyrazole derivatives as carbonic anhydrase inhibitors

Cloning, expression, purification and sulfonamide inhibition profile of the complete domain of the η-carbonic anhydrase from Plasmodium falciparum

Novel sulphonamides incorporating triazene moieties show powerful carbonic anhydrase I and II inhibitory properties

Versatile Diazomethane Sulfonamide for Expedited Exploration of Azole‐Based Carbonic Anhydrase Inhibitors via [3+2] Cycloaddition

Carbonic Anhydrase Inhibitors and Epilepsy: State of the Art and Future Perspectives

Synthesis, characterisation, biological evaluation and in silico studies of sulphonamide Schiff bases

Investigation of novel alkyl/benzyl (4-sulphamoylphenyl)carbamimidothioates as carbonic anhydrase inhibitors

Sulfonamides incorporating 1,3,5-triazine moieties selectively and potently inhibit carbonic anhydrase transmembrane isoforms IX, XII and XIV over cytosolic isoforms I and II: Solution and X-ray crystallographic studies

Novel sulfonamide incorporating piperazine, aminoalcohol and 1,3,5-triazine structural motifs with carbonic anhydrase I, II and IX inhibitory action

Iodine/Oxone® oxidative system for the synthesis of selenylindoles bearing a benzenesulfonamide moiety as carbonic anhydrase I, II, IX, and XII inhibitors

Synthetic Strategies and Computational Inhibition Activity Study for Triazinyl-Substituted Benzenesulfonamide Conjugates with Polar and Hydrophobic Amino Acids as Inhibitors of Carbonic Anhydrases

Organoruthenium(II) complexes of acetazolamide potently inhibit human carbonic anhydrase isoforms I, II, IX and XII

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