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Multiple roles of HDAC inhibition in neurodegenerative conditions

Trends in neurosciences (Regular ed.), 2009-11, Vol.32 (11), p.591-601

2009

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Multi-target-Directed Ligands To Combat Neurodegenerative Diseases

Journal of medicinal chemistry, 2008-02, Vol.51 (3), p.347-372

2008

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RNAi: a potential new class of therapeutic for human genetic disease

Human genetics, 2011-11, Vol.130 (5), p.583-605

Seyhan, Attila A.

2011

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Tetrabenazine for the Treatment of Hyperkinetic Movement Disorders: A Review of the Literature

Clinical therapeutics, 2012-07, Vol.34 (7), p.1487-1504

2012

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The kynurenine pathway in neurodegenerative diseases: Mechanistic and therapeutic considerations

Journal of the neurological sciences, 2012-12, Vol.323 (1), p.1-8

2012

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Combination therapy with Coenzyme Q₁₀ and creatine produces additive neuroprotective effects in models of Parkinson's and Huntington's Diseases

Journal of neurochemistry, 2009-06, Vol.109 (5), p.1427-1439

2009

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Pharmacologic activation of mitochondrial biogenesis exerts widespread beneficial effects in a transgenic mouse model of Huntington's disease

Human molecular genetics, 2012-03, Vol.21 (5), p.1124-1137

2012

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Evidence-based guideline: pharmacologic treatment of chorea in Huntington disease: report of the guideline development subcommittee of the American Academy of Neurology

Neurology, 2012-08, Vol.79 (6), p.597-603

2012

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Exendin-4 Improves Glycemic Control, Ameliorates Brain and Pancreatic Pathologies, and Extends Survival in a Mouse Model of Huntington's Disease

Diabetes (New York, N.Y.), 2009-02, Vol.58 (2), p.318-328

2009

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The endocannabinoid system as a target for the treatment of motor dysfunction

British journal of pharmacology, 2009-04, Vol.156 (7), p.1029-1040

Fernández‐Ruiz, Javier

2009

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Green tea (−)-epigallocatechin-gallate modulates early events in huntingtin misfolding and reduces toxicity in Huntington's disease models

Human molecular genetics, 2006-09, Vol.15 (18), p.2743-2751

2006

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Up-regulation of GLT1 expression increases glutamate uptake and attenuates the Huntington's disease phenotype in the R6/2 mouse

Neuroscience, 2008-04, Vol.153 (1), p.329-337

2008

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Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

Nature genetics, 2004-06, Vol.36 (6), p.585-595

2004

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Selective histone deacetylase (HDAC) inhibition imparts beneficial effects in Huntington's disease mice: implications for the ubiquitin―proteasomal and autophagy systems

Human molecular genetics, 2012-12, Vol.21 (24), p.5280-5293

2012

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Combined Treatment with the Mood Stabilizers Lithium and Valproate Produces Multiple Beneficial Effects in Transgenic Mouse Models of Huntington's Disease

Neuropsychopharmacology (New York, N.Y.), 2011-11, Vol.36 (12), p.2406-2421

2011

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The role of kynurenines in disorders of the central nervous system: Possibilities for neuroprotection

Journal of the neurological sciences, 2009-08, Vol.283 (1), p.21-27

2009

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Inhibition of specific HDACs and sirtuins suppresses pathogenesis in a Drosophila model of Huntington’s disease

Human molecular genetics, 2008-12, Vol.17 (23), p.3767-3775

2008

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Pharmacologic approaches to the treatment of Huntington's disease

Movement disorders, 2012-01, Vol.27 (1), p.31-41

2012

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Quercetin Improves Behavioral Deficiencies, Restores Astrocytes and Microglia, and Reduces Serotonin Metabolism in 3‐Nitropropionic Acid‐Induced Rat Model of Huntington's Disease

CNS neuroscience & therapeutics, 2014-01, Vol.20 (1), p.10-19

2014

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Treatment of depressive‐like behaviour in Huntington's disease mice by chronic sertraline and exercise

British journal of pharmacology, 2012-03, Vol.165 (5), p.1375-1389

2012

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Apoptosis and Caspases in Neurodegenerative Diseases

The New England journal of medicine, 2003-04, Vol.348 (14), p.1365-1375

Friedlander, Robert M

2003

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Resveratrol protects against peripheral deficits in a mouse model of Huntington's disease

Experimental neurology, 2010-09, Vol.225 (1), p.74-84

2010

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Seizures in juvenile Huntington's disease: Frequency and characterization in a multicenter cohort

Movement disorders, 2012-12, Vol.27 (14), p.1797-1800

2012

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Weight loss in Huntington disease increases with higher CAG repeat number

Neurology, 2008-11, Vol.71 (19), p.1506-1513

2008

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Rilmenidine attenuates toxicity of polyglutamine expansions in a mouse model of Huntington's disease

Human molecular genetics, 2010-06, Vol.19 (11), p.2144-2153

2010

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Multiple roles of HDAC inhibition in neurodegenerative conditions

Multi-target-Directed Ligands To Combat Neurodegenerative Diseases

RNAi: a potential new class of therapeutic for human genetic disease

Tetrabenazine for the Treatment of Hyperkinetic Movement Disorders: A Review of the Literature

The kynurenine pathway in neurodegenerative diseases: Mechanistic and therapeutic considerations

Combination therapy with Coenzyme Q₁₀ and creatine produces additive neuroprotective effects in models of Parkinson's and Huntington's Diseases

Pharmacologic activation of mitochondrial biogenesis exerts widespread beneficial effects in a transgenic mouse model of Huntington's disease

Evidence-based guideline: pharmacologic treatment of chorea in Huntington disease: report of the guideline development subcommittee of the American Academy of Neurology

Exendin-4 Improves Glycemic Control, Ameliorates Brain and Pancreatic Pathologies, and Extends Survival in a Mouse Model of Huntington's Disease

The endocannabinoid system as a target for the treatment of motor dysfunction

Green tea (−)-epigallocatechin-gallate modulates early events in huntingtin misfolding and reduces toxicity in Huntington's disease models

Up-regulation of GLT1 expression increases glutamate uptake and attenuates the Huntington's disease phenotype in the R6/2 mouse

Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

Selective histone deacetylase (HDAC) inhibition imparts beneficial effects in Huntington's disease mice: implications for the ubiquitin―proteasomal and autophagy systems

Combined Treatment with the Mood Stabilizers Lithium and Valproate Produces Multiple Beneficial Effects in Transgenic Mouse Models of Huntington's Disease

The role of kynurenines in disorders of the central nervous system: Possibilities for neuroprotection

Inhibition of specific HDACs and sirtuins suppresses pathogenesis in a Drosophila model of Huntington’s disease

Pharmacologic approaches to the treatment of Huntington's disease

Quercetin Improves Behavioral Deficiencies, Restores Astrocytes and Microglia, and Reduces Serotonin Metabolism in 3‐Nitropropionic Acid‐Induced Rat Model of Huntington's Disease

Treatment of depressive‐like behaviour in Huntington's disease mice by chronic sertraline and exercise

Apoptosis and Caspases in Neurodegenerative Diseases

Resveratrol protects against peripheral deficits in a mouse model of Huntington's disease

Seizures in juvenile Huntington's disease: Frequency and characterization in a multicenter cohort

Weight loss in Huntington disease increases with higher CAG repeat number

Rilmenidine attenuates toxicity of polyglutamine expansions in a mouse model of Huntington's disease

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