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The cardiotoxicity and myocyte damage caused by small molecule anticancer tyrosine kinase inhibitors is correlated with lack of target specificity

Toxicology and applied pharmacology, 2010-04, Vol.244 (2), p.190-195

Hasinoff, Brian B.

2010

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The lack of target specificity of small molecule anticancer kinase inhibitors is correlated with their ability to damage myocytes in vitro

Toxicology and applied pharmacology, 2010-12, Vol.249 (2), p.132-139

2010

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A diazirine-based photoaffinity etoposide probe for labeling topoisomerase II

Bioorganic & medicinal chemistry, 2010-01, Vol.18 (2), p.830-838

2010

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The dihydroorotase inhibitor 5-aminoorotic acid inhibits the metabolism in the rat of the cardioprotective drug dexrazoxane and its one-ring open metabolites

Drug metabolism and disposition, 2008-09, Vol.36 (9), p.1780-1785

2008

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Metabolism of the one-ring open metabolites of the cardioprotective drug dexrazoxane to its active metal-chelating form in the rat

Drug metabolism and disposition, 2005-09, Vol.33 (9), p.1367-1372

2005

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Expression of a stress‐induced hemoglobin affects NO levels produced by alfalfa root cultures under hypoxic stress

The Plant journal : for cell and molecular biology, 2003-09, Vol.35 (6), p.763-770

2003

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Class-1 hemoglobins, nitrate and NO levels in anoxic maize cell-suspension cultures

Planta, 2004-05, Vol.219 (1), p.66-72

2004

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Design, synthesis, and biological evaluation of a novel series of bisintercalating DNA-binding piperazine-linked bisanthrapyrazole compounds as anticancer agents

Bioorganic & medicinal chemistry, 2011-12, Vol.19 (23), p.7023-7032

2011

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Metabolism of the cardioprotective drug dexrazoxane and one of its metabolites by isolated rat myocytes, hepatocytes, and blood

Drug metabolism and disposition, 2005-06, Vol.33 (6), p.719

2005

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The Dual-Targeted HER1/HER2 Tyrosine Kinase Inhibitor Lapatinib Strongly Potentiates the Cardiac Myocyte-Damaging Effects of Doxorubicin

Cardiovascular toxicology, 2013-03, Vol.13 (1), p.33-47

2013

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Dihydroorotase catalyzes the ring opening of the hydrolysis intermediates of the cardioprotective drug dexrazoxane (ICRF-187)

Drug metabolism and disposition, 2002-12, Vol.30 (12), p.1431-1435

2002

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High-throughput fluorescence flow-injection topoisomerase II inhibition assay

Journal of chromatography. B, Biomedical sciences and applications, 2001-09, Vol.760 (2), p.263-269

2001

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Design, synthesis and biological evaluation of a novel series of anthrapyrazoles linked with netropsin-like oligopyrrole carboxamides as anticancer agents

Bioorganic & medicinal chemistry, 2010-06, Vol.18 (11), p.3974-3984

2010

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Chemical reactivity and microbicidal action of bethoxazin

Bioorganic & medicinal chemistry, 2012-02, Vol.20 (4), p.1494-1501

2012

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Role of NADPH cytochrome P450 reductase in activation of RH1

Cancer chemotherapy and pharmacology, 2007-10, Vol.60 (5), p.713-723

2007

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B16 melanoma cell arrest in the mouse liver induces nitric oxide release and sinusoidal cytotoxicity : A natural hepatic defense against metastasis

Cancer research (Chicago, Ill.), 2000-10, Vol.60 (20), p.5862-5869

2000

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The structure-based design, synthesis, and biological evaluation of DNA-binding amide linked bisintercalating bisanthrapyrazole anticancer compounds

Bioorganic & medicinal chemistry, 2009-07, Vol.17 (13), p.4575-4582

2009

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Arrest of B16 Melanoma Cells in the Mouse Pulmonary Microcirculation Induces Endothelial Nitric Oxide Synthase-Dependent Nitric Oxide Release that Is Cytotoxic to the Tumor Cells

The American journal of pathology, 2003-02, Vol.162 (2), p.403-412

2003

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Evaluation of relative DNA binding affinities of anthrapyrazoles by electrospray ionization mass spectrometry

Journal of mass spectrometry., 2007-05, Vol.42 (5), p.681-688

2007

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The structure-based design, synthesis and biological evaluation of DNA-binding bisintercalating bisanthrapyrazole anticancer compounds

Bioorganic & medicinal chemistry, 2008-04, Vol.16 (7), p.3959-3968

2008

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The doxorubicin-cardioprotective drug dexrazoxane undergoes metabolism in the rat to its metal ion-chelating form ADR-925

Cancer chemotherapy and pharmacology, 2002-12, Vol.50 (6), p.509-513

2002

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Structure-activity study of the interaction of bioreductive benzoquinone alkylating agents with DNA topoisomerase II

Cancer chemotherapy and pharmacology, 2006-02, Vol.57 (2), p.221-233

2006

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Metabolism of dexrazoxane (ICRF-187) used as a rescue agent in cancer patients treated with high-dose etoposide

Cancer chemotherapy and pharmacology, 2003-08, Vol.52 (2), p.167-174

2003

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Structure-activity studies with cytotoxic anthrapyrazoles

Oncology reports, 2006-06, Vol.15 (6), p.1575-1580

2006

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Pharmacodynamics of the Hydrolysis-Activation of the Cardioprotective Agent (+)-1,2-Bis(3,5-dioxopiperazinyl-1-yl)propane

Journal of pharmaceutical sciences, 1994-01, Vol.83 (1), p.64-67

Hasinoff, Brian B.

1994

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The cardiotoxicity and myocyte damage caused by small molecule anticancer tyrosine kinase inhibitors is correlated with lack of target specificity

The lack of target specificity of small molecule anticancer kinase inhibitors is correlated with their ability to damage myocytes in vitro

A diazirine-based photoaffinity etoposide probe for labeling topoisomerase II

The dihydroorotase inhibitor 5-aminoorotic acid inhibits the metabolism in the rat of the cardioprotective drug dexrazoxane and its one-ring open metabolites

Metabolism of the one-ring open metabolites of the cardioprotective drug dexrazoxane to its active metal-chelating form in the rat

Expression of a stress‐induced hemoglobin affects NO levels produced by alfalfa root cultures under hypoxic stress

Class-1 hemoglobins, nitrate and NO levels in anoxic maize cell-suspension cultures

Design, synthesis, and biological evaluation of a novel series of bisintercalating DNA-binding piperazine-linked bisanthrapyrazole compounds as anticancer agents

Metabolism of the cardioprotective drug dexrazoxane and one of its metabolites by isolated rat myocytes, hepatocytes, and blood

The Dual-Targeted HER1/HER2 Tyrosine Kinase Inhibitor Lapatinib Strongly Potentiates the Cardiac Myocyte-Damaging Effects of Doxorubicin

Dihydroorotase catalyzes the ring opening of the hydrolysis intermediates of the cardioprotective drug dexrazoxane (ICRF-187)

High-throughput fluorescence flow-injection topoisomerase II inhibition assay

Design, synthesis and biological evaluation of a novel series of anthrapyrazoles linked with netropsin-like oligopyrrole carboxamides as anticancer agents

Chemical reactivity and microbicidal action of bethoxazin

Role of NADPH cytochrome P450 reductase in activation of RH1

B16 melanoma cell arrest in the mouse liver induces nitric oxide release and sinusoidal cytotoxicity : A natural hepatic defense against metastasis

The structure-based design, synthesis, and biological evaluation of DNA-binding amide linked bisintercalating bisanthrapyrazole anticancer compounds

Arrest of B16 Melanoma Cells in the Mouse Pulmonary Microcirculation Induces Endothelial Nitric Oxide Synthase-Dependent Nitric Oxide Release that Is Cytotoxic to the Tumor Cells

Evaluation of relative DNA binding affinities of anthrapyrazoles by electrospray ionization mass spectrometry

The structure-based design, synthesis and biological evaluation of DNA-binding bisintercalating bisanthrapyrazole anticancer compounds

The doxorubicin-cardioprotective drug dexrazoxane undergoes metabolism in the rat to its metal ion-chelating form ADR-925

Structure-activity study of the interaction of bioreductive benzoquinone alkylating agents with DNA topoisomerase II

Metabolism of dexrazoxane (ICRF-187) used as a rescue agent in cancer patients treated with high-dose etoposide

Structure-activity studies with cytotoxic anthrapyrazoles

Pharmacodynamics of the Hydrolysis-Activation of the Cardioprotective Agent (+)-1,2-Bis(3,5-dioxopiperazinyl-1-yl)propane

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