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Omega-3 Fatty Acids Activate Ciliary FFAR4 to Control Adipogenesis

Cell, 2019-11, Vol.179 (6), p.1289-1305.e21

2019

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Discovery of a Class of Endogenous Mammalian Lipids with Anti-Diabetic and Anti-inflammatory Effects

Cell, 2014-10, Vol.159 (2), p.318-332

2014

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Vaccarin improves insulin sensitivity and glucose uptake in diet-induced obese mice via activation of GPR120-PI3K/AKT/GLUT4 pathway

Biochemical and biophysical research communications, 2022-12, Vol.634, p.189-195

2022

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Positive interplay between FFAR4/GPR120, DPP-IV inhibition and GLP-1 in beta cell proliferation and glucose homeostasis in obese high fat fed mice

Peptides (New York, N.Y. : 1980), 2024-07, Vol.177, p.171218, Article 171218

2024

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Nutritional Signaling via Free Fatty Acid Receptors

International Journal of Molecular Sciences, 2016-03, Vol.17 (4), p.450-450

2016

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Preference for dietary fat: From detection to disease

Progress in lipid research, 2020-04, Vol.78, p.101032-101032, Article 101032

2020

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Flaxseed oil rich in omega-3 protects aorta against inflammation and endoplasmic reticulum stress partially mediated by GPR120 receptor in obese, diabetic and dyslipidemic mice models

The Journal of nutritional biochemistry, 2018-03, Vol.53, p.9-19

2018

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Unsaturated fatty acids from flaxseed oil and exercise modulate GPR120 but not GPR40 in the liver of obese mice: a new anti-inflammatory approach

The Journal of nutritional biochemistry, 2019-04, Vol.66, p.52-62

2019

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Dipeptidyl peptidase-4 and GLP-1 interplay in STC-1 and GLUTag cell lines

Peptides (New York, N.Y. : 1980), 2020-12, Vol.134, p.170419-170419, Article 170419

2020

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Linoleic acid promotes testosterone production by activating Leydig cell GPR120/ ERK pathway and restores BPA-impaired testicular toxicity

Steroids, 2020-11, Vol.163, p.108677-108677, Article 108677

2020

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FFA4 (GPR120) as a fatty acid sensor involved in appetite control, insulin sensitivity and inflammation regulation

Molecular aspects of medicine, 2018-12, Vol.64, p.92-108

Im, Dong-Soon

2018

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Enzymatically-epoxidized docosahexaenoic acid, 19,20-EpDPE, suppresses hepatic crown-like structure formation and nonalcoholic steatohepatitis fibrosis through GPR120

Biochimica et biophysica acta. Molecular and cell biology of lipids, 2023-03, Vol.1868 (3), p.159275-159275, Article 159275

2023

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Fat taste signal transduction and its possible negative modulator components

Progress in lipid research, 2020-07, Vol.79, p.101035-101035, Article 101035

2020

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Adaptive thermogenesis by dietary n-3 polyunsaturated fatty acids: Emerging evidence and mechanisms

Biochimica et biophysica acta. Molecular and cell biology of lipids, 2019-01, Vol.1864 (1), p.59-70

2019

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GPR120 facilitates cholesterol efflux in macrophages through activation of AMPK signaling pathway

The FEBS journal, 2020-12, Vol.287 (23), p.5080-5095

2020

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Free fatty acids-sensing G protein-coupled receptors in drug targeting and therapeutics

Current medicinal chemistry, 2013-10, Vol.20 (31), p.3855-3871

2013

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Omega-3 fatty acids in anti-inflammation (pro-resolution) and GPCRs

Progress in lipid research, 2012-07, Vol.51 (3), p.232-237

Im, Dong-Soon

2012

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Pinocembrin and its linolenoyl ester derivative induce wound healing activity in HaCaT cell line potentially involving a GPR120/FFA4 mediated pathway

Bioorganic chemistry, 2021-03, Vol.108, p.104657, Article 104657

2021

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9-PAHSA promotes browning of white fat via activating G-protein-coupled receptor 120 and inhibiting lipopolysaccharide / NF-kappa B pathway

Biochemical and biophysical research communications, 2018-11, Vol.506 (1), p.153-160

2018

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DHA-Provoked Reduction in Adipogenesis and Glucose Uptake Could Be Mediated by Gps2 Upregulation in Immature 3T3-L1 Cells

International journal of molecular sciences, 2023-09, Vol.24 (17), p.13325

2023

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Identification of G-protein-coupled receptor 120 as a tumor-promoting receptor that induces angiogenesis and migration in human colorectal carcinoma

Oncogene, 2013-12, Vol.32 (49), p.5541-5550

2013

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The regulation of adipogenesis through GPR120

Biochemical and biophysical research communications, 2007-03, Vol.354 (2), p.591-597

2007

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GPR120 Inhibits RANKL-Induced Osteoclast Formation and Resorption by Attenuating Reactive Oxygen Species Production in RAW264.7 Murine Macrophages

International journal of molecular sciences, 2021-10, Vol.22 (19), p.10544

2021

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Omega-3 polyunsaturated fatty acids ameliorate ethanol-induced adipose hyperlipolysis: A mechanism for hepatoprotective effect against alcoholic liver disease

Biochimica et biophysica acta. Molecular basis of disease, 2017-12, Vol.1863 (12), p.3190-3201

2017

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Lipid-Sensing Receptor FFAR4 Modulates Pulmonary Epithelial Homeostasis following Immunogenic Exposures Independently of the FFAR4 Ligand Docosahexaenoic Acid (DHA)

International journal of molecular sciences, 2023-04, Vol.24 (8), p.7072

2023

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Omega-3 Fatty Acids Activate Ciliary FFAR4 to Control Adipogenesis

Discovery of a Class of Endogenous Mammalian Lipids with Anti-Diabetic and Anti-inflammatory Effects

Vaccarin improves insulin sensitivity and glucose uptake in diet-induced obese mice via activation of GPR120-PI3K/AKT/GLUT4 pathway

Positive interplay between FFAR4/GPR120, DPP-IV inhibition and GLP-1 in beta cell proliferation and glucose homeostasis in obese high fat fed mice

Nutritional Signaling via Free Fatty Acid Receptors

Preference for dietary fat: From detection to disease

Flaxseed oil rich in omega-3 protects aorta against inflammation and endoplasmic reticulum stress partially mediated by GPR120 receptor in obese, diabetic and dyslipidemic mice models

Unsaturated fatty acids from flaxseed oil and exercise modulate GPR120 but not GPR40 in the liver of obese mice: a new anti-inflammatory approach

Dipeptidyl peptidase-4 and GLP-1 interplay in STC-1 and GLUTag cell lines

Linoleic acid promotes testosterone production by activating Leydig cell GPR120/ ERK pathway and restores BPA-impaired testicular toxicity

FFA4 (GPR120) as a fatty acid sensor involved in appetite control, insulin sensitivity and inflammation regulation

Enzymatically-epoxidized docosahexaenoic acid, 19,20-EpDPE, suppresses hepatic crown-like structure formation and nonalcoholic steatohepatitis fibrosis through GPR120

Fat taste signal transduction and its possible negative modulator components

Adaptive thermogenesis by dietary n-3 polyunsaturated fatty acids: Emerging evidence and mechanisms

GPR120 facilitates cholesterol efflux in macrophages through activation of AMPK signaling pathway

Free fatty acids-sensing G protein-coupled receptors in drug targeting and therapeutics

Omega-3 fatty acids in anti-inflammation (pro-resolution) and GPCRs

Pinocembrin and its linolenoyl ester derivative induce wound healing activity in HaCaT cell line potentially involving a GPR120/FFA4 mediated pathway

9-PAHSA promotes browning of white fat via activating G-protein-coupled receptor 120 and inhibiting lipopolysaccharide / NF-kappa B pathway

DHA-Provoked Reduction in Adipogenesis and Glucose Uptake Could Be Mediated by Gps2 Upregulation in Immature 3T3-L1 Cells

Identification of G-protein-coupled receptor 120 as a tumor-promoting receptor that induces angiogenesis and migration in human colorectal carcinoma

The regulation of adipogenesis through GPR120

GPR120 Inhibits RANKL-Induced Osteoclast Formation and Resorption by Attenuating Reactive Oxygen Species Production in RAW264.7 Murine Macrophages

Omega-3 polyunsaturated fatty acids ameliorate ethanol-induced adipose hyperlipolysis: A mechanism for hepatoprotective effect against alcoholic liver disease

Lipid-Sensing Receptor FFAR4 Modulates Pulmonary Epithelial Homeostasis following Immunogenic Exposures Independently of the FFAR4 Ligand Docosahexaenoic Acid (DHA)

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