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Apelin pathway in cardiovascular, kidney, and metabolic diseases: Therapeutic role of apelin analogs and apelin receptor agonists

Peptides (New York, N.Y. : 1980), 2022-01, Vol.147, p.170697-170697, Article 170697

2022

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Apelin/APJ system: an emerging therapeutic target for respiratory diseases

Cellular and molecular life sciences : CMLS, 2020-08, Vol.77 (15), p.2919-2930

2020

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Structural Basis for Apelin Control of the Human Apelin Receptor

Structure (London), 2017-06, Vol.25 (6), p.858-866.e4

2017

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The regulatory role of the apelin/APJ axis in scarring: Identification of upstream and downstream mechanisms

Biochimica et biophysica acta. Molecular basis of disease, 2024-04, Vol.1870 (4), p.167125-167125, Article 167125

2024

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Apelin-36-[L28A] and Apelin-36-[L28C(30kDa-PEG)] peptides that improve diet induced obesity are G protein biased ligands at the apelin receptor

Peptides (New York, N.Y. : 1980), 2019-11, Vol.121, p.170139-170139, Article 170139

2019

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Elabela and Apelin actions in healthy and pathological pregnancies

Cytokine & growth factor reviews, 2019-04, Vol.46, p.45-53

2019

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Targeting the apelin pathway as a novel therapeutic approach for cardiovascular diseases

Biochimica et biophysica acta. Molecular basis of disease, 2017-08, Vol.1863 (8), p.1942-1950

2017

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Flutamide Alters the Expression of Chemerin, Apelin, and Vaspin and Their Respective Receptors in the Testes of Adult Rats

International journal of molecular sciences, 2020-06, Vol.21 (12), p.4439

2020

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Molecular determinants on extracellular loop domains that dictate interaction between β‐arrestin and human APJ receptor

FEBS letters, 2019-03, Vol.593 (6), p.634-643

2019

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Postnatal developmental expression and localization of apelin and apelin receptor protein in the ovary and uterus of mice

Molecular reproduction and development, 2023-01, Vol.90 (1), p.42-52

2023

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Elabela‐apelin‐12, 17, 36/APJ system promotes platelet aggregation and thrombosis via activating the PANX1‐P2X7 signaling pathway

Journal of cellular biochemistry, 2023-04, Vol.124 (4), p.586-605

2023

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Expression and localization of apelin and its receptor in the testes of diabetic mice and its possible role in steroidogenesis

Cytokine (Philadelphia, Pa.), 2021-08, Vol.144, p.155554-155554, Article 155554

2021

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Identification of potent pyrazole based APELIN receptor (APJ) agonists

Bioorganic & medicinal chemistry, 2020-02, Vol.28 (4), p.115237-115237, Article 115237

2020

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Apelin binding to human APJ receptor leads to biased signaling

Biochimica et biophysica acta, 2016-12, Vol.1864 (12), p.1748-1756

2016

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Bioactivity of the putative apelin proprotein expands the repertoire of apelin receptor ligands

Biochimica et biophysica acta, 2017-08, Vol.1861 (8), p.1901-1912

2017

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Localized apelin-17 analogue-bicelle interactions as a facilitator of membrane-catalyzed receptor recognition and binding

Biochimica et biophysica acta. Biomembranes, 2024-03, Vol.1866 (3), p.184289-184289, Article 184289

2024

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Apelin C-Terminal Fragments: Biological Properties and Therapeutic Potential

Biochemistry (Moscow), 2023-11, Vol.88 (11), p.1874-1889

2023

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Comparative Study of Elabela and Apelin on Apelin Receptor Activation Through β-Arrestin Recruitment

Molecular biotechnology, 2023-03, Vol.65 (3), p.394-400

2023

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Apelin receptor modulation mitigates letrozole-induced polycystic ovarian pathogenesis in mice

Cytokine (Philadelphia, Pa.), 2024-07, Vol.179, p.156639-156639, Article 156639

2024

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Structure, amphipathy, and topology of the membrane-proximal helix 8 influence apelin receptor plasma membrane localization

Biochimica et biophysica acta. Biomembranes, 2019-11, Vol.1861 (11), p.183036-183036, Article 183036

2019

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Apelin Enhances Brown Adipogenesis and Browning of White Adipocytes

The Journal of biological chemistry, 2015-06, Vol.290 (23), p.14679-14691

2015

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MicroRNA-631 Resensitizes Doxorubicin-Resistant Chondrosarcoma Cells by Targeting Apelin

International journal of molecular sciences, 2023-01, Vol.24 (1), p.839

2023

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Apelin-13 Protects Dopaminergic Neurons against Rotenone-Induced Neurotoxicity through the AMPK/mTOR/ULK-1 Mediated Autophagy Activation

International journal of molecular sciences, 2020-11, Vol.21 (21), p.8376

2020

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Elevated reactivity of Apelin inhibited renal fibrosis induced by chronic intermittent hypoxia

Archives of biochemistry and biophysics, 2021-10, Vol.711, p.109021-109021, Article 109021

2021

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Multiple roles of apelin/APJ system in eye diseases

Peptides (New York, N.Y. : 1980), 2022-06, Vol.152, p.170767-170767, Article 170767

2022

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Apelin pathway in cardiovascular, kidney, and metabolic diseases: Therapeutic role of apelin analogs and apelin receptor agonists

Apelin/APJ system: an emerging therapeutic target for respiratory diseases

Structural Basis for Apelin Control of the Human Apelin Receptor

The regulatory role of the apelin/APJ axis in scarring: Identification of upstream and downstream mechanisms

Apelin-36-[L28A] and Apelin-36-[L28C(30kDa-PEG)] peptides that improve diet induced obesity are G protein biased ligands at the apelin receptor

Elabela and Apelin actions in healthy and pathological pregnancies

Targeting the apelin pathway as a novel therapeutic approach for cardiovascular diseases

Flutamide Alters the Expression of Chemerin, Apelin, and Vaspin and Their Respective Receptors in the Testes of Adult Rats

Molecular determinants on extracellular loop domains that dictate interaction between β‐arrestin and human APJ receptor

Postnatal developmental expression and localization of apelin and apelin receptor protein in the ovary and uterus of mice

Elabela‐apelin‐12, 17, 36/APJ system promotes platelet aggregation and thrombosis via activating the PANX1‐P2X7 signaling pathway

Expression and localization of apelin and its receptor in the testes of diabetic mice and its possible role in steroidogenesis

Identification of potent pyrazole based APELIN receptor (APJ) agonists

Apelin binding to human APJ receptor leads to biased signaling

Bioactivity of the putative apelin proprotein expands the repertoire of apelin receptor ligands

Localized apelin-17 analogue-bicelle interactions as a facilitator of membrane-catalyzed receptor recognition and binding

Apelin C-Terminal Fragments: Biological Properties and Therapeutic Potential

Comparative Study of Elabela and Apelin on Apelin Receptor Activation Through β-Arrestin Recruitment

Apelin receptor modulation mitigates letrozole-induced polycystic ovarian pathogenesis in mice

Structure, amphipathy, and topology of the membrane-proximal helix 8 influence apelin receptor plasma membrane localization

Apelin Enhances Brown Adipogenesis and Browning of White Adipocytes

MicroRNA-631 Resensitizes Doxorubicin-Resistant Chondrosarcoma Cells by Targeting Apelin

Apelin-13 Protects Dopaminergic Neurons against Rotenone-Induced Neurotoxicity through the AMPK/mTOR/ULK-1 Mediated Autophagy Activation

Elevated reactivity of Apelin inhibited renal fibrosis induced by chronic intermittent hypoxia

Multiple roles of apelin/APJ system in eye diseases

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