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Structure-based drug design: aiming for a perfect fit

Essays in biochemistry, 2017-11, Vol.61 (5), p.431

2017

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Benzimidazole inhibitors of the protein kinase CHK2: Clarification of the binding mode by flexible side chain docking and protein–ligand crystallography

Bioorganic & medicinal chemistry, 2012-11, Vol.20 (22), p.6630-6639

2012

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Molecular recognition of ternary complexes: a new dimension in the structure-guided design of chemical degraders

Essays in biochemistry, 2017-11, Vol.61 (5), p.505

2017

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Current perspectives in fragment-based lead discovery (FBLD)

Essays in biochemistry, 2017-11, Vol.61 (5), p.453

2017

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Identification of autophosphorylation inhibitors of the inositol-requiring enzyme 1 alpha (IRE1α) by high-throughput screening using a DELFIA assay

Journal of biomolecular screening, 2013-03, Vol.18 (3), p.298-308

2013

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Fragment-based drug discovery and its application to challenging drug targets

Essays in biochemistry, 2017-11, Vol.61 (5), p.475

2017

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Structure-based discovery of cyclin-dependent protein kinase inhibitors

Essays in biochemistry, 2017-11, Vol.61 (5), p.439

2017

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The potential of cryo-electron microscopy for structure-based drug design

Essays in biochemistry, 2017-11, Vol.61 (5), p.543

2017

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Protein degradation: a validated therapeutic strategy with exciting prospects

Essays in biochemistry, 2017-11, Vol.61 (5), p.517

2017

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Structural and functional characterisation of human RNA helicase DHX8 provides insights into the mechanism of RNA-stimulated ADP release

Biochemical journal, 2019-09, Vol.476 (18), p.2521-2543

2019

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X-ray free electron laser: opportunities for drug discovery

Essays in biochemistry, 2017-11, Vol.61 (5), p.529

2017

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Synthesis and profiling of a 3-aminopyridin-2-one-based kinase targeted fragment library: Identification of 3-amino-5-(pyridin-4-yl)pyridin-2(1H)-one scaffold for monopolar spindle 1 (MPS1) and Aurora kinases inhibition

Bioorganic & medicinal chemistry, 2018-07, Vol.26 (11), p.3021-3029

2018

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Mass spectrometry for fragment screening

Essays in biochemistry, 2017-11, Vol.61 (5), p.465

2017

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The SGC beyond structural genomics: redefining the role of 3D structures by coupling genomic stratification with fragment-based discovery

Essays in biochemistry, 2017-11, Vol.61 (5), p.495

2017

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Crystal structure and assembly of a eukaryotic small heat shock protein

Nature structural & molecular biology, 2001-12, Vol.8 (12), p.1025-1030

2001

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Structure of the Epigenetic Oncogene MMSET and Inhibition by N‑Alkyl Sinefungin Derivatives

ACS chemical biology, 2016-11, Vol.11 (11), p.3093-3105

2016

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Evaluation of APOBEC3B Recognition Motifs by NMR Reveals Preferred Substrates

ACS chemical biology, 2018-09, Vol.13 (9), p.2427-2432

2018

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NMR in structure-based drug design

Essays in biochemistry, 2017-11, Vol.61 (5), p.485

2017

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Analysis of water patterns in protein kinase binding sites

Proteins, structure, function, and bioinformatics, 2011-07, Vol.79 (7), p.2109-2121

2011

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Insights into the Conformational Variability and Regulation of Human Nek2 Kinase

Journal of molecular biology, 2009-02, Vol.386 (2), p.476-485

2009

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PI(3) kinases: revealing the delta lady

Nature chemical biology, 2010-02, Vol.6 (2), p.82

2010

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Crystal structure of truncated human βB1‐crystallin

Protein science, 2003-11, Vol.12 (11), p.2606-2612

2003

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Crystallization of Enzyme IIB of the Cellobiose-specific Phosphotransferase System of Escherichia coli

Journal of molecular biology, 1994-06, Vol.239 (4), p.588-590

1994

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Structure-based drug design: aiming for a perfect fit

Benzimidazole inhibitors of the protein kinase CHK2: Clarification of the binding mode by flexible side chain docking and protein–ligand crystallography

Molecular recognition of ternary complexes: a new dimension in the structure-guided design of chemical degraders

Current perspectives in fragment-based lead discovery (FBLD)

Identification of autophosphorylation inhibitors of the inositol-requiring enzyme 1 alpha (IRE1α) by high-throughput screening using a DELFIA assay

Fragment-based drug discovery and its application to challenging drug targets

Structure-based discovery of cyclin-dependent protein kinase inhibitors

The potential of cryo-electron microscopy for structure-based drug design

Protein degradation: a validated therapeutic strategy with exciting prospects

Structural and functional characterisation of human RNA helicase DHX8 provides insights into the mechanism of RNA-stimulated ADP release

X-ray free electron laser: opportunities for drug discovery

Synthesis and profiling of a 3-aminopyridin-2-one-based kinase targeted fragment library: Identification of 3-amino-5-(pyridin-4-yl)pyridin-2(1H)-one scaffold for monopolar spindle 1 (MPS1) and Aurora kinases inhibition

Mass spectrometry for fragment screening

The SGC beyond structural genomics: redefining the role of 3D structures by coupling genomic stratification with fragment-based discovery

Crystal structure and assembly of a eukaryotic small heat shock protein

Structure of the Epigenetic Oncogene MMSET and Inhibition by N‑Alkyl Sinefungin Derivatives

Evaluation of APOBEC3B Recognition Motifs by NMR Reveals Preferred Substrates

NMR in structure-based drug design

Analysis of water patterns in protein kinase binding sites

Insights into the Conformational Variability and Regulation of Human Nek2 Kinase

PI(3) kinases: revealing the delta lady

Crystal structure of truncated human βB1‐crystallin

Crystallization of Enzyme IIB of the Cellobiose-specific Phosphotransferase System of Escherichia coli

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