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Discovery and design of molecular glue enhancers of CDK12-DDB1 interactions for targeted degradation of cyclin K

RSC chemical biology, 2024-10

2024

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Chemical Proteomics with Novel Fully Functionalized Fragments and Stringent Target Prioritization Identifies the Glutathione-Dependent Isomerase GSTZ1 as a Lung Cancer Target

ACS chemical biology, 2023-02, Vol.18 (2), p.251-264

2023

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Inhibition of p53 DNA binding by a small molecule protects mice from radiation toxicity

Oncogene, 2020-07, Vol.39 (29), p.5187-5200

2020

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MDMX inhibits casein kinase 1α activity and stimulates Wnt signaling

The EMBO journal, 2020-07, Vol.39 (14), p.e104410-n/a

2020

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NMR Analyses of Acetylated H2A.Z Isoforms Identify Differential Binding Interactions with the Bromodomain of the NURF Nucleosome Remodeling Complex

Biochemistry (Easton), 2020-05, Vol.59 (20), p.1871-1880

2020

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Tumor-derived CK1α mutations enhance MDMX inhibition of p53

Oncogene, 2020-01, Vol.39 (1), p.176-186

2020

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Ligand-mediated protein degradation reveals functional conservation among sequence variants of the CUL4-type E3 ligase substrate receptor cereblon

The Journal of biological chemistry, 2018-04, Vol.293 (16), p.6187-6200

2018

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Structural Basis of ALDH1A2 Inhibition by Irreversible and Reversible Small Molecule Inhibitors

ACS chemical biology, 2018-03, Vol.13 (3), p.582-590

2018

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Advances of small molecule targeting of kinases

Current opinion in chemical biology, 2017-08, Vol.39, p.126-132

2017

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Dual Targeting of WEE1 and PLK1 by AZD1775 Elicits Single Agent Cellular Anticancer Activity

ACS chemical biology, 2017-07, Vol.12 (7), p.1883-1892

2017

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Acetyl-lysine Binding Site of Bromodomain-Containing Protein 4 (BRD4) Interacts with Diverse Kinase Inhibitors

ACS chemical biology, 2014-05, Vol.9 (5), p.1160-1171

2014

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Cyclin-Dependent Kinase Inhibitor Dinaciclib Interacts with the Acetyl-Lysine Recognition Site of Bromodomains

ACS chemical biology, 2013-11, Vol.8 (11), p.2360-2365

2013

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MurA as a Primary Target of Tulipalin B and 6-Tuliposide B

Bioscience, biotechnology, and biochemistry, 2013, Vol.77 (12), p.2517-2519

2013

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Casein Kinase 1α Regulates an MDMX Intramolecular Interaction To Stimulate p53 Binding

Molecular and Cellular Biology, 2012-12, Vol.32 (23), p.4821-4832

2012

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A Novel Approach to the Discovery of Small-Molecule Ligands of CDK2

Chembiochem : a European journal of chemical biology, 2012-09, Vol.13 (14), p.2128-2136

2012

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Pyridylthiazole-based ureas as inhibitors of Rho associated protein kinases (ROCK1 and 2)

MedChemComm, 2012-06, Vol.3 (6), p.699-709

2012

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A Novel Mechanism by Which Small Molecule Inhibitors Induce the DFG Flip in Aurora A

ACS chemical biology, 2012-04, Vol.7 (4), p.698-706

2012

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Functional Consequence of Covalent Reaction of Phosphoenolpyruvate with UDP-N-acetylglucosamine 1-Carboxyvinyltransferase (MurA)

The Journal of biological chemistry, 2012-04, Vol.287 (16), p.12657-12667

2012

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Discovery of Marinopyrrole A (Maritoclax) as a Selective Mcl-1 Antagonist that Overcomes ABT-737 Resistance by Binding to and Targeting Mcl-1 for Proteasomal Degradation

The Journal of biological chemistry, 2012-03, Vol.287 (13), p.10224-10235

2012

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Molecular basis of glyphosate resistance - different approaches through protein engineering

The FEBS journal, 2011-08, Vol.278 (16), p.2753-2766

2011

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Discovery of a Potential Allosteric Ligand Binding Site in CDK2

ACS chemical biology, 2011-05, Vol.6 (5), p.492-501

2011

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The Akt activation inhibitor TCN-P inhibits Akt phosphorylation by binding to the PH domain of Akt and blocking its recruitment to the plasma membrane

Cell death and differentiation, 2010-11, Vol.17 (11), p.1795-1804

2010

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The Fungal Product Terreic Acid Is a Covalent Inhibitor of the Bacterial Cell Wall Biosynthetic Enzyme UDP-N-Acetylglucosamine 1-Carboxyvinyltransferase (MurA)

Biochemistry (Easton), 2010-05, Vol.49 (19), p.4276-4282

2010

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Structure-based Design of High Affinity Peptides Inhibiting the Interaction of p53 with MDM2 and MDMX

The Journal of biological chemistry, 2010-01, Vol.285 (3), p.2174-2183

2010

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Structural Characterization of the Hemophore HasAp from Pseudomonas aeruginosa: NMR Spectroscopy Reveals Protein−Protein Interactions between Holo-HasAp and Hemoglobin

Biochemistry (Easton), 2009-01, Vol.48 (1), p.96-109

2009

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Discovery and design of molecular glue enhancers of CDK12-DDB1 interactions for targeted degradation of cyclin K

Chemical Proteomics with Novel Fully Functionalized Fragments and Stringent Target Prioritization Identifies the Glutathione-Dependent Isomerase GSTZ1 as a Lung Cancer Target

Inhibition of p53 DNA binding by a small molecule protects mice from radiation toxicity

MDMX inhibits casein kinase 1α activity and stimulates Wnt signaling

NMR Analyses of Acetylated H2A.Z Isoforms Identify Differential Binding Interactions with the Bromodomain of the NURF Nucleosome Remodeling Complex

Tumor-derived CK1α mutations enhance MDMX inhibition of p53

Ligand-mediated protein degradation reveals functional conservation among sequence variants of the CUL4-type E3 ligase substrate receptor cereblon

Structural Basis of ALDH1A2 Inhibition by Irreversible and Reversible Small Molecule Inhibitors

Advances of small molecule targeting of kinases

Dual Targeting of WEE1 and PLK1 by AZD1775 Elicits Single Agent Cellular Anticancer Activity

Acetyl-lysine Binding Site of Bromodomain-Containing Protein 4 (BRD4) Interacts with Diverse Kinase Inhibitors

Cyclin-Dependent Kinase Inhibitor Dinaciclib Interacts with the Acetyl-Lysine Recognition Site of Bromodomains

MurA as a Primary Target of Tulipalin B and 6-Tuliposide B

Casein Kinase 1α Regulates an MDMX Intramolecular Interaction To Stimulate p53 Binding

A Novel Approach to the Discovery of Small-Molecule Ligands of CDK2

Pyridylthiazole-based ureas as inhibitors of Rho associated protein kinases (ROCK1 and 2)

A Novel Mechanism by Which Small Molecule Inhibitors Induce the DFG Flip in Aurora A

Functional Consequence of Covalent Reaction of Phosphoenolpyruvate with UDP-N-acetylglucosamine 1-Carboxyvinyltransferase (MurA)

Discovery of Marinopyrrole A (Maritoclax) as a Selective Mcl-1 Antagonist that Overcomes ABT-737 Resistance by Binding to and Targeting Mcl-1 for Proteasomal Degradation

Molecular basis of glyphosate resistance - different approaches through protein engineering

Discovery of a Potential Allosteric Ligand Binding Site in CDK2

The Akt activation inhibitor TCN-P inhibits Akt phosphorylation by binding to the PH domain of Akt and blocking its recruitment to the plasma membrane

The Fungal Product Terreic Acid Is a Covalent Inhibitor of the Bacterial Cell Wall Biosynthetic Enzyme UDP-N-Acetylglucosamine 1-Carboxyvinyltransferase (MurA)

Structure-based Design of High Affinity Peptides Inhibiting the Interaction of p53 with MDM2 and MDMX

Structural Characterization of the Hemophore HasAp from Pseudomonas aeruginosa: NMR Spectroscopy Reveals Protein−Protein Interactions between Holo-HasAp and Hemoglobin

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