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Advances and Challenges of HDAC Inhibitors in Cancer Therapeutics

Advances in cancer research, 2018, Vol.138, p.183-211

2018

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Design, synthesis and anti-tumor activity study of novel histone deacetylase inhibitors containing isatin-based caps and o-phenylenediamine-based zinc binding groups

Bioorganic & medicinal chemistry, 2017-06, Vol.25 (12), p.2981-2994

2017

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Discovery of a Novel Ubenimex Derivative as a First-in-Class Dual CD13/Proteasome Inhibitor for the Treatment of Cancer

Molecules (Basel, Switzerland), 2023-08, Vol.28 (17), p.6343

2023

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Diversifying the anthracycline class of anti-cancer drugs identifies aclarubicin for superior survival of acute myeloid leukemia patients

Molecular cancer, 2024-06, Vol.23 (1), p.120-16

2024

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A convenient guideline to determine if two Y-STR profiles are from the same lineage

Electrophoresis, 2016-07, Vol.37 (12), p.1659-1668

2016

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Design, synthesis and biological evaluation of dual-function inhibitors targeting NMDAR and HDAC for Alzheimer’s disease

Bioorganic chemistry, 2020-10, Vol.103, p.104109, Article 104109

2020

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CDK7-dependent transcriptional addiction in bone and soft tissue sarcomas: Present and Future

Biochimica et biophysica acta. Reviews on cancer, 2022-03, Vol.1877 (2), p.188680-188680, Article 188680

2022

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EVA/KH560 synergistically modified recycled concrete mechanical properties - Experiment and molecular dynamics simulations

Journal of molecular graphics & modelling, 2024-01, Vol.126, p.108641-108641, Article 108641

2024

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Nanomaterial-encapsulated dsRNA of ecdysone-induced early gene E75, a potential RNAi-based SIT strategy for pest control against Bactrocera dorsalis

International journal of biological macromolecules, 2024-04, Vol.263 (Pt 1), p.130607-130607, Article 130607

2024

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WebCSEA: web-based cell-type-specific enrichment analysis of genes

Nucleic acids research, 2022-07, Vol.50 (W1), p.W782-W790

2022

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Mesenchymal stem cell-derived extracellular vesicles accelerate diabetic wound healing by inhibiting NET-induced ferroptosis of endothelial cells

International journal of biological sciences, 2024-01, Vol.20 (9), p.3515-3529

2024

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Discovery of novel biphenyl-sulfonamide analogues as NLRP3 inflammasome inhibitors

Bioorganic chemistry, 2024-05, Vol.146, p.107263-107263, Article 107263

2024

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Environmental enrichment or selective activation of parvalbumin-expressing interneurons ameliorates synaptic and behavioral deficits in animal models with schizophrenia-like behaviors during adolescence

Molecular psychiatry, 2021-06, Vol.26 (6), p.2533-2552

2021

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Concentration-dependent Effects of Nuclear Lamins on Nuclear Size in Xenopus and Mammalian Cells

The Journal of biological chemistry, 2015-11, Vol.290 (46), p.27557-27571

2015

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Discovery of polymethoxyphenyl-pyridines bearing amino side chains as tubulin colchicine-binding site inhibitors

Bioorganic & medicinal chemistry, 2022-11, Vol.73, p.117007-117007, Article 117007

2022

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1,2-Isoselenazol-3(2H)-one derivatives as NDM-1 inhibitors displaying synergistic antimicrobial effects with meropenem on NDM-1 producing clinical isolates

Bioorganic chemistry, 2022-12, Vol.129, p.106153-106153, Article 106153

2022

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Unbalanced ER‐mitochondrial calcium homeostasis promotes mitochondrial dysfunction and associated apoptotic pathways activation in methylmercury exposed rat cortical neurons

Journal of biochemical and molecular toxicology, 2022-09, Vol.36 (9), p.e23136-n/a

2022

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Tacrine-hydroxamate derivatives as multitarget-directed ligands for the treatment of Alzheimer’s disease: Design, synthesis, and biological evaluation

Bioorganic chemistry, 2020-05, Vol.98, p.103721, Article 103721

2020

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Development of N-hydroxybenzamide derivatives with indole-containing cap group as histone deacetylases inhibitors

Bioorganic & medicinal chemistry, 2015-10, Vol.23 (19), p.6258-6270

2015

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Design, synthesis, and preliminary bioactivity evaluation of N 1 -hydroxyterephthalamide derivatives with indole cap as novel histone deacetylase inhibitors

Chemical biology & drug design, 2017-01, Vol.89 (1), p.38-46

2017

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Design, synthesis and preliminary evaluation of α-sulfonyl γ-(glycinyl-amino)proline peptidomimetics as matrix metalloproteinase inhibitors

Bioorganic & medicinal chemistry, 2014-06, Vol.22 (11), p.3055-3064

2014

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Discovery of a novel chimeric ubenimex-gemcitabine with potent oral antitumor activity

Bioorganic & medicinal chemistry, 2016-11, Vol.24 (22), p.5787-5795

2016

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Design, synthesis and biological evaluation of hybrid of ubenimex-fluorouracil for hepatocellular carcinoma therapy

Bioorganic chemistry, 2021-11, Vol.116, p.105343-105343, Article 105343

2021

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An optimized aptamer-binding viral tegument protein VP8 inhibits the production of Bovine Herpesvirus-1 through blocking nucleocytoplasmic shuttling

International journal of biological macromolecules, 2019-11, Vol.140, p.1226-1238

2019

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An Integrative Computational Approach to Evaluate Genetic Markers for Chronic Lymphocytic Leukemia

Journal of computational biology, 2017-09, Vol.24 (9), p.942-952

2017

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Advances and Challenges of HDAC Inhibitors in Cancer Therapeutics

Design, synthesis and anti-tumor activity study of novel histone deacetylase inhibitors containing isatin-based caps and o-phenylenediamine-based zinc binding groups

Discovery of a Novel Ubenimex Derivative as a First-in-Class Dual CD13/Proteasome Inhibitor for the Treatment of Cancer

Diversifying the anthracycline class of anti-cancer drugs identifies aclarubicin for superior survival of acute myeloid leukemia patients

A convenient guideline to determine if two Y-STR profiles are from the same lineage

Design, synthesis and biological evaluation of dual-function inhibitors targeting NMDAR and HDAC for Alzheimer’s disease

CDK7-dependent transcriptional addiction in bone and soft tissue sarcomas: Present and Future

EVA/KH560 synergistically modified recycled concrete mechanical properties - Experiment and molecular dynamics simulations

Nanomaterial-encapsulated dsRNA of ecdysone-induced early gene E75, a potential RNAi-based SIT strategy for pest control against Bactrocera dorsalis

WebCSEA: web-based cell-type-specific enrichment analysis of genes

Mesenchymal stem cell-derived extracellular vesicles accelerate diabetic wound healing by inhibiting NET-induced ferroptosis of endothelial cells

Discovery of novel biphenyl-sulfonamide analogues as NLRP3 inflammasome inhibitors

Environmental enrichment or selective activation of parvalbumin-expressing interneurons ameliorates synaptic and behavioral deficits in animal models with schizophrenia-like behaviors during adolescence

Concentration-dependent Effects of Nuclear Lamins on Nuclear Size in Xenopus and Mammalian Cells

Discovery of polymethoxyphenyl-pyridines bearing amino side chains as tubulin colchicine-binding site inhibitors

1,2-Isoselenazol-3(2H)-one derivatives as NDM-1 inhibitors displaying synergistic antimicrobial effects with meropenem on NDM-1 producing clinical isolates

Unbalanced ER‐mitochondrial calcium homeostasis promotes mitochondrial dysfunction and associated apoptotic pathways activation in methylmercury exposed rat cortical neurons

Tacrine-hydroxamate derivatives as multitarget-directed ligands for the treatment of Alzheimer’s disease: Design, synthesis, and biological evaluation

Development of N-hydroxybenzamide derivatives with indole-containing cap group as histone deacetylases inhibitors

Design, synthesis, and preliminary bioactivity evaluation of N 1 -hydroxyterephthalamide derivatives with indole cap as novel histone deacetylase inhibitors

Design, synthesis and preliminary evaluation of α-sulfonyl γ-(glycinyl-amino)proline peptidomimetics as matrix metalloproteinase inhibitors

Discovery of a novel chimeric ubenimex-gemcitabine with potent oral antitumor activity

Design, synthesis and biological evaluation of hybrid of ubenimex-fluorouracil for hepatocellular carcinoma therapy

An optimized aptamer-binding viral tegument protein VP8 inhibits the production of Bovine Herpesvirus-1 through blocking nucleocytoplasmic shuttling

An Integrative Computational Approach to Evaluate Genetic Markers for Chronic Lymphocytic Leukemia

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