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Salt-Inducible Kinases: Physiology, Regulation by cAMP, and Therapeutic Potential

Trends in endocrinology and metabolism, 2018-10, Vol.29 (10), p.723-735

2018

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Transcriptional block of AMPK-induced autophagy promotes glutamate excitotoxicity in nutrient-deprived SH-SY5Y neuroblastoma cells

Cellular and molecular life sciences : CMLS, 2020-09, Vol.77 (17), p.3383-3399

2020

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AMPK deficiency in smooth muscles causes persistent pulmonary hypertension of the new-born and premature death

Nature communications, 2022-08, Vol.13 (1), p.5034-5034, Article 5034

2022

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Salt-inducible kinases dictate parathyroid hormone 1 receptor action in bone development and remodeling

The Journal of clinical investigation, 2019-12, Vol.129 (12), p.5187-5203

2019

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Short-Term Overexpression of a Constitutively Active Form of AMP-Activated Protein Kinase in the Liver Leads to Mild Hypoglycemia and Fatty Liver

Diabetes (New York, N.Y.), 2005-05, Vol.54 (5), p.1331-1339

2005

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Acetyl-CoA Carboxylase Inhibitor CP640.186 Increases Tubulin Acetylation and Impairs Thrombin-Induced Platelet Aggregation

International journal of molecular sciences, 2021-12, Vol.22 (23), p.13129

2021

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Sterol Regulatory Element Binding Protein-1c Is a Major Mediator of Insulin Action on the Hepatic Expression of Glucokinase and Lipogenesis-Related Genes

Proceedings of the National Academy of Sciences - PNAS, 1999-10, Vol.96 (22), p.12737-12742

1999

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A role for AMP-activated protein kinase in diabetes-induced renal hypertrophy

American journal of physiology. Renal physiology, 2007-02, Vol.292 (2), p.F617-F627

2007

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Myeloid deletion and therapeutic activation of AMPK do not alter atherosclerosis in male or female mice

Journal of lipid research, 2020-12, Vol.61 (12), p.1697-1706

2020

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Finely-tuned regulation of AMP-activated protein kinase is crucial for human adult erythropoiesis

Haematologica (Roma), 2019-05, Vol.104 (5), p.907-918

2019

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Direct AMPK Activation Corrects NASH in Rodents Through Metabolic Effects and Direct Action on Inflammation and Fibrogenesis

Hepatology communications, 2022-01, Vol.6 (1), p.101-119

2022

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Exercise-induced molecular mechanisms promoting glycogen supercompensation in human skeletal muscle

Molecular metabolism (Germany), 2018-10, Vol.16, p.24-34

2018

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Metformin reduces macrophage HIF1α-dependent proinflammatory signaling to restore brown adipocyte function in vitro

Redox biology, 2021-12, Vol.48, p.102171-102171, Article 102171

2021

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Endothelial α1AMPK modulates angiotensin II-mediated vascular inflammation and dysfunction

Basic research in cardiology, 2019-03, Vol.114 (2), p.8-12, Article 8

2019

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Atrial AMP-activated protein kinase is critical for prevention of dysregulation of electrical excitability and atrial fibrillation

JCI insight, 2022-04, Vol.7 (8)

2022

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Role of Cardiac AMP-Activated Protein Kinase in a Non-pathological Setting: Evidence From Cardiomyocyte-Specific, Inducible AMP-Activated Protein Kinase α1α2-Knockout Mice

Frontiers in cell and developmental biology, 2021-10, Vol.9, p.731015-731015

2021

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Lack of Endothelial α1AMPK Reverses the Vascular Protective Effects of Exercise by Causing eNOS Uncoupling

Antioxidants, 2021-12, Vol.10 (12), p.1974

2021

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ADD1/SREBP-1c Is Required in the Activation of Hepatic Lipogenic Gene Expression by Glucose

Molecular and Cellular Biology, 1999-05, Vol.19 (5), p.3760-3768

1999

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AMP-activated Protein Kinase Inhibits the Glucose-activated Expression of Fatty Acid Synthase Gene in Rat Hepatocytes

The Journal of biological chemistry, 1998-06, Vol.273 (24), p.14767-14771

1998

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Glucose availability but not changes in pancreatic hormones sensitizes hepatic AMPK activity during nutritional transition in rodents

The Journal of biological chemistry, 2020-05, Vol.295 (18), p.5836-5849

2020

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Hypoglycemia-Sensing Neurons of the Ventromedial Hypothalamus Require AMPK-Induced Txn2 Expression but Are Dispensable for Physiological Counterregulation

Diabetes (New York, N.Y.), 2020-11, Vol.69 (11), p.2253-2266

2020

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Sterol Regulatory Element-binding Protein-1c Mimics the Negative Effect of Insulin on Phosphoenolpyruvate Carboxykinase (GTP) Gene Transcription

The Journal of biological chemistry, 2001-09, Vol.276 (37), p.34816-34823

2001

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Salt-inducible kinases regulate androgen synthesis in theca cells by enhancing CREB signaling

Molecular and cellular endocrinology, 2023-11, Vol.577, p.112030-112030, Article 112030

2023

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AMPK promotes induction of the tumor suppressor FLCN through activation of TFEB independently of mTOR

The FASEB journal, 2019-11, Vol.33 (11), p.12374-12391

2019

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Salt-Inducible Kinases: Physiology, Regulation by cAMP, and Therapeutic Potential

Transcriptional block of AMPK-induced autophagy promotes glutamate excitotoxicity in nutrient-deprived SH-SY5Y neuroblastoma cells

AMPK deficiency in smooth muscles causes persistent pulmonary hypertension of the new-born and premature death

Salt-inducible kinases dictate parathyroid hormone 1 receptor action in bone development and remodeling

Short-Term Overexpression of a Constitutively Active Form of AMP-Activated Protein Kinase in the Liver Leads to Mild Hypoglycemia and Fatty Liver

Acetyl-CoA Carboxylase Inhibitor CP640.186 Increases Tubulin Acetylation and Impairs Thrombin-Induced Platelet Aggregation

Sterol Regulatory Element Binding Protein-1c Is a Major Mediator of Insulin Action on the Hepatic Expression of Glucokinase and Lipogenesis-Related Genes

A role for AMP-activated protein kinase in diabetes-induced renal hypertrophy

Myeloid deletion and therapeutic activation of AMPK do not alter atherosclerosis in male or female mice

Finely-tuned regulation of AMP-activated protein kinase is crucial for human adult erythropoiesis

Dual targeting of salt inducible kinases and CSF1R uncouples bone formation and bone resorption

Direct AMPK Activation Corrects NASH in Rodents Through Metabolic Effects and Direct Action on Inflammation and Fibrogenesis

Exercise-induced molecular mechanisms promoting glycogen supercompensation in human skeletal muscle

Metformin reduces macrophage HIF1α-dependent proinflammatory signaling to restore brown adipocyte function in vitro

Endothelial α1AMPK modulates angiotensin II-mediated vascular inflammation and dysfunction

Atrial AMP-activated protein kinase is critical for prevention of dysregulation of electrical excitability and atrial fibrillation

Role of Cardiac AMP-Activated Protein Kinase in a Non-pathological Setting: Evidence From Cardiomyocyte-Specific, Inducible AMP-Activated Protein Kinase α1α2-Knockout Mice

Lack of Endothelial α1AMPK Reverses the Vascular Protective Effects of Exercise by Causing eNOS Uncoupling

ADD1/SREBP-1c Is Required in the Activation of Hepatic Lipogenic Gene Expression by Glucose

AMP-activated Protein Kinase Inhibits the Glucose-activated Expression of Fatty Acid Synthase Gene in Rat Hepatocytes

Glucose availability but not changes in pancreatic hormones sensitizes hepatic AMPK activity during nutritional transition in rodents

Hypoglycemia-Sensing Neurons of the Ventromedial Hypothalamus Require AMPK-Induced Txn2 Expression but Are Dispensable for Physiological Counterregulation

Sterol Regulatory Element-binding Protein-1c Mimics the Negative Effect of Insulin on Phosphoenolpyruvate Carboxykinase (GTP) Gene Transcription

Salt-inducible kinases regulate androgen synthesis in theca cells by enhancing CREB signaling

AMPK promotes induction of the tumor suppressor FLCN through activation of TFEB independently of mTOR

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