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Bulky “Gatekeeper” Residue Changes the Cosubstrate Specificity of Aminoglycoside 2″-Phosphotransferase IIa

Antimicrobial Agents and Chemotherapy, 2013-08, Vol.57 (8), p.3763-3766

2013

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The Crystal Structures of Substrate and Nucleotide Complexes of Enterococcus faecium Aminoglycoside-2′′-Phosphotransferase-IIa [APH(2′′)-IIa] Provide Insights into Substrate Selectivity in the APH(2′′) Subfamily

Journal of Bacteriology, 2009-07, Vol.191 (13), p.4133-4143

2009

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Catalytic Mechanism of Penicillin-Binding Protein 5 of Escherichia coli

Biochemistry (Easton), 2007-09, Vol.46 (35), p.10113-10121

2007

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Co-opting the Cell Wall in Fighting Methicillin-Resistant Staphylococcus aureus: Potent Inhibition of PBP 2a by Two Anti-MRSA β-Lactam Antibiotics

Journal of the American Chemical Society, 2008-07, Vol.130 (29), p.9212-9213

2008

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Structural basis for the diversity of the mechanism of nucleotide hydrolysis by the aminoglycoside‐2′′‐phosphotransferases

Acta crystallographica. Section D, Biological crystallography., 2019-12, Vol.75 (12), p.1129-1137

2019

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Mechanistic Basis for the Action of New Cephalosporin Antibiotics Effective against Methicillin- and Vancomycin-resistant Staphylococcus aureus

The Journal of biological chemistry, 2006-04, Vol.281 (15), p.10035-10041

2006

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The Basis for Resistance to β-Lactam Antibiotics by Penicillin-binding Protein 2a of Methicillin-resistant Staphylococcus aureus

The Journal of biological chemistry, 2004-09, Vol.279 (39), p.40802-40806

2004

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Crystal structure and kinetic mechanism of aminoglycoside phosphotransferase‐2″‐IVa

Protein science, 2010-08, Vol.19 (8), p.1565-1576

2010

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Structural Basis for Carbapenemase Activity of the OXA-23 β-Lactamase from Acinetobacter baumannii

Chemistry & biology, 2013-09, Vol.20 (9), p.1107-1115

2013

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Design of Novel Antibiotics that Bind to the Ribosomal Acyltransfer Site

Journal of the American Chemical Society, 2002-04, Vol.124 (13), p.3229-3237

2002

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Characterization of the β-Lactam Antibiotic Sensor Domain of the MecR1 Signal Sensor/Transducer Protein from Methicillin-Resistant Staphylococcus aureus

Biochemistry (Easton), 2007-07, Vol.46 (26), p.7822-7831

2007

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Structure of the bifunctional aminoglycoside-resistance enzyme AAC(6′)-Ie-APH(2′′)-Ia revealed by crystallographic and small-angle X-ray scattering analysis

Acta crystallographica. Section D, Biological crystallography., 2014-10, Vol.70 (10), p.2754-2764

2014

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Resistance to beta-lactam antibiotics and its mediation by the sensor domain of the transmembrane BlaR signaling pathway in Staphylococcus aureus

The Journal of biological chemistry, 2003-05, Vol.278 (20), p.18419-18425

2003

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The importance of a critical protonation state and the fate of the catalytic steps in class A beta-lactamases and penicillin-binding proteins

The Journal of biological chemistry, 2004-08, Vol.279 (33), p.34665-34673

2004

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Effects on substrate profile by mutational substitutions at positions 164 and 179 of the class A TEM(pUC19) beta-lactamase from Escherichia coli

The Journal of biological chemistry, 1999-08, Vol.274 (33), p.23052

1999

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Bulky “Gatekeeper” Residue Changes the Cosubstrate Specificity of Aminoglycoside 2″-Phosphotransferase IIa

The Crystal Structures of Substrate and Nucleotide Complexes of Enterococcus faecium Aminoglycoside-2′′-Phosphotransferase-IIa [APH(2′′)-IIa] Provide Insights into Substrate Selectivity in the APH(2′′) Subfamily

Catalytic Mechanism of Penicillin-Binding Protein 5 of Escherichia coli

Co-opting the Cell Wall in Fighting Methicillin-Resistant Staphylococcus aureus: Potent Inhibition of PBP 2a by Two Anti-MRSA β-Lactam Antibiotics

Structural basis for the diversity of the mechanism of nucleotide hydrolysis by the aminoglycoside‐2′′‐phosphotransferases

Mechanistic Basis for the Action of New Cephalosporin Antibiotics Effective against Methicillin- and Vancomycin-resistant Staphylococcus aureus

The Basis for Resistance to β-Lactam Antibiotics by Penicillin-binding Protein 2a of Methicillin-resistant Staphylococcus aureus

Crystal structure and kinetic mechanism of aminoglycoside phosphotransferase‐2″‐IVa

Structural Basis for Carbapenemase Activity of the OXA-23 β-Lactamase from Acinetobacter baumannii

Design of Novel Antibiotics that Bind to the Ribosomal Acyltransfer Site

Characterization of the β-Lactam Antibiotic Sensor Domain of the MecR1 Signal Sensor/Transducer Protein from Methicillin-Resistant Staphylococcus aureus

Structure of the bifunctional aminoglycoside-resistance enzyme AAC(6′)-Ie-APH(2′′)-Ia revealed by crystallographic and small-angle X-ray scattering analysis

Resistance to beta-lactam antibiotics and its mediation by the sensor domain of the transmembrane BlaR signaling pathway in Staphylococcus aureus

The importance of a critical protonation state and the fate of the catalytic steps in class A beta-lactamases and penicillin-binding proteins

Effects on substrate profile by mutational substitutions at positions 164 and 179 of the class A TEM(pUC19) beta-lactamase from Escherichia coli

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