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Predicting CD4 T-cell epitopes based on antigen cleavage, MHCII presentation, and TCR recognition

PloS one, 2018-11, Vol.13 (11), p.e0206654-e0206654

2018

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Subnanometre-resolution electron cryomicroscopy structure of a heterodimeric ABC exporter

Nature (London), 2015-01, Vol.517 (7534), p.396-400

2015

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Trapping Moving Targets with Small Molecules

Science (American Association for the Advancement of Science), 2009-04, Vol.324 (5924), p.213-215

2009

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Structure-function analysis of enterovirus protease 2A in complex with its essential host factor SETD3

Nature communications, 2022-09, Vol.13 (1), p.5282-5282, Article 5282

2022

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Structural basis of prostaglandin efflux by MRP4

Nature structural & molecular biology, 2024-04, Vol.31 (4), p.621-632

2024

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Immunoproteasome functions explained by divergence in cleavage specificity and regulation

eLife, 2017-11, Vol.6

2017

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Hepatocyte growth factor is a preferred in vitro substrate for human hepsin, a membrane-anchored serine protease implicated in prostate and ovarian cancers

Biochemical journal, 2005-08, Vol.390 (Pt 1), p.125-136

2005

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Elastin Degradation by Cathepsin V Requires Two Exosites

The Journal of biological chemistry, 2013-11, Vol.288 (48), p.34871-34881

2013

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Structural determinants of specificity and regulation of activity in the allosteric loop network of human KLK8/neuropsin

Scientific reports, 2018-07, Vol.8 (1), p.10705-15, Article 10705

2018

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Enzyme Inhibition by Allosteric Capture of an Inactive Conformation

Journal of molecular biology, 2011-09, Vol.411 (5), p.999-1016

2011

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Inhibition of a viral enzyme by a small-molecule dimer disruptor

Nature chemical biology, 2009-09, Vol.5 (9), p.640-646

2009

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Investigation of the proteolytic functions of an expanded cercarial elastase gene family in Schistosoma mansoni

PLoS neglected tropical diseases, 2012-04, Vol.6 (4), p.e1589-e1589

2012

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Excretion/secretion products from Schistosoma mansoni adults, eggs and schistosomula have unique peptidase specificity profiles

Biochimie, 2016-03, Vol.122, p.99-109

2016

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Granzyme M Is a Regulatory Protease That Inactivates Proteinase Inhibitor 9, an Endogenous Inhibitor of Granzyme B

The Journal of biological chemistry, 2004-12, Vol.279 (52), p.54275-54282

2004

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Structure of an Fab–Protease Complex Reveals a Highly Specific Non-canonical Mechanism of Inhibition

Journal of molecular biology, 2008-07, Vol.380 (2), p.351-360

2008

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Selective Inhibition of the Collagenolytic Activity of Human Cathepsin K by Altering Its S2 Subsite Specificity

Biochemistry (Easton), 2002-07, Vol.41 (26), p.8447-8454

2002

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Cellular Localization of Membrane-type Serine Protease 1 and Identification of Protease-activated Receptor-2 and Single-chain Urokinase-type Plasminogen Activator as Substrates

The Journal of biological chemistry, 2000-08, Vol.275 (34), p.26333-26342

2000

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Inhibition of a Secreted Glutamic Peptidase Prevents Growth of the Fungus Talaromyces emersonii

The Journal of biological chemistry, 2008-10, Vol.283 (43), p.29186-29195

2008

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Evolutionary Divergence of Substrate Specificity within the Chymotrypsin-like Serine Protease Fold

The Journal of biological chemistry, 1997-11, Vol.272 (48), p.29987-29990

1997

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Communication between the Active Sites and Dimer Interface of a Herpesvirus Protease Revealed by a Transition-State Inhibitor

Proceedings of the National Academy of Sciences - PNAS, 2004-05, Vol.101 (18), p.6870-6875

2004

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Structural basis of substrate specificity in the serine proteases

Protein science, 1995-03, Vol.4 (3), p.337-360

1995

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Induced structure of a helical switch as a mechanism to regulate enzymatic activity

Nature structural & molecular biology, 2005-11, Vol.12 (11), p.1019-1020

2005

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Anisotropic Dynamics of the JE-2147−HIV Protease Complex: Drug Resistance and Thermodynamic Binding Mode Examined in a 1.09 Å Structure

Biochemistry (Easton), 2002-04, Vol.41 (14), p.4582-4594

2002

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The structure of the pro-apoptotic protease granzyme B reveals the molecular determinants of its specificity

Nature structural & molecular biology, 2000-09, Vol.7 (9), p.762-765

2000

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Predicting CD4 T-cell epitopes based on antigen cleavage, MHCII presentation, and TCR recognition

Subnanometre-resolution electron cryomicroscopy structure of a heterodimeric ABC exporter

Trapping Moving Targets with Small Molecules

Structural insight into SARS-CoV-2 neutralizing antibodies and modulation of syncytia

Structure-function analysis of enterovirus protease 2A in complex with its essential host factor SETD3

Structural basis of prostaglandin efflux by MRP4

Immunoproteasome functions explained by divergence in cleavage specificity and regulation

Hepatocyte growth factor is a preferred in vitro substrate for human hepsin, a membrane-anchored serine protease implicated in prostate and ovarian cancers

Elastin Degradation by Cathepsin V Requires Two Exosites

Structural determinants of specificity and regulation of activity in the allosteric loop network of human KLK8/neuropsin

Enzyme Inhibition by Allosteric Capture of an Inactive Conformation

Inhibition of a viral enzyme by a small-molecule dimer disruptor

Investigation of the proteolytic functions of an expanded cercarial elastase gene family in Schistosoma mansoni

Excretion/secretion products from Schistosoma mansoni adults, eggs and schistosomula have unique peptidase specificity profiles

Granzyme M Is a Regulatory Protease That Inactivates Proteinase Inhibitor 9, an Endogenous Inhibitor of Granzyme B

Structure of an Fab–Protease Complex Reveals a Highly Specific Non-canonical Mechanism of Inhibition

Selective Inhibition of the Collagenolytic Activity of Human Cathepsin K by Altering Its S2 Subsite Specificity

Cellular Localization of Membrane-type Serine Protease 1 and Identification of Protease-activated Receptor-2 and Single-chain Urokinase-type Plasminogen Activator as Substrates

Inhibition of a Secreted Glutamic Peptidase Prevents Growth of the Fungus Talaromyces emersonii

Evolutionary Divergence of Substrate Specificity within the Chymotrypsin-like Serine Protease Fold

Communication between the Active Sites and Dimer Interface of a Herpesvirus Protease Revealed by a Transition-State Inhibitor

Structural basis of substrate specificity in the serine proteases

Induced structure of a helical switch as a mechanism to regulate enzymatic activity

Anisotropic Dynamics of the JE-2147−HIV Protease Complex: Drug Resistance and Thermodynamic Binding Mode Examined in a 1.09 Å Structure

The structure of the pro-apoptotic protease granzyme B reveals the molecular determinants of its specificity

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