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Role of hepatic efflux transporters in regulating systemic and hepatocyte exposure to xenobiotics

Annual review of pharmacology and toxicology, 2014-01, Vol.54 (1), p.509-535

2014

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Hepatic basolateral efflux contributes significantly to rosuvastatin disposition I: characterization of basolateral versus biliary clearance using a novel protocol in sandwich-cultured hepatocytes

The Journal of pharmacology and experimental therapeutics, 2013-12, Vol.347 (3), p.727

2013

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Hepatic basolateral efflux contributes significantly to rosuvastatin disposition II: characterization of hepatic elimination by basolateral, biliary, and metabolic clearance pathways in rat isolated perfused liver

The Journal of pharmacology and experimental therapeutics, 2013-12, Vol.347 (3), p.737

2013

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Mechanisms underlying differences in systemic exposure of structurally similar active metabolites: comparison of two preclinical hepatic models

The Journal of pharmacology and experimental therapeutics, 2011-05, Vol.337 (2), p.503

2011

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Decreased hepatic breast cancer resistance protein expression and function in multidrug resistance-associated protein 2-deficient (TR⁻) rats

Drug metabolism and disposition, 2011-03, Vol.39 (3), p.441

2011

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Use of cassette dosing in sandwich-cultured rat and human hepatocytes to identify drugs that inhibit bile acid transport

Toxicology in vitro, 2010-02, Vol.24 (1), p.297-309

2010

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Hepatobiliary disposition of troglitazone and metabolites in rat and human sandwich-cultured hepatocytes: use of Monte Carlo simulations to assess the impact of changes in biliary excretion on troglitazone sulfate accumulation

The Journal of pharmacology and experimental therapeutics, 2010-01, Vol.332 (1), p.26

2010

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Sex-dependent disposition of acetaminophen sulfate and glucuronide in the in situ perfused mouse liver

Drug metabolism and disposition, 2009-09, Vol.37 (9), p.1916

2009

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Use of Tc-99m Mebrofenin as a Clinical Probe to Assess Altered Hepatobiliary Transport: Integration of In Vitro, Pharmacokinetic Modeling, and Simulation Studies

Pharmaceutical research, 2008-08, Vol.25 (8), p.1851-1860

2008

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Impact of basolateral multidrug resistance-associated protein (Mrp) 3 and Mrp4 on the hepatobiliary disposition of fexofenadine in perfused mouse livers

Drug metabolism and disposition, 2008-05, Vol.36 (5), p.911

2008

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Modulation of trabectedin (ET-743) hepatobiliary disposition by multidrug resistance-associated proteins (Mrps) may prevent hepatotoxicity

Toxicology and applied pharmacology, 2008-04, Vol.228 (1), p.17-23

2008

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Multidrug resistance-associated protein 2 is primarily responsible for the biliary excretion of fexofenadine in mice

Drug metabolism and disposition, 2008-01, Vol.36 (1), p.61

2008

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Biotransformation and transport of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in bile duct-cannulated wild-type and Mrp2/Abcc2-deficient (TR−) Wistar rats

Carcinogenesis (New York), 2007-12, Vol.28 (12), p.2650-2656

2007

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Roles of P-Glycoprotein, Bcrp, and Mrp2 in Biliary Excretion of Spiramycin in Mice

Antimicrobial Agents and Chemotherapy, 2007-09, Vol.51 (9), p.3230-3234

2007

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Effect of DPC 333 [(2R)-2-{(3R)-3-amino-3-[4-(2-methylquinolin-4-ylmethoxy)phenyl]-2-oxopyrrolidin-1-yl}-N-hydroxy-4-methylpentanamide], a human tumor necrosis factor alpha-converting enzyme inhibitor, on the disposition of methotrexate: a transporter-based drug-drug interaction case study

Drug metabolism and disposition, 2007-06, Vol.35 (6), p.835

2007

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Evaluation of the role of multidrug resistance-associated protein (Mrp) 3 and Mrp4 in hepatic basolateral excretion of sulfate and glucuronide metabolites of acetaminophen, 4-methylumbelliferone, and harmol in Abcc3-/- and Abcc4-/- mice

The Journal of pharmacology and experimental therapeutics, 2006-12, Vol.319 (3), p.1485

2006

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Differential involvement of Mrp2 (Abcc2) and Bcrp (Abcg2) in biliary excretion of 4-methylumbelliferyl glucuronide and sulfate in the rat

The Journal of pharmacology and experimental therapeutics, 2006-10, Vol.319 (1), p.459

2006

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Determination of the biliary excretion of piperacillin in humans using a novel method

British journal of clinical pharmacology, 2006-09, Vol.62 (3), p.304-308

2006

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Hepatobiliary disposition of a drug/metabolite pair: Comprehensive pharmacokinetic modeling in sandwich-cultured rat hepatocytes

The Journal of pharmacology and experimental therapeutics, 2006-08, Vol.318 (2), p.881

2006

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Methods To Evaluate Biliary Excretion of Drugs in Humans: An Updated Review

Molecular pharmaceutics, 2006-05, Vol.3 (3), p.198-211

2006

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Integration of hepatic drug transporters and phase II metabolizing enzymes: Mechanisms of hepatic excretion of sulfate, glucuronide, and glutathione metabolites

European journal of pharmaceutical sciences, 2006-04, Vol.27 (5), p.447-486

2006

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Altered hepatobiliary disposition of 5 (and 6)-carboxy-2',7'-dichlorofluorescein in Abcg2 (Bcrp1) and Abcc2 (Mrp2) knockout mice

Drug metabolism and disposition, 2006-04, Vol.34 (4), p.718

2006

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Multiple mechanisms are involved in the biliary excretion of acetaminophen sulfate in the rat: role of Mrp2 and Bcrp1

Drug metabolism and disposition, 2005-08, Vol.33 (8), p.1158

2005

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Hepatobiliary disposition of the metabolically stable opioid peptide [D-Pen2, D-Pen5]-enkephalin (DPDPE): pharmacokinetic consequences of the interplay between multiple transport systems

The Journal of pharmacology and experimental therapeutics, 2004-12, Vol.311 (3), p.1203

2004

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A novel method for the determination of biliary clearance in humans

The AAPS journal, 2004-11, Vol.6 (4), p.e33

2004

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Role of hepatic efflux transporters in regulating systemic and hepatocyte exposure to xenobiotics

Hepatic basolateral efflux contributes significantly to rosuvastatin disposition I: characterization of basolateral versus biliary clearance using a novel protocol in sandwich-cultured hepatocytes

Hepatic basolateral efflux contributes significantly to rosuvastatin disposition II: characterization of hepatic elimination by basolateral, biliary, and metabolic clearance pathways in rat isolated perfused liver

Mechanisms underlying differences in systemic exposure of structurally similar active metabolites: comparison of two preclinical hepatic models

Decreased hepatic breast cancer resistance protein expression and function in multidrug resistance-associated protein 2-deficient (TR⁻) rats

Use of cassette dosing in sandwich-cultured rat and human hepatocytes to identify drugs that inhibit bile acid transport

Hepatobiliary disposition of troglitazone and metabolites in rat and human sandwich-cultured hepatocytes: use of Monte Carlo simulations to assess the impact of changes in biliary excretion on troglitazone sulfate accumulation

Sex-dependent disposition of acetaminophen sulfate and glucuronide in the in situ perfused mouse liver

Use of Tc-99m Mebrofenin as a Clinical Probe to Assess Altered Hepatobiliary Transport: Integration of In Vitro, Pharmacokinetic Modeling, and Simulation Studies

Impact of basolateral multidrug resistance-associated protein (Mrp) 3 and Mrp4 on the hepatobiliary disposition of fexofenadine in perfused mouse livers

Modulation of trabectedin (ET-743) hepatobiliary disposition by multidrug resistance-associated proteins (Mrps) may prevent hepatotoxicity

Multidrug resistance-associated protein 2 is primarily responsible for the biliary excretion of fexofenadine in mice

Biotransformation and transport of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in bile duct-cannulated wild-type and Mrp2/Abcc2-deficient (TR−) Wistar rats

Roles of P-Glycoprotein, Bcrp, and Mrp2 in Biliary Excretion of Spiramycin in Mice

Effect of DPC 333 [(2R)-2-{(3R)-3-amino-3-[4-(2-methylquinolin-4-ylmethoxy)phenyl]-2-oxopyrrolidin-1-yl}-N-hydroxy-4-methylpentanamide], a human tumor necrosis factor alpha-converting enzyme inhibitor, on the disposition of methotrexate: a transporter-based drug-drug interaction case study

Evaluation of the role of multidrug resistance-associated protein (Mrp) 3 and Mrp4 in hepatic basolateral excretion of sulfate and glucuronide metabolites of acetaminophen, 4-methylumbelliferone, and harmol in Abcc3-/- and Abcc4-/- mice

Differential involvement of Mrp2 (Abcc2) and Bcrp (Abcg2) in biliary excretion of 4-methylumbelliferyl glucuronide and sulfate in the rat

Determination of the biliary excretion of piperacillin in humans using a novel method

Hepatobiliary disposition of a drug/metabolite pair: Comprehensive pharmacokinetic modeling in sandwich-cultured rat hepatocytes

Methods To Evaluate Biliary Excretion of Drugs in Humans: An Updated Review

Integration of hepatic drug transporters and phase II metabolizing enzymes: Mechanisms of hepatic excretion of sulfate, glucuronide, and glutathione metabolites

Altered hepatobiliary disposition of 5 (and 6)-carboxy-2',7'-dichlorofluorescein in Abcg2 (Bcrp1) and Abcc2 (Mrp2) knockout mice

Multiple mechanisms are involved in the biliary excretion of acetaminophen sulfate in the rat: role of Mrp2 and Bcrp1

Hepatobiliary disposition of the metabolically stable opioid peptide [D-Pen2, D-Pen5]-enkephalin (DPDPE): pharmacokinetic consequences of the interplay between multiple transport systems

A novel method for the determination of biliary clearance in humans

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