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Distinct G protein-coupled receptor phosphorylation motifs modulate arrestin affinity and activation and global conformation

Nature communications, 2019-03, Vol.10 (1), p.1261-1261, Article 1261

2019

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Carfentanil is a β‐arrestin‐biased agonist at the μ opioid receptor

British journal of pharmacology, 2023-09, Vol.180 (18), p.2341-2360

2023

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β-Arrestin mediates the Frank–Starling mechanism of cardiac contractility

Proceedings of the National Academy of Sciences - PNAS, 2016-12, Vol.113 (50), p.14426-14431

2016

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Regulation of cardiac fibroblast-mediated maladaptive ventricular remodeling by β-arrestins

PloS one, 2019-07, Vol.14 (7), p.e0219011-e0219011

2019

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Conformational Dynamics and Functional Implications of Phosphorylated β-Arrestins

Structure (London), 2020-03, Vol.28 (3), p.314-323.e3

2020

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Structure of active β-arrestin-1 bound to a G-protein-coupled receptor phosphopeptide

Nature (London), 2013-05, Vol.497 (7447), p.137-141

2013

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Disrupted circadian expression of β‐arrestin 2 affects reward‐related µ‐opioid receptor function in alcohol dependence

Journal of neurochemistry, 2022-02, Vol.160 (4), p.454-468

2022

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β-arrestin signaling and regulation of transcription

Journal of cell science, 2007-01, Vol.120 (2), p.213-218

2007

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β-arrestin 2 mediates cardiac ischemia-reperfusion injury via inhibiting GPCR-independent cell survival signalling

Cardiovascular research, 2017-11, Vol.113 (13), p.1615-1626

2017

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β-Arrestin-biased AT1R stimulation promotes extracellular matrix synthesis in renal fibrosis

American journal of physiology. Renal physiology, 2017-07, Vol.313 (1), p.F1-F8

2017

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Circulating Exosomes Induced by Cardiac Pressure Overload Contain Functional Angiotensin II Type 1 Receptors

Circulation (New York, N.Y.), 2015-06, Vol.131 (24), p.2120-2130

2015

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High-mass MALDI-MS unravels ligand-mediated G protein–coupling selectivity to GPCRs

Proceedings of the National Academy of Sciences - PNAS, 2021-08, Vol.118 (31), p.1-9

2021

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β‐Arrestin‐biased proteinase‐activated receptor‐2 antagonist C781 limits allergen‐induced airway hyperresponsiveness and inflammation

British journal of pharmacology, 2023-03, Vol.180 (5), p.667-680

2023

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Scaffolding mechanism of arrestin-2 in the cRaf/MEK1/ERK signaling cascade

Proceedings of the National Academy of Sciences - PNAS, 2021-09, Vol.118 (37), p.1-11

2021

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β-arrestin-1 is a nuclear transcriptional regulator of endothelin-1-induced β-catenin signaling

Oncogene, 2013-10, Vol.32 (42), p.5066-5077

2013

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β-Arrestin Recruitment and Biased Agonism at Free Fatty Acid Receptor 1

The Journal of biological chemistry, 2015-08, Vol.290 (34), p.21131-21140

2015

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Biased GLP‐2 agonist with strong G protein‐coupling but impaired arrestin recruitment and receptor desensitization enhances intestinal growth in mice

British journal of pharmacology, 2023-07, Vol.180 (13), p.1674-1689

2023

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The β-Arrestins: Multifunctional Regulators of G Protein-coupled Receptors

The Journal of biological chemistry, 2016-04, Vol.291 (17), p.8969-8977

2016

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A β-arrestin 2 Signaling Complex Mediates Lithium Action on Behavior

Cell, 2008-01, Vol.132 (1), p.125-136

2008

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The molecular associations in clathrin-coated pit regulate β-arrestin-mediated MAPK signaling downstream of μ-opioid receptor

Biochemical and biophysical research communications, 2023-01, Vol.640, p.64-72

2023

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Mechanisms of rapid opioid receptor desensitization, resensitization and tolerance in brain neurons

British journal of pharmacology, 2012-03, Vol.165 (6), p.1704-1716

2012

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Specificity of arrestin subtypes in regulating airway smooth muscle G protein‐coupled receptor signaling and function

The FASEB journal, 2015-10, Vol.29 (10), p.4227-4235

2015

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Structural Basis of Arrestin-Dependent Signal Transduction

Trends in biochemical sciences (Amsterdam. Regular ed.), 2018-06, Vol.43 (6), p.412-423

2018

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β-arrestin2 mediates the hippocampal dopaminergic system in autistic mouse through the ERK signaling pathway

Behavioural brain research, 2022-06, Vol.428, p.113888-113888, Article 113888

2022

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Biased versus Partial Agonism in the Search for Safer Opioid Analgesics

Molecules (Basel, Switzerland), 2020-08, Vol.25 (17), p.3870

2020

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Distinct G protein-coupled receptor phosphorylation motifs modulate arrestin affinity and activation and global conformation

Carfentanil is a β‐arrestin‐biased agonist at the μ opioid receptor

β-Arrestin mediates the Frank–Starling mechanism of cardiac contractility

Regulation of cardiac fibroblast-mediated maladaptive ventricular remodeling by β-arrestins

Conformational Dynamics and Functional Implications of Phosphorylated β-Arrestins

Structure of active β-arrestin-1 bound to a G-protein-coupled receptor phosphopeptide

Disrupted circadian expression of β‐arrestin 2 affects reward‐related µ‐opioid receptor function in alcohol dependence

β-arrestin signaling and regulation of transcription

β-arrestin 2 mediates cardiac ischemia-reperfusion injury via inhibiting GPCR-independent cell survival signalling

β-Arrestin-biased AT1R stimulation promotes extracellular matrix synthesis in renal fibrosis

Circulating Exosomes Induced by Cardiac Pressure Overload Contain Functional Angiotensin II Type 1 Receptors

High-mass MALDI-MS unravels ligand-mediated G protein–coupling selectivity to GPCRs

β‐Arrestin‐biased proteinase‐activated receptor‐2 antagonist C781 limits allergen‐induced airway hyperresponsiveness and inflammation

Scaffolding mechanism of arrestin-2 in the cRaf/MEK1/ERK signaling cascade

β-arrestin-1 is a nuclear transcriptional regulator of endothelin-1-induced β-catenin signaling

β-Arrestin Recruitment and Biased Agonism at Free Fatty Acid Receptor 1

Biased GLP‐2 agonist with strong G protein‐coupling but impaired arrestin recruitment and receptor desensitization enhances intestinal growth in mice

The β-Arrestins: Multifunctional Regulators of G Protein-coupled Receptors

A β-arrestin 2 Signaling Complex Mediates Lithium Action on Behavior

The molecular associations in clathrin-coated pit regulate β-arrestin-mediated MAPK signaling downstream of μ-opioid receptor

Mechanisms of rapid opioid receptor desensitization, resensitization and tolerance in brain neurons

Specificity of arrestin subtypes in regulating airway smooth muscle G protein‐coupled receptor signaling and function

Structural Basis of Arrestin-Dependent Signal Transduction

β-arrestin2 mediates the hippocampal dopaminergic system in autistic mouse through the ERK signaling pathway

Biased versus Partial Agonism in the Search for Safer Opioid Analgesics

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