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Liposomal honokiol induced lysosomal degradation of Hsp90 client proteins and protective autophagy in both gefitinib-sensitive and gefitinib-resistant NSCLC cells

Biomaterials, 2017-10, Vol.141, p.188-198

2017

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Studies on the anti-psoriasis effects and its mechanism of a dual JAK2/FLT3 inhibitor flonoltinib maleate

Biomedicine & pharmacotherapy, 2021-05, Vol.137, p.111373-111373, Article 111373

2021

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SKLB-23bb, A HDAC6-Selective Inhibitor, Exhibits Superior and Broad-Spectrum Antitumor Activity via Additionally Targeting Microtubules

Molecular cancer therapeutics, 2018-04, Vol.17 (4), p.763-775

2018

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SKLB060 Reversibly Binds to Colchicine Site of Tubulin and Possesses Efficacy in Multidrug-Resistant Cell Lines

Cellular physiology and biochemistry, 2018-01, Vol.47 (2), p.489-504

2018

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Barbigerone, an isoflavone, inhibits tumor angiogenesis and human non-small-cell lung cancer xenografts growth through VEGFR2 signaling pathways

Cancer chemotherapy and pharmacology, 2012-09, Vol.70 (3), p.425-437

2012

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Non-toxic dose of liposomal honokiol suppresses metastasis of hepatocellular carcinoma through destabilizing EGFR and inhibiting the downstream pathways

Oncotarget, 2017-01, Vol.8 (1), p.915-932

2017

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Deguelin—An inhibitor to tumor lymphangiogenesis and lymphatic metastasis by downregulation of vascular endothelial cell growth factor‐D in lung tumor model

International journal of cancer, 2010-11, Vol.127 (10), p.2455-2466

2010

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Rational design, synthesis, and pharmacological properties of pyranochalcone derivatives as potent anti-inflammatory agents

European journal of medicinal chemistry, 2012-08, Vol.54, p.272-280

2012

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Herb-sourced emodin inhibits angiogenesis of breast cancer by targeting VEGFA transcription

Theranostics, 2020-01, Vol.10 (15), p.6839-6853

2020

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Millepachine showed novel antitumor effects in cisplatin‐resistant human ovarian cancer through inhibiting drug efflux function of ATP‐binding cassette transporters

Phytotherapy research, 2018-12, Vol.32 (12), p.2428-2435

2018

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From lead to clinic: A review of the structural design of P2X7R antagonists

European journal of medicinal chemistry, 2023-05, Vol.251, p.115234-115234, Article 115234

2023

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Ethanol extract of Liriodendron chinense (Hemsl.) Sarg barks attenuates hyperuricemic nephropathy by inhibiting renal fibrosis and inflammation in mice

Journal of ethnopharmacology, 2021-01, Vol.264, p.113278-113278, Article 113278

2021

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Identification and optimization of piperine analogues as neuroprotective agents for the treatment of Parkinson’s disease via the activation of Nrf2/keap1 pathway

European journal of medicinal chemistry, 2020-08, Vol.199, p.112385, Article 112385

2020

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UPLC-MS/MS method development and application to pharmacokinetic study in rats and dogs of Flonoltinib Maleat

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2023-05, Vol.1223, p.123696-123696, Article 123696

2023

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Design, Synthesis, and Bioactivity Evaluation of Dual-Target Inhibitors of Tubulin and Src Kinase Guided by Crystal Structure

Journal of medicinal chemistry, 2021-06, Vol.64 (12), p.8127-8141

2021

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Discovery and synthesis of novel magnolol derivatives with potent anticancer activity in non-small cell lung cancer

European journal of medicinal chemistry, 2018-08, Vol.156, p.190-205

2018

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Discovery of a Series of Hydroxamic Acid-Based Microtubule Destabilizing Agents with Potent Antitumor Activity

Journal of medicinal chemistry, 2021-10, Vol.64 (20), p.15379-15401

2021

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Structural exploration, synthesis and pharmacological evaluation of novel 5-benzylidenethiazolidine-2,4-dione derivatives as iNOS inhibitors against inflammatory diseases

European journal of medicinal chemistry, 2015-03, Vol.92, p.178-190

2015

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Synthesis and discovery of new compounds bearing coumarin scaffold for the treatment of pulmonary fibrosis

European journal of medicinal chemistry, 2020-01, Vol.185, p.111790-111790, Article 111790

2020

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Anti-inflammatory activity of ethyl acetate fraction of the seeds of Brucea Javanica

Journal of ethnopharmacology, 2013-05, Vol.147 (2), p.442-446

2013

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Structure-Based Design and Synthesis of N‑Substituted 3‑Amino-β-Carboline Derivatives as Potent αβ-Tubulin Degradation Agents

Journal of medicinal chemistry, 2022-02, Vol.65 (3), p.2675-2693

2022

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Metabolic profiling in liver microsomes and mice of E28, a potent FLT3 inhibitor

Xenobiotica, 2022-02, Vol.52 (2), p.186-198

2022

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Millepachine, a novel chalcone, induces G2/M arrest by inhibiting CDK1 activity and causing apoptosis via ROS-mitochondrial apoptotic pathway in human hepatocarcinoma cells in vitro and in vivo

Carcinogenesis (New York), 2013-07, Vol.34 (7), p.1636

2013

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Millepachine, a potential topoisomerase II inhibitor induces apoptosis via activation of NF-κB pathway in ovarian cancer

Oncotarget, 2016-08, Vol.7 (32), p.52281-52293

2016

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PEG-derivatized birinapant as a nanomicellar carrier of paclitaxel delivery for cancer therapy

Colloids and surfaces, B, Biointerfaces, 2019-10, Vol.182, p.110356-110356, Article 110356

2019

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Liposomal honokiol induced lysosomal degradation of Hsp90 client proteins and protective autophagy in both gefitinib-sensitive and gefitinib-resistant NSCLC cells

Studies on the anti-psoriasis effects and its mechanism of a dual JAK2/FLT3 inhibitor flonoltinib maleate

SKLB-23bb, A HDAC6-Selective Inhibitor, Exhibits Superior and Broad-Spectrum Antitumor Activity via Additionally Targeting Microtubules

SKLB060 Reversibly Binds to Colchicine Site of Tubulin and Possesses Efficacy in Multidrug-Resistant Cell Lines

Barbigerone, an isoflavone, inhibits tumor angiogenesis and human non-small-cell lung cancer xenografts growth through VEGFR2 signaling pathways

Non-toxic dose of liposomal honokiol suppresses metastasis of hepatocellular carcinoma through destabilizing EGFR and inhibiting the downstream pathways

Deguelin—An inhibitor to tumor lymphangiogenesis and lymphatic metastasis by downregulation of vascular endothelial cell growth factor‐D in lung tumor model

Rational design, synthesis, and pharmacological properties of pyranochalcone derivatives as potent anti-inflammatory agents

Herb-sourced emodin inhibits angiogenesis of breast cancer by targeting VEGFA transcription

Millepachine showed novel antitumor effects in cisplatin‐resistant human ovarian cancer through inhibiting drug efflux function of ATP‐binding cassette transporters

From lead to clinic: A review of the structural design of P2X7R antagonists

Ethanol extract of Liriodendron chinense (Hemsl.) Sarg barks attenuates hyperuricemic nephropathy by inhibiting renal fibrosis and inflammation in mice

Identification and optimization of piperine analogues as neuroprotective agents for the treatment of Parkinson’s disease via the activation of Nrf2/keap1 pathway

UPLC-MS/MS method development and application to pharmacokinetic study in rats and dogs of Flonoltinib Maleat

Design, Synthesis, and Bioactivity Evaluation of Dual-Target Inhibitors of Tubulin and Src Kinase Guided by Crystal Structure

Discovery and synthesis of novel magnolol derivatives with potent anticancer activity in non-small cell lung cancer

Discovery of a Series of Hydroxamic Acid-Based Microtubule Destabilizing Agents with Potent Antitumor Activity

Structural exploration, synthesis and pharmacological evaluation of novel 5-benzylidenethiazolidine-2,4-dione derivatives as iNOS inhibitors against inflammatory diseases

Synthesis and discovery of new compounds bearing coumarin scaffold for the treatment of pulmonary fibrosis

Anti-inflammatory activity of ethyl acetate fraction of the seeds of Brucea Javanica

Structure-Based Design and Synthesis of N‑Substituted 3‑Amino-β-Carboline Derivatives as Potent αβ-Tubulin Degradation Agents

Metabolic profiling in liver microsomes and mice of E28, a potent FLT3 inhibitor

Millepachine, a novel chalcone, induces G2/M arrest by inhibiting CDK1 activity and causing apoptosis via ROS-mitochondrial apoptotic pathway in human hepatocarcinoma cells in vitro and in vivo

Millepachine, a potential topoisomerase II inhibitor induces apoptosis via activation of NF-κB pathway in ovarian cancer

PEG-derivatized birinapant as a nanomicellar carrier of paclitaxel delivery for cancer therapy

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