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New Tacrine−Huperzine A Hybrids (Huprines): Highly Potent Tight-Binding Acetylcholinesterase Inhibitors of Interest for the Treatment of Alzheimer's Disease

Journal of medicinal chemistry, 2000-11, Vol.43 (24), p.4657-4666

2000

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Synthesis, in Vitro Pharmacology, and Molecular Modeling of syn-Huprines as Acetylcholinesterase Inhibitors

Journal of medicinal chemistry, 2001-12, Vol.44 (26), p.4733-4736

2001

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Synthesis, in Vitro Pharmacology, and Molecular Modeling of Very Potent Tacrine−Huperzine A Hybrids as Acetylcholinesterase Inhibitors of Potential Interest for the Treatment of Alzheimer's Disease

Journal of medicinal chemistry, 1999-08, Vol.42 (17), p.3227-3242

1999

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Interaction of a new potent anticholinesterasic compound (±)huprine X with muscarinic receptors in rat brain

Neuroscience letters, 2002-06, Vol.325 (2), p.103-106

2002

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Effects of (±)-huprine Y and (±)-huprine Z, two new anticholinesterasic drugs, on muscarinic receptors

Neuroscience letters, 2005-05, Vol.379 (2), p.106-109

2005

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Characterisation of the anticholinesterase activity of two new tacrine–huperzine A hybrids

Neuropharmacology, 2003-05, Vol.44 (6), p.749-755

2003

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Synthesis and evaluation of tacrine-huperzine A hybrids as acetylcholinesterase inhibitors of potential interest for the treatment of Alzheimer's disease

Bioorganic & medicinal chemistry, 1998-04, Vol.6 (4), p.427-440

1998

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Early Environmental Stimulation Produces Long-Lasting Changes on β-Adrenoceptor Transduction System

Neurobiology of learning and memory, 1995-07, Vol.64 (1), p.49-57

1995

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D2 dopamine receptors and modulation of spontaneous acetylcholine (ACh) release from rat striatal synaptosomes

British journal of pharmacology, 1997-09, Vol.122 (2), p.286-290

1997

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Action on noradrenergic transmission of an anticholinesterase: 9-amino-1,2,3,4-tetrahydroacridine

Neuropharmacology, 1995-04, Vol.34 (4), p.367-375

1995

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Assessing the (a)symmetry of concentration-effect curves: empirical versus mechanistic models

Pharmacology & therapeutics (Oxford), 2002-07, Vol.95 (1), p.21-45

2002

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Sources of calcium and alpha 1-adrenoceptor-mediated contraction in rat tail artery

British journal of pharmacology, 1996-08, Vol.118 (8), p.2067-2072

1996

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Differential effects of physostigmine and 1,2,3,4-tetrahydro-9-aminoacridine on the β-adrenoceptor transduction system

European journal of pharmacology, 1993-03, Vol.245 (1), p.9-13

1993

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Endothelial modulation of alpha 1-adrenoceptor contractile responses in the tail artery of spontaneously hypertensive rats

British journal of pharmacology, 1996-10, Vol.119 (4), p.765-771

1996

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Study of the mechanism of the relaxant action of (+)‐glaucine in rat vas deferens

British journal of pharmacology, 1993-11, Vol.110 (3), p.943-948

1993

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Post-train administration of 9-amino-1,2,3,4-tetrahydroacridine enhances passive avoidance retention and decreases β-adrenoceptor-linked cyclic AMP formation in middle-aged rats

Brain research, 1992-07, Vol.586 (1), p.117-120

1992

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Acute effects of tetrahydroaminoacridine on β-adrenoceptor-linked cyclic AMP accumulation in brain of young and middle-aged rats

Neuroscience letters, 1991-10, Vol.132 (1), p.51-54

1991

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Different alpha1-adrenoceptor-induced inositol phosphate formation in the two portions of rat vas deferens

Naunyn-Schmiedeberg's archives of pharmacology, 2001-01, Vol.363 (1), p.11-15

2001

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Alpha 1-adrenoceptor vasoconstriction in the tail artery during ageing

British journal of pharmacology, 1997-07, Vol.121 (5), p.1017-1023

1997

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Use of the operational model of agonism and [3H]prazosin binding to assess altered responsiveness of alpha1-adrenoceptors in the vas deferens of spontaneously hypertensive rat

Naunyn-Schmiedeberg's archives of pharmacology, 1997-09, Vol.356 (3), p.383-391

1997

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Effects of age on alpha 1-adrenoceptor subtypes in the heart ventricular muscle of the rat

Journal of pharmacy and pharmacology, 1993-10, Vol.45 (10), p.907

1993

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Strategies for the control of Rhipicephalus microplus ticks in a world of conventional acaricide and macrocyclic lactone resistance

Parasitology research (1987), 2018-01, Vol.117 (1), p.3-29

2018

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Cell type-specific changes in transcriptomic profiles of endothelial cells, iPSC-derived neurons and astrocytes cultured on microfluidic chips

Scientific reports, 2021-01, Vol.11 (1), p.2281-2281, Article 2281

2021

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Brain Targeted Gold Liposomes Improve RNAi Delivery for Glioblastoma

International journal of nanomedicine, 2020-01, Vol.15, p.2809-2828

2020

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Targeting c-MYC in Platinum-Resistant Ovarian Cancer

Molecular cancer therapeutics, 2015-10, Vol.14 (10), p.2260-2269

2015

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New Tacrine−Huperzine A Hybrids (Huprines): Highly Potent Tight-Binding Acetylcholinesterase Inhibitors of Interest for the Treatment of Alzheimer's Disease

Synthesis, in Vitro Pharmacology, and Molecular Modeling of syn-Huprines as Acetylcholinesterase Inhibitors

Synthesis, in Vitro Pharmacology, and Molecular Modeling of Very Potent Tacrine−Huperzine A Hybrids as Acetylcholinesterase Inhibitors of Potential Interest for the Treatment of Alzheimer's Disease

Interaction of a new potent anticholinesterasic compound (±)huprine X with muscarinic receptors in rat brain

Effects of (±)-huprine Y and (±)-huprine Z, two new anticholinesterasic drugs, on muscarinic receptors

Characterisation of the anticholinesterase activity of two new tacrine–huperzine A hybrids

Synthesis and evaluation of tacrine-huperzine A hybrids as acetylcholinesterase inhibitors of potential interest for the treatment of Alzheimer's disease

Early Environmental Stimulation Produces Long-Lasting Changes on β-Adrenoceptor Transduction System

D2 dopamine receptors and modulation of spontaneous acetylcholine (ACh) release from rat striatal synaptosomes

Action on noradrenergic transmission of an anticholinesterase: 9-amino-1,2,3,4-tetrahydroacridine

Assessing the (a)symmetry of concentration-effect curves: empirical versus mechanistic models

Sources of calcium and alpha 1-adrenoceptor-mediated contraction in rat tail artery

Differential effects of physostigmine and 1,2,3,4-tetrahydro-9-aminoacridine on the β-adrenoceptor transduction system

Endothelial modulation of alpha 1-adrenoceptor contractile responses in the tail artery of spontaneously hypertensive rats

Study of the mechanism of the relaxant action of (+)‐glaucine in rat vas deferens

Post-train administration of 9-amino-1,2,3,4-tetrahydroacridine enhances passive avoidance retention and decreases β-adrenoceptor-linked cyclic AMP formation in middle-aged rats

Acute effects of tetrahydroaminoacridine on β-adrenoceptor-linked cyclic AMP accumulation in brain of young and middle-aged rats

Different alpha1-adrenoceptor-induced inositol phosphate formation in the two portions of rat vas deferens

Alpha 1-adrenoceptor vasoconstriction in the tail artery during ageing

Use of the operational model of agonism and [3H]prazosin binding to assess altered responsiveness of alpha1-adrenoceptors in the vas deferens of spontaneously hypertensive rat

Effects of age on alpha 1-adrenoceptor subtypes in the heart ventricular muscle of the rat

Strategies for the control of Rhipicephalus microplus ticks in a world of conventional acaricide and macrocyclic lactone resistance

Cell type-specific changes in transcriptomic profiles of endothelial cells, iPSC-derived neurons and astrocytes cultured on microfluidic chips

Brain Targeted Gold Liposomes Improve RNAi Delivery for Glioblastoma

Targeting c-MYC in Platinum-Resistant Ovarian Cancer

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