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Pharmacokinetic/pharmacodynamic modeling in drug development

Annual review of pharmacology and toxicology, 2000-01, Vol.40 (1), p.67-95

2000

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Modelling response time profiles in the absence of drug concentrations: definition and performance evaluation of the K-PD model

Journal of pharmacokinetics and pharmacodynamics, 2007-02, Vol.34 (1), p.57-85

2007

Volltextzugriff (PDF)

Sparse sampling for assessment of drug exposure in toxicological studies

European journal of drug metabolism and pharmacokinetics, 1996-04, Vol.21 (2), p.105-111

1996

Volltextzugriff (PDF)

Simultaneous Pharmacokinetic Modeling of a Drug and Two Metabolites: Application to Albendazole in Sheep

Journal of pharmaceutical sciences, 1991-01, Vol.80 (1), p.3-10

1991

Volltextzugriff (PDF)

Feedback control methods for drug dosage optimisation. Concepts, classification and clinical application

Clinical pharmacokinetics, 1985-01, Vol.10 (6), p.457-476

1985

Volltextzugriff (PDF)

Effect of adrenalectomy and aldosterone on the modulation of mineralocorticoid receptors in rat kidney

The Journal of biological chemistry, 1981-01, Vol.256 (1), p.142-147

1981

Volltextzugriff (PDF)

Physiologically based pharmacokinetic study on a cyclosporin derivative, SDZ IMM 125

Journal of pharmacokinetics and biopharmaceutics, 1994-10, Vol.22 (5), p.327-365

1994

Volltextzugriff (PDF)

Cytoplasmic and nuclear uptake of aldosterone in toad bladder: a mathematical modeling approach

American Journal of Physiology: Cell Physiology, 1985-01, Vol.248 (1), p.C88-C101

1985

Volltextzugriff (PDF)

A mathematical model of the kinetics of 5-fluorouracil and its catabolites in freshly isolated rat hepatocytes

Biochemical pharmacology, 1984-09, Vol.33 (17), p.2727-2732

1984

Volltextzugriff (PDF)

Clinical pharmacokinetic/pharmacodynamic and physiologically based pharmacokinetic modeling in new drug development: the capecitabine experience

Investigational new drugs, 2003-05, Vol.21 (2), p.195-223

2003

Volltextzugriff (PDF)

Isoniazid plasma and lymph kinetics after intravenous injection in dogs

Arzneimittel-Forschung, 1984, Vol.34 (10), p.1283

1984

Volltextzugriff (PDF)

A non-linear mathematical model for the in vivo determination of Kupffer cells number and rate of phagocytosis of radiocolloids in rats

International journal of bio-medical computing, 1979-08, Vol.10 (4), p.331-340

1979

Volltextzugriff (PDF)

The passive coping Roman Low Avoidance rat, a non-obese rat model for insulin resistance

Physiology & behavior, 2009-06, Vol.97 (3), p.353-358

2009

Volltextzugriff (PDF)

Native but not denatured recombinant human immunodeficiency virus type 1 gp120 generates broad-spectrum neutralizing antibodies in baboons

Journal of Virology, 1992-01, Vol.66 (1), p.172-182

1992

Volltextzugriff (PDF)

Long-term protection of chimpanzees against high-dose HIV-1 challenge induced by immunization

Nature medicine, 1997-06, Vol.3 (6), p.651-658

1997

Volltextzugriff (PDF)

Maternal Monoclonal Antibody to the V3 Loop Alters Specificity of the Response to a Human Immunodeficiency Virus Vaccine

The Journal of infectious diseases, 1996-10, Vol.174 (4), p.866-869

1996

Volltextzugriff (PDF)

Expression and processing of biologically active fibroblast growth factors in the yeast Saccharomyces cerevisiae

The Journal of biological chemistry, 1988-11, Vol.263 (31), p.16471-16478

1988

Volltextzugriff (PDF)

Resistance of chimpanzees immunized with recombinant gp120SF2 to challenge by HIV-1SF2

AIDS (London), 1995-12, Vol.9 (12), p.1313-1322

1995

Volltextzugriff (PDF)

Inhibition of the offspring anti-recombinant gp120 antibody response to a human immunodeficiency virus vaccine by maternal immunization in a murine model

The Journal of infectious diseases, 1995-08, Vol.172 (2), p.539

1995

Volltextzugriff (PDF)

Importance of hypervariable regions of HIV-1 gp120 in the generation of virus neutralizing antibodies

AIDS research and human retroviruses, 1990-07, Vol.6 (7), p.855-869

1990

Volltextzugriff (PDF)

Antibodies are produced to the variable regions of the external envelope glycoprotein of human immunodeficiency virus type 1 in chimpanzees infected with the virus and baboons immunized with a candidate recombinant vaccine

Journal of general virology, 1992-05, Vol.73 (5), p.1099-1106

1992

Volltextzugriff (PDF)

Nonaffinity purification of recombinant gp120 for use in AIDS vaccine development

AIDS research and human retroviruses, 1993-12, Vol.9 (12), p.1233-1244

1993

Volltextzugriff (PDF)

HIV hyperimmune globulin or intravenous immune globulin inhibits response to an HIV vaccine

Biotechnology and applied biochemistry, 1998-04, Vol.27 (2), p.89-95

1998

Volltextzugriff (PDF)

Infection by the retrovirus associated with the acquired immunodeficiency syndrome. Clinical, biological, and molecular features

Annals of internal medicine, 1985-11, Vol.103 (5), p.694

1985

Volltextzugriff (PDF)

Characterization of group specific antibodies in primates: Studies with SIV envelope in macaques

Journal of medical primatology, 1992-02, Vol.21 (2-3), p.82-90

1992

Volltextzugriff (PDF)

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Pharmacokinetic/pharmacodynamic modeling in drug development

Modelling response time profiles in the absence of drug concentrations: definition and performance evaluation of the K-PD model

Sparse sampling for assessment of drug exposure in toxicological studies

Simultaneous Pharmacokinetic Modeling of a Drug and Two Metabolites: Application to Albendazole in Sheep

Feedback control methods for drug dosage optimisation. Concepts, classification and clinical application

Effect of adrenalectomy and aldosterone on the modulation of mineralocorticoid receptors in rat kidney

Physiologically based pharmacokinetic study on a cyclosporin derivative, SDZ IMM 125

Cytoplasmic and nuclear uptake of aldosterone in toad bladder: a mathematical modeling approach

A mathematical model of the kinetics of 5-fluorouracil and its catabolites in freshly isolated rat hepatocytes

Clinical pharmacokinetic/pharmacodynamic and physiologically based pharmacokinetic modeling in new drug development: the capecitabine experience

Isoniazid plasma and lymph kinetics after intravenous injection in dogs

A non-linear mathematical model for the in vivo determination of Kupffer cells number and rate of phagocytosis of radiocolloids in rats

The passive coping Roman Low Avoidance rat, a non-obese rat model for insulin resistance

Native but not denatured recombinant human immunodeficiency virus type 1 gp120 generates broad-spectrum neutralizing antibodies in baboons

Long-term protection of chimpanzees against high-dose HIV-1 challenge induced by immunization

Maternal Monoclonal Antibody to the V3 Loop Alters Specificity of the Response to a Human Immunodeficiency Virus Vaccine

Expression and processing of biologically active fibroblast growth factors in the yeast Saccharomyces cerevisiae

Resistance of chimpanzees immunized with recombinant gp120SF2 to challenge by HIV-1SF2

Inhibition of the offspring anti-recombinant gp120 antibody response to a human immunodeficiency virus vaccine by maternal immunization in a murine model

Importance of hypervariable regions of HIV-1 gp120 in the generation of virus neutralizing antibodies

Antibodies are produced to the variable regions of the external envelope glycoprotein of human immunodeficiency virus type 1 in chimpanzees infected with the virus and baboons immunized with a candidate recombinant vaccine

Nonaffinity purification of recombinant gp120 for use in AIDS vaccine development

HIV hyperimmune globulin or intravenous immune globulin inhibits response to an HIV vaccine

Infection by the retrovirus associated with the acquired immunodeficiency syndrome. Clinical, biological, and molecular features

Characterization of group specific antibodies in primates: Studies with SIV envelope in macaques

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