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Spontaneous de novo germline mutations in humans and mice: rates, spectra, causes and consequences

Genes & Genetic Systems, 2019/02/01, Vol.94(1), pp.13-22

Ohno, Mizuki

2019

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Toward understanding de novo germline mutations in mammals

Genes & Genetic Systems, 2019/02/01, Vol.94(1), pp.1-1

Ohno, Mizuki

2019

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Two distinct pathways of cell death triggered by oxidative damage to nuclear and mitochondrial DNAs

The EMBO journal, 2008-01, Vol.27 (2), p.421-432

2008

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Hydrogen in drinking water reduces dopaminergic neuronal loss in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease

PloS one, 2009-09, Vol.4 (9), p.e7247

2009

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Quantitative analysis of oxidized guanine, 8-oxoguanine, in mitochondrial DNA by immunofluorescence method

Methods in molecular biology (Clifton, N.J.), 2009, Vol.554, p.199

2009

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NUDT16 and ITPA play a dual protective role in maintaining chromosome stability and cell growth by eliminating dIDP/IDP and dITP/ITP from nucleotide pools in mammals

Nucleic acids research, 2010-05, Vol.38 (9), p.2891-2903

2010

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An Oxidized Purine Nucleoside Triphosphatase, MTH1, Suppresses Cell Death Caused by Oxidative Stress

The Journal of biological chemistry, 2003-09, Vol.278 (39), p.37965-37973

2003

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Mismatch repair deficient mice show susceptibility to oxidative stress-induced intestinal carcinogenesis

International journal of biological sciences, 2014-01, Vol.10 (1), p.73-79

2014

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Oxidation of mitochondrial deoxynucleotide pools by exposure to sodium nitroprusside induces cell death

DNA repair, 2008-03, Vol.7 (3), p.418-430

2008

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PSMC5, a 19S Proteasomal ATPase, Regulates Cocaine Action in the Nucleus Accumbens

PloS one, 2015-05, Vol.10 (5), p.e0126710-e0126710

2015

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Biological Significance of the Defense Mechanisms against Oxidative Damage in Nucleic Acids Caused by Reactive Oxygen Species: From Mitochondria to Nuclei

Annals of the New York Academy of Sciences, 2004-04, Vol.1011 (1), p.101-111

2004

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Growth retardation and dyslymphopoiesis accompanied by G2/M arrest in APEX2-null mice

Blood, 2004-12, Vol.104 (13), p.4097-4103

2004

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Oxidative stress accelerates intestinal tumorigenesis by enhancing 8-oxoguanine-mediated mutagenesis in MUTYH-deficient mice

Genome research, 2024-01, Vol.34 (1), p.47-56

2024

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Nature of nontargeted radiation effects observed during fractionated irradiation-induced thymic lymphomagenesis in mice

Journal of radiation research, 2013-05, Vol.54 (3), p.453-466

2013

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Oxidative-stress-driven mutagenesis in the small intestine of the gpt delta mouse induced by oral administration of potassium bromate

Mutation research, 2020-02, Vol.850-851, p.503136, Article 503136

2020

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8-oxoguanine causes spontaneous de novo germline mutations in mice

Scientific reports, 2014-04, Vol.4 (1), p.4689, Article 4689

2014

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Allele‐specific detection of nascent transcripts by fluorescence in situ hybridization reveals temporal and culture‐induced changes in Igf2 imprinting during pre‐implantation mouse development

Genes to cells : devoted to molecular & cellular mechanisms, 2001-03, Vol.6 (3), p.249-259

2001

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Mammalian Elongin A Is Not Essential for Cell Viability but Is Required for Proper Cell Cycle Progression with Limited Alteration of Gene Expression

The Journal of biological chemistry, 2003-04, Vol.278 (15), p.13585-13589

2003

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The influence of oxidized DNA on mammalian genome

Fukuoka igaku zasshi = Hukuoka acta medica, 2010-04, Vol.101 (4), p.61-68

Ohno, Mizuki

2010

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Construction and characterization of a cell line deficient in repair of mitochondrial, but not nuclear, oxidative DNA damage

Methods in molecular biology (Clifton, N.J.), 2009, Vol.554, p.251

2009

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Altered gene expression profiles and higher frequency of spontaneous DNA strand breaks in APEX2-null thymus

DNA repair, 2008-09, Vol.7 (9), p.1437-1454

2008

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Position-independent human β-globin gene expression mediated by a recombinant adeno-associated virus vector carrying the chicken β-globin insulator

Journal of human genetics, 1999-01, Vol.44 (3), p.152-162

1999

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Effects of Astaxanthin on Lipopolysaccharide-Induced Inflammation In Vitro and In Vivo

Investigative ophthalmology & visual science, 2003-06, Vol.44 (6), p.2694-2701

2003

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Aging-related changes in the sensitivity of behavioral effects of the neonicotinoid pesticide clothianidin in male mice

Toxicology letters, 2021-05, Vol.342, p.95-103

2021

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Genetic variants on chromosome 1q41 influence ocular axial length and high myopia

PLoS genetics, 2012-06, Vol.8 (6), p.e1002753-e1002753

2012

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Spontaneous de novo germline mutations in humans and mice: rates, spectra, causes and consequences

Toward understanding de novo germline mutations in mammals

Two distinct pathways of cell death triggered by oxidative damage to nuclear and mitochondrial DNAs

Hydrogen in drinking water reduces dopaminergic neuronal loss in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease

Quantitative analysis of oxidized guanine, 8-oxoguanine, in mitochondrial DNA by immunofluorescence method

NUDT16 and ITPA play a dual protective role in maintaining chromosome stability and cell growth by eliminating dIDP/IDP and dITP/ITP from nucleotide pools in mammals

An Oxidized Purine Nucleoside Triphosphatase, MTH1, Suppresses Cell Death Caused by Oxidative Stress

Mismatch repair deficient mice show susceptibility to oxidative stress-induced intestinal carcinogenesis

Oxidation of mitochondrial deoxynucleotide pools by exposure to sodium nitroprusside induces cell death

PSMC5, a 19S Proteasomal ATPase, Regulates Cocaine Action in the Nucleus Accumbens

Biological Significance of the Defense Mechanisms against Oxidative Damage in Nucleic Acids Caused by Reactive Oxygen Species: From Mitochondria to Nuclei

Growth retardation and dyslymphopoiesis accompanied by G2/M arrest in APEX2-null mice

Oxidative stress accelerates intestinal tumorigenesis by enhancing 8-oxoguanine-mediated mutagenesis in MUTYH-deficient mice

Nature of nontargeted radiation effects observed during fractionated irradiation-induced thymic lymphomagenesis in mice

Oxidative-stress-driven mutagenesis in the small intestine of the gpt delta mouse induced by oral administration of potassium bromate

8-oxoguanine causes spontaneous de novo germline mutations in mice

Allele‐specific detection of nascent transcripts by fluorescence in situ hybridization reveals temporal and culture‐induced changes in Igf2 imprinting during pre‐implantation mouse development

Mammalian Elongin A Is Not Essential for Cell Viability but Is Required for Proper Cell Cycle Progression with Limited Alteration of Gene Expression

The influence of oxidized DNA on mammalian genome

Construction and characterization of a cell line deficient in repair of mitochondrial, but not nuclear, oxidative DNA damage

Altered gene expression profiles and higher frequency of spontaneous DNA strand breaks in APEX2-null thymus

Position-independent human β-globin gene expression mediated by a recombinant adeno-associated virus vector carrying the chicken β-globin insulator

Effects of Astaxanthin on Lipopolysaccharide-Induced Inflammation In Vitro and In Vivo

Aging-related changes in the sensitivity of behavioral effects of the neonicotinoid pesticide clothianidin in male mice

Genetic variants on chromosome 1q41 influence ocular axial length and high myopia

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