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Identifying ligands at orphan GPCRs: current status using structure‐based approaches

British journal of pharmacology, 2016-10, Vol.173 (20), p.2934-2951

2016

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Crosslinking-guided geometry of a complete CXC receptor-chemokine complex and the basis of chemokine subfamily selectivity

PLoS biology, 2020-04, Vol.18 (4), p.e3000656

2020

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Metalloprotease cleavage of the N terminus of the orphan G protein-coupled receptor GPR37L1 reduces its constitutive activity

Science signaling, 2016-04, Vol.9 (423), p.ra36

2016

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Orphan receptor GPR37L1 contributes to the sexual dimorphism of central cardiovascular control

Biology of sex differences, 2018-04, Vol.9 (1), p.14-14, Article 14

2018

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Ponesimod inhibits astrocyte-mediated neuroinflammation and protects against cingulum demyelination via S1P 1 -selective modulation

The FASEB journal, 2022-02, Vol.36 (2), p.e22132

2022

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The G protein-coupled receptor N-terminus and receptor signalling: N-tering a new era

Cellular signalling, 2017-05, Vol.33, p.1-9

2017

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Receptor tyrosine kinases activate heterotrimeric G proteins via phosphorylation within the interdomain cleft of Gαi

Proceedings of the National Academy of Sciences - PNAS, 2020-11, Vol.117 (46), p.28763-28774

2020

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A long isoform of GIV/Girdin contains a PDZ-binding module that regulates localization and G-protein binding

The Journal of biological chemistry, 2021-01, Vol.296, p.100493-100493, Article 100493

2021

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Functionally Discrete Mimics of Light-activated Rhodopsin Identified through Expression of Soluble Cytoplasmic Domains

The Journal of biological chemistry, 2000-12, Vol.275 (50), p.39354-39363

2000

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The N-terminus of GPR37L1 is proteolytically processed by matrix metalloproteases

Scientific reports, 2020-11, Vol.10 (1), p.19995-19995, Article 19995

2020

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5-HT1A receptor pharmacophores to screen for off-target activity of α1-adrenoceptor antagonists

Journal of computer-aided molecular design, 2013-04, Vol.27 (4), p.305-319

2013

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The Receptor-Bound “Empty Pocket” State of the Heterotrimeric G-Protein α-Subunit Is Conformationally Dynamic

Biochemistry (Easton), 2006-10, Vol.45 (43), p.12986-12997

2006

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One-step purification of a functional, constitutively activated form of visual arrestin

Protein expression and purification, 2012-03, Vol.82 (1), p.55-60

2012

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Conformational changes associated with receptor-stimulated guanine nucleotide exchange in a heterotrimeric G-protein alpha-subunit: NMR analysis of GTPgammaS-bound states

The Journal of biological chemistry, 2006-03, Vol.281 (11), p.7635-7648

2006

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Using constitutive activity to define appropriate high-throughput screening assays for orphan g protein-coupled receptors

Methods in molecular biology (Clifton, N.J.), 2015, Vol.1272, p.91

2015

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Grafting Segments from the Extracellular Surface of CCR5 onto a Bacteriorhodopsin Transmembrane Scaffold Confers HIV-1 Coreceptor Activity

Structure (London), 2002-04, Vol.10 (4), p.515-525

2002

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Folding and assembly in rhodopsin. Effect of mutations in the sixth transmembrane helix on the conformation of the third cytoplasmic loop

The Journal of biological chemistry, 1999-07, Vol.274 (30), p.21437-21442

1999

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Preparation and Biological Activity of Amino Acid and Peptide Conjugates of Antitumor Hydroxymethylacylfulvene

Journal of medicinal chemistry, 2000-09, Vol.43 (19), p.3577-3580

2000

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Age‐dependent cardiomyopathy in mitochondrial mutator mice is attenuated by overexpression of catalase targeted to mitochondria

Aging cell, 2010-08, Vol.9 (4), p.536-544

2010

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Diverse Resistance Mechanisms to the Third-Generation ALK Inhibitor Lorlatinib in ALK-Rearranged Lung Cancer

Clinical cancer research, 2020-01, Vol.26 (1), p.242-255

2020

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Influences of circulatory factors on intervertebral disc aging phenotype

Aging (Albany, NY.), 2020-06, Vol.12 (12), p.12285-12304

2020

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7‑N‑Substituted-3-oxadiazole Quinolones with Potent Antimalarial Activity Target the Cytochrome bc 1 Complex

ACS infectious diseases, 2023-03, Vol.9 (3), p.668-691

2023

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Magnet ingestion in dogs: two cases

The Journal of the American Animal Hospital Association, 2010-05, Vol.46 (3), p.181-185

2010

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Identifying ligands at orphan GPCRs: current status using structure‐based approaches

Crosslinking-guided geometry of a complete CXC receptor-chemokine complex and the basis of chemokine subfamily selectivity

Metalloprotease cleavage of the N terminus of the orphan G protein-coupled receptor GPR37L1 reduces its constitutive activity

Orphan receptor GPR37L1 contributes to the sexual dimorphism of central cardiovascular control

Ponesimod inhibits astrocyte-mediated neuroinflammation and protects against cingulum demyelination via S1P 1 -selective modulation

The G protein-coupled receptor N-terminus and receptor signalling: N-tering a new era

Receptor tyrosine kinases activate heterotrimeric G proteins via phosphorylation within the interdomain cleft of Gαi

A long isoform of GIV/Girdin contains a PDZ-binding module that regulates localization and G-protein binding

Functionally Discrete Mimics of Light-activated Rhodopsin Identified through Expression of Soluble Cytoplasmic Domains

The N-terminus of GPR37L1 is proteolytically processed by matrix metalloproteases

5-HT1A receptor pharmacophores to screen for off-target activity of α1-adrenoceptor antagonists

The Receptor-Bound “Empty Pocket” State of the Heterotrimeric G-Protein α-Subunit Is Conformationally Dynamic

One-step purification of a functional, constitutively activated form of visual arrestin

Conformational changes associated with receptor-stimulated guanine nucleotide exchange in a heterotrimeric G-protein alpha-subunit: NMR analysis of GTPgammaS-bound states

Using constitutive activity to define appropriate high-throughput screening assays for orphan g protein-coupled receptors

Grafting Segments from the Extracellular Surface of CCR5 onto a Bacteriorhodopsin Transmembrane Scaffold Confers HIV-1 Coreceptor Activity

Folding and assembly in rhodopsin. Effect of mutations in the sixth transmembrane helix on the conformation of the third cytoplasmic loop

Preparation and Biological Activity of Amino Acid and Peptide Conjugates of Antitumor Hydroxymethylacylfulvene

Dual Plasmepsin-Targeting Antimalarial Agents Disrupt Multiple Stages of the Malaria Parasite Life Cycle

Age‐dependent cardiomyopathy in mitochondrial mutator mice is attenuated by overexpression of catalase targeted to mitochondria

Diverse Resistance Mechanisms to the Third-Generation ALK Inhibitor Lorlatinib in ALK-Rearranged Lung Cancer

Influences of circulatory factors on intervertebral disc aging phenotype

Development of Novel Models of Aggressive Variants of Castration-resistant Prostate Cancer

7‑N‑Substituted-3-oxadiazole Quinolones with Potent Antimalarial Activity Target the Cytochrome bc 1 Complex

Magnet ingestion in dogs: two cases

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