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Molecular Structure and Function of the Glycine Receptor Chloride Channel

Physiological reviews, 2004-10, Vol.84 (4), p.1051-1095

Lynch, Joseph W

2004

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Hippocampus-driven feed-forward inhibition of the prefrontal cortex mediates relapse of extinguished fear

Nature neuroscience, 2018-03, Vol.21 (3), p.384

2018

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Investigating ion channel conformational changes using voltage clamp fluorometry

Neuropharmacology, 2015-11, Vol.98, p.3-12

2015

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An Improved Ivermectin-activated Chloride Channel Receptor for Inhibiting Electrical Activity in Defined Neuronal Populations

The Journal of biological chemistry, 2010-05, Vol.285 (20), p.14890-14897

2010

Volltextzugriff (PDF)

Effects of glutamate and ivermectin on single glutamate-gated chloride channels of the parasitic nematode H. contortus

PLoS pathogens, 2017-10, Vol.13 (10), p.e1006663-e1006663

2017

Volltextzugriff (PDF)

An outline of desensitization in pentameric ligand-gated ion channel receptors

Cellular and molecular life sciences : CMLS, 2013-04, Vol.70 (7), p.1241-1253

2013

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Native glycine receptor subtypes and their physiological roles

Neuropharmacology, 2009-01, Vol.56 (1), p.303-309

Lynch, Joseph W.

2009

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Investigating the Mechanism by Which Gain-of-function Mutations to the α1 Glycine Receptor Cause Hyperekplexia

The Journal of biological chemistry, 2016-07, Vol.291 (29), p.15332-15341

2016

Volltextzugriff (PDF)

A novel anticonvulsant mechanism via inhibition of complement receptor C5ar1 in murine epilepsy models

Neurobiology of disease, 2015-04, Vol.76, p.87-97

2015

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The Prokaryote Ligand-Gated Ion Channel ELIC Captured in a Pore Blocker-Bound Conformation by the Alzheimer’s Disease Drug Memantine

Structure (London), 2014-10, Vol.22 (10), p.1399-1407

2014

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Functional reconstitution of glycinergic synapses incorporating defined glycine receptor subunit combinations

Neuropharmacology, 2015-02, Vol.89, p.391-397

2015

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Molecular pharmacology of the glycine receptor chloride channel

Current pharmaceutical design, 2007-08, Vol.13 (23), p.2350

2007

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Australian marine sponge alkaloids as a new class of glycine-gated chloride channel receptor modulator

Bioorganic & medicinal chemistry, 2013-07, Vol.21 (14), p.4420-4425

2013

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Disruption of a Structurally Important Extracellular Element in the Glycine Receptor Leads to Decreased Synaptic Integration and Signaling Resulting in Severe Startle Disease

The Journal of neuroscience, 2017-08, Vol.37 (33), p.7948-7961

2017

Volltextzugriff (PDF)

Phosphorylation of α3 Glycine Receptors Induces a Conformational Change in the Glycine-Binding Site

ACS chemical neuroscience, 2013-10, Vol.4 (10), p.1361-1370

2013

Volltextzugriff (PDF)

Sesterterpene glycinyl-lactams: a new class of glycine receptor modulator from Australian marine sponges of the genus Psammocinia

Organic & biomolecular chemistry, 2013-07, Vol.11 (28), p.4695-4701

2013

Volltextzugriff (PDF)

Ivermectin binding sites in human and invertebrate Cys-loop receptors

Trends in pharmacological sciences (Regular ed.), 2012-08, Vol.33 (8), p.432-441

2012

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Conformational Variability of the Glycine Receptor M2 Domain in Response to Activation by Different Agonists

The Journal of biological chemistry, 2007-12, Vol.282 (49), p.36057-36067

2007

Volltextzugriff (PDF)

β Subunit M2-M3 loop conformational changes are uncoupled from α1 β glycine receptor channel gating: implications for human hereditary hyperekplexia

PloS one, 2011-11, Vol.6 (11), p.e28105-e28105

2011

Volltextzugriff (PDF)

GABAA Receptor α and γ Subunits Shape Synaptic Currents via Different Mechanisms

The Journal of biological chemistry, 2014-02, Vol.289 (9), p.5399-5411

2014

Volltextzugriff (PDF)

Ircinialactams: Subunit-selective glycine receptor modulators from Australian sponges of the family Irciniidae

Bioorganic & medicinal chemistry, 2010-04, Vol.18 (8), p.2912-2919

2010

Volltextzugriff (PDF)

THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: Ion channels

British journal of pharmacology, 2019-12, Vol.176 (S1), p.S142-S228

2019

Volltextzugriff (PDF)

Potent neuroprotection after stroke afforded by a double-knot spider-venom peptide that inhibits acid-sensing ion channel 1a

Proceedings of the National Academy of Sciences - PNAS, 2017-04, Vol.114 (14), p.3750-3755

2017

Volltextzugriff (PDF)

The effects of insecticides on two splice variants of the glutamate‐gated chloride channel receptor of the major malaria vector, Anopheles gambiae

British journal of pharmacology, 2020-01, Vol.177 (1), p.175-187

2020

Volltextzugriff (PDF)

Glycine Receptor Drug Discovery

Advances in pharmacology (1990), 2017, Vol.79, p.225-253

2017

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Molecular Structure and Function of the Glycine Receptor Chloride Channel

Hippocampus-driven feed-forward inhibition of the prefrontal cortex mediates relapse of extinguished fear

Investigating ion channel conformational changes using voltage clamp fluorometry

An Improved Ivermectin-activated Chloride Channel Receptor for Inhibiting Electrical Activity in Defined Neuronal Populations

Effects of glutamate and ivermectin on single glutamate-gated chloride channels of the parasitic nematode H. contortus

An outline of desensitization in pentameric ligand-gated ion channel receptors

Native glycine receptor subtypes and their physiological roles

Investigating the Mechanism by Which Gain-of-function Mutations to the α1 Glycine Receptor Cause Hyperekplexia

A novel anticonvulsant mechanism via inhibition of complement receptor C5ar1 in murine epilepsy models

The Prokaryote Ligand-Gated Ion Channel ELIC Captured in a Pore Blocker-Bound Conformation by the Alzheimer’s Disease Drug Memantine

Functional reconstitution of glycinergic synapses incorporating defined glycine receptor subunit combinations

Molecular pharmacology of the glycine receptor chloride channel

Australian marine sponge alkaloids as a new class of glycine-gated chloride channel receptor modulator

Disruption of a Structurally Important Extracellular Element in the Glycine Receptor Leads to Decreased Synaptic Integration and Signaling Resulting in Severe Startle Disease

Phosphorylation of α3 Glycine Receptors Induces a Conformational Change in the Glycine-Binding Site

Sesterterpene glycinyl-lactams: a new class of glycine receptor modulator from Australian marine sponges of the genus Psammocinia

Ivermectin binding sites in human and invertebrate Cys-loop receptors

Conformational Variability of the Glycine Receptor M2 Domain in Response to Activation by Different Agonists

β Subunit M2-M3 loop conformational changes are uncoupled from α1 β glycine receptor channel gating: implications for human hereditary hyperekplexia

GABAA Receptor α and γ Subunits Shape Synaptic Currents via Different Mechanisms

Ircinialactams: Subunit-selective glycine receptor modulators from Australian sponges of the family Irciniidae

THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: Ion channels

Potent neuroprotection after stroke afforded by a double-knot spider-venom peptide that inhibits acid-sensing ion channel 1a

The effects of insecticides on two splice variants of the glutamate‐gated chloride channel receptor of the major malaria vector, Anopheles gambiae

Glycine Receptor Drug Discovery

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