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The transcriptional program, functional heterogeneity, and clinical targeting of mast cells

The Journal of experimental medicine, 2017-09, Vol.214 (9), p.2491-2506

2017

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Demethylating therapy increases anti-CD123 CAR T cell cytotoxicity against acute myeloid leukemia

Nature communications, 2021-11, Vol.12 (1), p.6436-20, Article 6436

2021

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Mechanisms of vitamin D3 metabolite repression of IgE-dependent mast cell activation

Journal of allergy and clinical immunology, 2014-05, Vol.133 (5), p.1356-1364.e14

2014

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The granulocyte-macrophage colony-stimulating factor receptor: linking its structure to cell signaling and its role in disease

Blood, 2009-08, Vol.114 (7), p.1289-1298

2009

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Targeting sphingosine kinase 1 induces MCL1-dependent cell death in acute myeloid leukemia

Blood, 2017-02, Vol.129 (6), p.771-782

2017

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Blocking the human common beta subunit of the GM-CSF, IL-5 and IL-3 receptors markedly reduces hyperinflammation in ARDS models

Cell death & disease, 2022-02, Vol.13 (2), p.137-137, Article 137

2022

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14-3-3ζ coordinates adipogenesis of visceral fat

Nature communications, 2015-07, Vol.6 (1), p.7671, Article 7671

2015

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The Nedd4-2/Ndfip1 axis is a negative regulator of IgE-mediated mast cell activation

Nature communications, 2016-10, Vol.7 (1), p.13198-13198, Article 13198

2016

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A dual role for the N-terminal domain of the IL-3 receptor in cell signalling

Nature communications, 2018-01, Vol.9 (1), p.386-15, Article 386

2018

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Efficacy of an Fc-modified anti-CD123 antibody (CSL362) combined with chemotherapy in xenograft models of acute myelogenous leukemia in immunodeficient mice

Haematologica (Roma), 2015-07, Vol.100 (7), p.914

2015

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Dual Mechanism of Interleukin-3 Receptor Blockade by an Anti-Cancer Antibody

Cell reports (Cambridge), 2014-07, Vol.8 (2), p.410-419

2014

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A Negative Regulatory Mechanism Involving 14-3-3ζ Limits Signaling Downstream of ROCK to Regulate Tissue Stiffness in Epidermal Homeostasis

Developmental cell, 2015-12, Vol.35 (6), p.759-774

2015

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Cytokine receptor activation at the cell surface

Current opinion in structural biology, 2012-06, Vol.22 (3), p.350-359

2012

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High yield production of a soluble human interleukin-3 variant from E. coli with wild-type bioactivity and improved radiolabeling properties

PloS one, 2013-08, Vol.8 (8), p.e74376-e74376

2013

Volltextzugriff (PDF)

Cutting Edge: Basophils Are Transiently Recruited into the Draining Lymph Nodes during Helminth Infection via IL-3, but Infection-Induced Th2 Immunity Can Develop without Basophil Lymph Node Recruitment or IL-3

The Journal of immunology (1950), 2010-02, Vol.184 (3), p.1143-1147

2010

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Jak2V617F driven myeloproliferative neoplasm occurs independently of interleukin-3 receptor beta common signaling

Haematologica (Roma), 2016-03, Vol.101 (3), p.e77

2016

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14-3-3ε and ζ regulate neurogenesis and differentiation of neuronal progenitor cells in the developing brain

The Journal of neuroscience, 2014-09, Vol.34 (36), p.12168-12181

2014

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Immune insufficiency during GVHD is due to defective antigen presentation within dendritic cell subsets

Blood, 2012-06, Vol.119 (24), p.5918-5930

2012

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Interleukin-3 greatly expands non-adherent endothelial forming cells with pro-angiogenic properties

Stem cell research, 2015-05, Vol.14 (3), p.380-395

2015

Volltextzugriff (PDF)

Monoclonal Antibody-Mediated Targeting of CD123, IL-3 Receptor α Chain, Eliminates Human Acute Myeloid Leukemic Stem Cells

Cell stem cell, 2009-07, Vol.5 (1), p.31-42

2009

Volltextzugriff (PDF)

14-3-3:Shc Scaffolds Integrate Phosphoserine and Phosphotyrosine Signaling to Regulate Phosphatidylinositol 3-Kinase Activation and Cell Survival

The Journal of biological chemistry, 2009-05, Vol.284 (18), p.12080-12090

2009

Volltextzugriff (PDF)

Dual inhibition of airway inflammation and fibrosis by common β cytokine receptor blockade

Journal of allergy and clinical immunology, 2024-03, Vol.153 (3), p.672-683.e6

2024

Volltextzugriff (PDF)

Targeting human CALR‐mutated MPN progenitors with a neoepitope‐directed monoclonal antibody

EMBO reports, 2022-04, Vol.23 (4), p.e52904-n/a

2022

Volltextzugriff (PDF)

The βc receptor family – Structural insights and their functional implications

Cytokine (Philadelphia, Pa.), 2015-08, Vol.74 (2), p.247-258

2015

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The transcriptional program, functional heterogeneity, and clinical targeting of mast cells

Demethylating therapy increases anti-CD123 CAR T cell cytotoxicity against acute myeloid leukemia

Mechanisms of vitamin D3 metabolite repression of IgE-dependent mast cell activation

The granulocyte-macrophage colony-stimulating factor receptor: linking its structure to cell signaling and its role in disease

Targeting sphingosine kinase 1 induces MCL1-dependent cell death in acute myeloid leukemia

Blocking the human common beta subunit of the GM-CSF, IL-5 and IL-3 receptors markedly reduces hyperinflammation in ARDS models

14-3-3ζ coordinates adipogenesis of visceral fat

The Nedd4-2/Ndfip1 axis is a negative regulator of IgE-mediated mast cell activation

A dual role for the N-terminal domain of the IL-3 receptor in cell signalling

Efficacy of an Fc-modified anti-CD123 antibody (CSL362) combined with chemotherapy in xenograft models of acute myelogenous leukemia in immunodeficient mice

Dual Mechanism of Interleukin-3 Receptor Blockade by an Anti-Cancer Antibody

A Negative Regulatory Mechanism Involving 14-3-3ζ Limits Signaling Downstream of ROCK to Regulate Tissue Stiffness in Epidermal Homeostasis

Cytokine receptor activation at the cell surface

TLR7 gain-of-function genetic variation causes human lupus

High yield production of a soluble human interleukin-3 variant from E. coli with wild-type bioactivity and improved radiolabeling properties

Cutting Edge: Basophils Are Transiently Recruited into the Draining Lymph Nodes during Helminth Infection via IL-3, but Infection-Induced Th2 Immunity Can Develop without Basophil Lymph Node Recruitment or IL-3

Jak2V617F driven myeloproliferative neoplasm occurs independently of interleukin-3 receptor beta common signaling

14-3-3ε and ζ regulate neurogenesis and differentiation of neuronal progenitor cells in the developing brain

Immune insufficiency during GVHD is due to defective antigen presentation within dendritic cell subsets

Interleukin-3 greatly expands non-adherent endothelial forming cells with pro-angiogenic properties

Monoclonal Antibody-Mediated Targeting of CD123, IL-3 Receptor α Chain, Eliminates Human Acute Myeloid Leukemic Stem Cells

14-3-3:Shc Scaffolds Integrate Phosphoserine and Phosphotyrosine Signaling to Regulate Phosphatidylinositol 3-Kinase Activation and Cell Survival

Dual inhibition of airway inflammation and fibrosis by common β cytokine receptor blockade

Targeting human CALR‐mutated MPN progenitors with a neoepitope‐directed monoclonal antibody

The βc receptor family – Structural insights and their functional implications

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