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GPCR expression in tissues and cells: Are the optimal receptors being used as drug targets?

British journal of pharmacology, 2012-03, Vol.165 (6), p.1613-1616

2012

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G-protein-coupled receptor-signaling components in membrane raft and caveolae microdomains

Handbook of experimental pharmacology, 2008 (186), p.167

2008

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Cyclic AMP/PKA-promoted apoptosis: insights from studies of S49 lymphoma cells

Hormone and metabolic research, 2014-11, Vol.46 (12), p.854-862

2014

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The Pro-apoptotic Protein Bim Is a Convergence Point for cAMP/Protein Kinase A- and Glucocorticoid-promoted Apoptosis of Lymphoid Cells

The Journal of biological chemistry, 2004-05, Vol.279 (20), p.20858-20865

2004

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Protein kinase C isozymes and the regulation of diverse cell responses

American journal of physiology. Lung cellular and molecular physiology, 2000-09, Vol.279 (3), p.429-L438

2000

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Forskolin as a tool for examining adenylyl cyclase expression, regulation, and G protein signaling

Cellular and molecular neurobiology, 2003-06, Vol.23 (3), p.305-314

2003

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Inhibition of Apoptosis in Normal and Transformed Intestinal Epithelial Cells by cAMP through Induction of Inhibitor of Apoptosis Protein (IAP)-2

Proceedings of the National Academy of Sciences - PNAS, 2003-07, Vol.100 (15), p.8921-8926

2003

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Genetic variations and polymorphisms of G protein-coupled receptors: functional and therapeutic implications

Annual review of pharmacology and toxicology, 2001-01, Vol.41 (1), p.593-624

2001

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Do studies in caveolin‐knockouts teach us about physiology and pharmacology or instead, the ways mice compensate for ‘lost proteins’?

British journal of pharmacology, 2007-02, Vol.150 (3), p.251-254

2007

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Receptor Number and Caveolar Co-localization Determine Receptor Coupling Efficiency to Adenylyl Cyclase

The Journal of biological chemistry, 2001-11, Vol.276 (45), p.42063-42069

2001

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The Cellular Thermal Shift Assay: A Novel Biophysical Assay for In Situ Drug Target Engagement and Mechanistic Biomarker Studies

Annual review of pharmacology and toxicology, 2016-01, Vol.56 (1), p.141-161

2016

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Compartmentation of G-protein-coupled receptors and their signalling components in lipid rafts and caveolae

Biochemical Society transactions, 2005-11, Vol.33 (Pt 5), p.1131-1134

2005

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Cellular Release of and Response to ATP as Key Determinants of the Set-Point of Signal Transduction Pathways

The Journal of biological chemistry, 2000-04, Vol.275 (16), p.11735-11739

2000

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Stoichiometry and compartmentation in G protein-coupled receptor signaling: implications for therapeutic interventions involving G(s)

The Journal of pharmacology and experimental therapeutics, 2000-08, Vol.294 (2), p.407

2000

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Increased Expression of Adenylylcyclase Type VI Proportionately Increases β -adrenergic Receptor-Stimulated Production of cAMP in Neonatal Rat Cardiac Myocytes

Proceedings of the National Academy of Sciences - PNAS, 1998-02, Vol.95 (3), p.1038-1043

1998

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Aβ deposition is associated with increases in soluble and phosphorylated tau that precede a positive Tau PET in Alzheimer's disease

Science advances, 2020-04, Vol.6 (16), p.eaaz2387-eaaz2387

2020

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Application of Microphysiological Systems to Enhance Safety Assessment in Drug Discovery

Annual review of pharmacology and toxicology, 2018-01, Vol.58 (1), p.65-82

2018

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Role of Cell Death in Toxicology: Does It Matter How Cells Die?

Annual review of pharmacology and toxicology, 2019-01, Vol.59 (1), p.1-14

Orrenius, Sten

2019

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Pharmacoepigenetics and Toxicoepigenetics: Novel Mechanistic Insights and Therapeutic Opportunities

Annual review of pharmacology and toxicology, 2018-01, Vol.58 (1), p.161-185

2018

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Beta-adrenergic receptors and receptor signaling in heart failure

Annual review of pharmacology and toxicology, 1999-01, Vol.39 (1), p.343-360

1999

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Retrovirally mediated transfer of a G protein-coupled receptor kinase (GRK) dominant-negative mutant enhances endogenous calcitonin receptor signaling in Chinese hamster ovary cells. GRK inhibition enhances expression of receptors and receptor mRNA

The Journal of biological chemistry, 2000-09, Vol.275 (38), p.29433-29440

2000

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An Arginine/Glutamine Difference at the Juxtaposition of Transmembrane Domain 6 and the Third Extracellular Loop Contributes to the Markedly Different Nucleotide Selectivities of Human and Canine P2Y11 Receptors

Molecular pharmacology, 2001-12, Vol.60 (6), p.1375-1382

2001

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Selective enhancement of beta-adrenergic receptor signaling by overexpression of adenylyl cyclase type 6: colocalization of receptor and adenylyl cyclase in caveolae of cardiac myocytes

Molecular pharmacology, 2000-05, Vol.57 (5), p.1075-1079

2000

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Protein kinase C alpha mediates phospholipase D activation by nucleotides and phorbol ester in Madin-Darby canine kidney cells. Stimulation of phospholipase D is independent of activation of polyphosphoinositide-specific phospholipase C and phospholipase A2

The Journal of biological chemistry, 1994-04, Vol.269 (14), p.10511-10516

1994

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Quantification of signalling components and amplification in the beta-adrenergic-receptor-adenylate cyclase pathway in isolated adult rat ventricular myocytes

Biochemical journal, 1995-10, Vol.311 ( Pt 1) (1), p.75-80

1995

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GPCR expression in tissues and cells: Are the optimal receptors being used as drug targets?

G-protein-coupled receptor-signaling components in membrane raft and caveolae microdomains

Cyclic AMP/PKA-promoted apoptosis: insights from studies of S49 lymphoma cells

The Pro-apoptotic Protein Bim Is a Convergence Point for cAMP/Protein Kinase A- and Glucocorticoid-promoted Apoptosis of Lymphoid Cells

Protein kinase C isozymes and the regulation of diverse cell responses

Forskolin as a tool for examining adenylyl cyclase expression, regulation, and G protein signaling

Inhibition of Apoptosis in Normal and Transformed Intestinal Epithelial Cells by cAMP through Induction of Inhibitor of Apoptosis Protein (IAP)-2

Genetic variations and polymorphisms of G protein-coupled receptors: functional and therapeutic implications

Do studies in caveolin‐knockouts teach us about physiology and pharmacology or instead, the ways mice compensate for ‘lost proteins’?

Receptor Number and Caveolar Co-localization Determine Receptor Coupling Efficiency to Adenylyl Cyclase

The Cellular Thermal Shift Assay: A Novel Biophysical Assay for In Situ Drug Target Engagement and Mechanistic Biomarker Studies

Compartmentation of G-protein-coupled receptors and their signalling components in lipid rafts and caveolae

Cellular Release of and Response to ATP as Key Determinants of the Set-Point of Signal Transduction Pathways

Stoichiometry and compartmentation in G protein-coupled receptor signaling: implications for therapeutic interventions involving G(s)

Increased Expression of Adenylylcyclase Type VI Proportionately Increases β -adrenergic Receptor-Stimulated Production of cAMP in Neonatal Rat Cardiac Myocytes

Aβ deposition is associated with increases in soluble and phosphorylated tau that precede a positive Tau PET in Alzheimer's disease

Application of Microphysiological Systems to Enhance Safety Assessment in Drug Discovery

Role of Cell Death in Toxicology: Does It Matter How Cells Die?

Pharmacoepigenetics and Toxicoepigenetics: Novel Mechanistic Insights and Therapeutic Opportunities

Beta-adrenergic receptors and receptor signaling in heart failure

Retrovirally mediated transfer of a G protein-coupled receptor kinase (GRK) dominant-negative mutant enhances endogenous calcitonin receptor signaling in Chinese hamster ovary cells. GRK inhibition enhances expression of receptors and receptor mRNA

An Arginine/Glutamine Difference at the Juxtaposition of Transmembrane Domain 6 and the Third Extracellular Loop Contributes to the Markedly Different Nucleotide Selectivities of Human and Canine P2Y11 Receptors

Selective enhancement of beta-adrenergic receptor signaling by overexpression of adenylyl cyclase type 6: colocalization of receptor and adenylyl cyclase in caveolae of cardiac myocytes

Protein kinase C alpha mediates phospholipase D activation by nucleotides and phorbol ester in Madin-Darby canine kidney cells. Stimulation of phospholipase D is independent of activation of polyphosphoinositide-specific phospholipase C and phospholipase A2

Quantification of signalling components and amplification in the beta-adrenergic-receptor-adenylate cyclase pathway in isolated adult rat ventricular myocytes

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