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Tau: From research to clinical development

Alzheimer's & dementia, 2016-10, Vol.12 (10), p.1033-1039

2016

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Design and synthesis of a novel series of histamine H3 receptor antagonists through a scaffold hopping strategy

Bioorganic & medicinal chemistry, 2015-02, Vol.23 (3), p.429-438

2015

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Discovery of a potent, selective, and orally bioavailable histamine H3 receptor antagonist SAR110068 for the treatment of sleep–wake disorders

Bioorganic & medicinal chemistry letters, 2013-11, Vol.23 (22), p.6141-6145

2013

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Discovery of aryl ureas and aryl amides as potent and selective histamine H3 receptor antagonists for the treatment of obesity (Part I)

Bioorganic & medicinal chemistry letters, 2013-06, Vol.23 (11), p.3416-3420

2013

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Discovery of aryl ureas and aryl amides as potent and selective histamine H3 receptor antagonists for the treatment of obesity (Part II)

Bioorganic & medicinal chemistry letters, 2013-06, Vol.23 (11), p.3421-3426

2013

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Synthesis and Structure-Activity Relationship of the Isoindolinyl Benzisoxazolpiperidines as Potent, Selective, and Orally Active Human Dopamine D4 Receptor Antagonists

Chembiochem : a European journal of chemical biology, 2002-10, Vol.3 (10), p.999-1009

2002

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Synthesis, characterization, and biological assessment of the four stereoisomers of the H(3) receptor antagonist 5-fluoro-2-methyl-N-[2-methyl-4-(2-methyl[1,3']bipyrrolidinyl-1'-yl)phenyl]benzamide

Bioorganic & medicinal chemistry letters, 2013-07, Vol.23 (14), p.4044-4047

2013

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Identification and profiling of 3,5-dimethyl-isoxazole-4-carboxylic acid [2-methyl-4-((2S,3'S)-2-methyl-[1,3']bipyrrolidinyl-1'-yl)phenyl] amide as histamine H(3) receptor antagonist for the treatment of depression

Bioorganic & medicinal chemistry letters, 2013-12, Vol.23 (23), p.6269-6273

2013

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MyD88 and IL-1R signaling drive antibacterial immunity and osteoclast-driven bone loss during Staphylococcus aureus osteomyelitis

PLoS pathogens, 2019-04, Vol.15 (4), p.e1007744-e1007744

2019

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The Impact of Broadly Relevant Novel Discoveries on Student Project Ownership in a Traditional Lab Course Turned CURE

CBE life sciences education, 2019-12, Vol.18 (4), p.ar57-ar57

2019

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Novel multipurpose pod-intravaginal ring for the prevention of HIV, HSV, and unintended pregnancy: Pharmacokinetic evaluation in a macaque model

PloS one, 2017-10, Vol.12 (10), p.e0185946

2017

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Repurposing the Nonsteroidal Anti-inflammatory Drug Diflunisal as an Osteoprotective, Antivirulence Therapy for Staphylococcus aureus Osteomyelitis

Antimicrobial agents and chemotherapy, 2016-09, Vol.60 (9), p.5322-5330

2016

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Vasculogenic mimicry in small cell lung cancer

Nature communications, 2016-11, Vol.7 (1), p.13322-13322, Article 13322

2016

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The emerging roles of ribosomal histidyl hydroxylases in cell biology, physiology and disease

Cellular and molecular life sciences : CMLS, 2018-11, Vol.75 (22), p.4093-4105

2018

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MHCII-independent CD4+ T cells protect injured CNS neurons via IL-4

The Journal of clinical investigation, 2015-02, Vol.125 (2), p.699-714

2015

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Nanoparticulate carbon black in cigarette smoke induces DNA cleavage and Th17-mediated emphysema

eLife, 2015-10, Vol.4, p.e09623-e09623

2015

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Mechanisms of Vaccine-Induced Protective Immunity against Coxiella burnetii Infection in BALB/c Mice

The Journal of immunology (1950), 2007-12, Vol.179 (12), p.8372-8380

2007

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Implications of leading crop production practices on environmental quality and human health

Journal of environmental management, 2015-03, Vol.151, p.267-279

2015

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Identification and Characterization of an Immunodominant 28-Kilodalton Coxiella burnetii Outer Membrane Protein Specific to Isolates Associated with Acute Disease

Infection and Immunity, 2005-03, Vol.73 (3), p.1561-1567

2005

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Identification and Cloning of Immunodominant Antigens of Coxiella burnetii

Infection and Immunity, 2004-02, Vol.72 (2), p.844-852

2004

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Laboratory Maintenance of Coxiella burnetii

Current protocols in microbiology (Online), 2009-11, Vol.15 (1), p.6C.1.1-6C.1.16

2009

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Invasion and metastasis of a mammary tumor involves TGF‐β signaling

International journal of cancer, 2001-01, Vol.91 (1), p.76-82

2001

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Cardiac ion channel effects of tolterodine

The Journal of pharmacology and experimental therapeutics, 2004-03, Vol.308 (3), p.935

2004

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DENSE: efficient and prior knowledge-driven discovery of phenotype-associated protein functional modules

BMC systems biology, 2011-10, Vol.5 (183), p.172-172, Article 172

2011

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Tau: From research to clinical development

Design and synthesis of a novel series of histamine H3 receptor antagonists through a scaffold hopping strategy

Discovery of a potent, selective, and orally bioavailable histamine H3 receptor antagonist SAR110068 for the treatment of sleep–wake disorders

Discovery of aryl ureas and aryl amides as potent and selective histamine H3 receptor antagonists for the treatment of obesity (Part I)

Discovery of aryl ureas and aryl amides as potent and selective histamine H3 receptor antagonists for the treatment of obesity (Part II)

Synthesis and Structure-Activity Relationship of the Isoindolinyl Benzisoxazolpiperidines as Potent, Selective, and Orally Active Human Dopamine D4 Receptor Antagonists

Synthesis, characterization, and biological assessment of the four stereoisomers of the H(3) receptor antagonist 5-fluoro-2-methyl-N-[2-methyl-4-(2-methyl[1,3']bipyrrolidinyl-1'-yl)phenyl]benzamide

Identification and profiling of 3,5-dimethyl-isoxazole-4-carboxylic acid [2-methyl-4-((2S,3'S)-2-methyl-[1,3']bipyrrolidinyl-1'-yl)phenyl] amide as histamine H(3) receptor antagonist for the treatment of depression

MyD88 and IL-1R signaling drive antibacterial immunity and osteoclast-driven bone loss during Staphylococcus aureus osteomyelitis

The Impact of Broadly Relevant Novel Discoveries on Student Project Ownership in a Traditional Lab Course Turned CURE

Novel multipurpose pod-intravaginal ring for the prevention of HIV, HSV, and unintended pregnancy: Pharmacokinetic evaluation in a macaque model

Repurposing the Nonsteroidal Anti-inflammatory Drug Diflunisal as an Osteoprotective, Antivirulence Therapy for Staphylococcus aureus Osteomyelitis

Vasculogenic mimicry in small cell lung cancer

The emerging roles of ribosomal histidyl hydroxylases in cell biology, physiology and disease

MHCII-independent CD4+ T cells protect injured CNS neurons via IL-4

Nanoparticulate carbon black in cigarette smoke induces DNA cleavage and Th17-mediated emphysema

Expert consensus document: Mind the gaps—advancing research into short-term and long-term neuropsychological outcomes of youth sports-related concussions

Mechanisms of Vaccine-Induced Protective Immunity against Coxiella burnetii Infection in BALB/c Mice

Implications of leading crop production practices on environmental quality and human health

Identification and Characterization of an Immunodominant 28-Kilodalton Coxiella burnetii Outer Membrane Protein Specific to Isolates Associated with Acute Disease

Identification and Cloning of Immunodominant Antigens of Coxiella burnetii

Laboratory Maintenance of Coxiella burnetii

Invasion and metastasis of a mammary tumor involves TGF‐β signaling

Cardiac ion channel effects of tolterodine

DENSE: efficient and prior knowledge-driven discovery of phenotype-associated protein functional modules

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