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CD133, Selectively Targeting the Root of Cancer

Toxins, 2016-05, Vol.8 (6), p.165

2016

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Development of a Deimmunized Bispecific Immunotoxin dDT2219 against B-Cell Malignancies

Toxins, 2018-01, Vol.10 (1), p.32

2018

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Bispecific Targeting of EGFR and Urokinase Receptor (uPAR) Using Ligand-Targeted Toxins in Solid Tumors

Biomolecules (Basel, Switzerland), 2020-06, Vol.10 (6), p.956

2020

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Evaluation of 18-F-fluoro-2-deoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) as a staging and monitoring tool for dogs with stage-2 splenic hemangiosarcoma - A pilot study

PloS one, 2017-02, Vol.12 (2), p.e0172651-e0172651

2017

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Mutagenic Deimmunization of Diphtheria Toxin for Use in Biologic Drug Development

Toxins, 2015-10, Vol.7 (10), p.4067-4082

2015

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Natural killer cells unleashed: Checkpoint receptor blockade and BiKE/TriKE utilization in NK-mediated anti-tumor immunotherapy

Seminars in immunology, 2017-06, Vol.31, p.64-75

2017

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Hemangiosarcoma and its cancer stem cell subpopulation are effectively killed by a toxin targeted through epidermal growth factor and urokinase receptors

International journal of cancer, 2013-10, Vol.133 (8), p.1936-1944

2013

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IL15 Trispecific Killer Engagers (TriKE) Make Natural Killer Cells Specific to CD33+ Targets While Also Inducing Persistence, In Vivo Expansion, and Enhanced Function

Clinical cancer research, 2016-07, Vol.22 (14), p.3440-3450

2016

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Eradication of Heterogeneous Tumors by T Cells Targeted with Combination Bispecific Chemically Self-assembled Nanorings

Molecular cancer therapeutics, 2023-03, Vol.22 (3), p.371-380

2023

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A bispecific EpCAM/CD133-targeted toxin is effective against carcinoma

Targeted oncology, 2014-09, Vol.9 (3), p.239-249

2014

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A Novel Reduced Immunogenicity Bispecific Targeted Toxin Simultaneously Recognizing Human Epidermal Growth Factor and Interleukin-4 Receptors in a Mouse Model of Metastatic Breast Carcinoma

Clinical cancer research, 2009-10, Vol.15 (19), p.6137-6147

2009

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A Bispecific Recombinant Immunotoxin, DT2219, Targeting Human CD19 and CD22 Receptors in a Mouse Xenograft Model of B-Cell Leukemia/Lymphoma

Clinical cancer research, 2005-05, Vol.11 (10), p.3879-3888

2005

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Increasing Anticarcinoma Activity of an Anti-erbB2 Recombinant Immunotoxin by the Addition of an Anti-EpCAM sFv

Clinical cancer research, 2007-05, Vol.13 (10), p.3058-3067

2007

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A Bispecific Recombinant Cytotoxin (DTEGF13) Targeting Human Interleukin-13 and Epidermal Growth Factor Receptors in a Mouse Xenograft Model of Prostate Cancer

Clinical cancer research, 2007-11, Vol.13 (21), p.6486-6493

2007

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Program death-1 signaling and regulatory T cells collaborate to resist the function of adoptively transferred cytotoxic T lymphocytes in advanced acute myeloid leukemia

Blood, 2010-10, Vol.116 (14), p.2484-2493

2010

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Delineation of target expression profiles in CD34+/CD38− and CD34+/CD38+ stem and progenitor cells in AML and CML

Blood advances, 2020-10, Vol.4 (20), p.5118-5132

2020

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Targeting CD133 in an in vivo ovarian cancer model reduces ovarian cancer progression

Gynecologic oncology, 2013-09, Vol.130 (3), p.579-587

2013

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Diphtheria toxin-based targeted toxin therapy for brain tumors

Journal of neuro-oncology, 2013-09, Vol.114 (2), p.155-164

2013

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Safe and Effective Sarcoma Therapy through Bispecific Targeting of EGFR and uPAR

Molecular cancer therapeutics, 2017-05, Vol.16 (5), p.956-965

2017

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Bispecific targeting of EGFR and uPAR in a mouse model of head and neck squamous cell carcinoma

Oral oncology, 2012-12, Vol.48 (12), p.1202-1207

2012

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Depletion of endogenous tumor-associated regulatory T cells improves the efficacy of adoptive cytotoxic T-cell immunotherapy in murine acute myeloid leukemia

Blood, 2009-10, Vol.114 (18), p.3793-3802

2009

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Targeting tumor-initiating cancer cells with dCD133KDEL shows impressive tumor reductions in a xenotransplant model of human head and neck cancer

Molecular cancer therapeutics, 2011-10, Vol.10 (10), p.1829-1838

2011

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Genetic alteration of a bispecific ligand-directed toxin targeting human CD19 and CD22 receptors resulting in improved efficacy against systemic B cell malignancy

Leukemia research, 2009-09, Vol.33 (9), p.1233-1242

2009

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Bioengineering a unique deimmunized bispecific targeted toxin that simultaneously recognizes human CD22 and CD19 receptors in a mouse model of B-cell metastases

Molecular cancer therapeutics, 2010-06, Vol.9 (6), p.1872-1883

2010

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CD133, Selectively Targeting the Root of Cancer

Development of a Deimmunized Bispecific Immunotoxin dDT2219 against B-Cell Malignancies

Bispecific Targeting of EGFR and Urokinase Receptor (uPAR) Using Ligand-Targeted Toxins in Solid Tumors

Evaluation of 18-F-fluoro-2-deoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) as a staging and monitoring tool for dogs with stage-2 splenic hemangiosarcoma - A pilot study

Toxicity Profile of eBAT, a Bispecific Ligand-Targeted Toxin Directed to EGFR and uPAR, in Mice and a Clinical Dog Model

Mutagenic Deimmunization of Diphtheria Toxin for Use in Biologic Drug Development

Natural killer cells unleashed: Checkpoint receptor blockade and BiKE/TriKE utilization in NK-mediated anti-tumor immunotherapy

Hemangiosarcoma and its cancer stem cell subpopulation are effectively killed by a toxin targeted through epidermal growth factor and urokinase receptors

IL15 Trispecific Killer Engagers (TriKE) Make Natural Killer Cells Specific to CD33+ Targets While Also Inducing Persistence, In Vivo Expansion, and Enhanced Function

Eradication of Heterogeneous Tumors by T Cells Targeted with Combination Bispecific Chemically Self-assembled Nanorings

A bispecific EpCAM/CD133-targeted toxin is effective against carcinoma

A Novel Reduced Immunogenicity Bispecific Targeted Toxin Simultaneously Recognizing Human Epidermal Growth Factor and Interleukin-4 Receptors in a Mouse Model of Metastatic Breast Carcinoma

A Bispecific Recombinant Immunotoxin, DT2219, Targeting Human CD19 and CD22 Receptors in a Mouse Xenograft Model of B-Cell Leukemia/Lymphoma

Increasing Anticarcinoma Activity of an Anti-erbB2 Recombinant Immunotoxin by the Addition of an Anti-EpCAM sFv

A Bispecific Recombinant Cytotoxin (DTEGF13) Targeting Human Interleukin-13 and Epidermal Growth Factor Receptors in a Mouse Xenograft Model of Prostate Cancer

Program death-1 signaling and regulatory T cells collaborate to resist the function of adoptively transferred cytotoxic T lymphocytes in advanced acute myeloid leukemia

Delineation of target expression profiles in CD34+/CD38− and CD34+/CD38+ stem and progenitor cells in AML and CML

Targeting CD133 in an in vivo ovarian cancer model reduces ovarian cancer progression

Diphtheria toxin-based targeted toxin therapy for brain tumors

Safe and Effective Sarcoma Therapy through Bispecific Targeting of EGFR and uPAR

Bispecific targeting of EGFR and uPAR in a mouse model of head and neck squamous cell carcinoma

Depletion of endogenous tumor-associated regulatory T cells improves the efficacy of adoptive cytotoxic T-cell immunotherapy in murine acute myeloid leukemia

Targeting tumor-initiating cancer cells with dCD133KDEL shows impressive tumor reductions in a xenotransplant model of human head and neck cancer

Genetic alteration of a bispecific ligand-directed toxin targeting human CD19 and CD22 receptors resulting in improved efficacy against systemic B cell malignancy

Bioengineering a unique deimmunized bispecific targeted toxin that simultaneously recognizes human CD22 and CD19 receptors in a mouse model of B-cell metastases

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