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Human-Immune-System (HIS) humanized mouse model (DRAGA: HLA-A2.HLA-DR4.Rag1KO.IL-2RγcKO.NOD) for COVID-19

Human vaccines & immunotherapeutics, 2022-11, Vol.18 (5), p.2048622-2048622

2022

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Expression of HLA class II molecules in humanized NOD.Rag1KO.IL2RgcKO mice is critical for development and function of human T and B cells

PloS one, 2011-05, Vol.6 (5), p.e19826

2011

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Myeloid-derived suppressor cells prevent type 1 diabetes in murine models

The Journal of immunology (1950), 2010-11, Vol.185 (10), p.5828-5834

2010

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Humanized DRAGA mice immunized with Plasmodium falciparum sporozoites and chloroquine elicit protective pre-erythrocytic immunity

Malaria journal, 2018-03, Vol.17 (1), p.114-114, Article 114

2018

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Increased membrane cholesterol in lymphocytes diverts T-cells toward an inflammatory response

PloS one, 2012-06, Vol.7 (6), p.e38733

2012

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TFH cells accumulate in mucosal tissues of humanized-DRAG mice and are highly permissive to HIV-1

Scientific reports, 2015-06, Vol.5 (1), p.10443-10443, Article 10443

2015

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HIV-1 infected humanized DRAGA mice develop HIV-specific antibodies despite lack of canonical germinal centers in secondary lymphoid tissues

Frontiers in immunology, 2022-11, Vol.13, p.1047277-1047277

2022

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The humanized DRAGA mouse (HLA-A2. HLA-DR4. RAG1 KO. IL-2R g c KO. NOD) establishes inducible and transmissible models for influenza type A infections

Human vaccines & immunotherapeutics, 2020-09, Vol.16 (9), p.2222-2237

2020

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Immune evasion by malaria parasites: a challenge for vaccine development

Current opinion in immunology, 2009-06, Vol.21 (3), p.321-330

2009

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Generation and testing anti-influenza human monoclonal antibodies in a new humanized mouse model (DRAGA: HLA-A2. HLA-DR4. Rag1 KO. IL-2Rγc KO. NOD)

Human vaccines & immunotherapeutics, 2018-02, Vol.14 (2), p.345-360

2018

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Differential effect of HLA class-I versus class-II transgenes on human T and B cell reconstitution and function in NRG mice

Scientific reports, 2016-06, Vol.6 (1), p.28093-28093, Article 28093

2016

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HLA Class II (DR0401) Molecules Induce Foxp3+ Regulatory T Cell Suppression of B Cells in Plasmodium yoelii Strain 17XNL Malaria

Infection and Immunity, 2014-01, Vol.82 (1), p.286-297

2014

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Humanized HLA-DR4 mice fed with the protozoan pathogen of oysters Perkinsus marinus (Dermo) do not develop noticeable pathology but elicit systemic immunity

PloS one, 2014-01, Vol.9 (1), p.e87435-e87435

2014

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Improvements and Limitations of Humanized Mouse Models for HIV Research: NIH/NIAID "Meet the Experts" 2015 Workshop Summary

AIDS research and human retroviruses, 2016-02, Vol.32 (2), p.109

2016

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Humanized HLA-DR4.RagKO.IL2RγcKO.NOD (DRAG) mice sustain the complex vertebrate life cycle of Plasmodium falciparum malaria

Malaria journal, 2014-09, Vol.13 (1), p.386-386, Article 386

2014

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HLA-DR0401 expression in the NOD mice prevents the development of autoimmune diabetes by multiple alterations in the T-cell compartment

Cellular immunology, 2015-11, Vol.298 (1-2), p.54-65

2015

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Differential effect of CD4+ Foxp3+ T-regulatory cells on the B and T helper cell responses to influenza virus vaccination

Vaccine, 2010-10, Vol.28 (45), p.7319-7330

2010

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Down-regulation of diabetogenic CD4 + T cells by a soluble dimeric peptide-MHC class II chimera

Nature immunology, 2002-04, Vol.3 (4), p.383-391

2002

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Long-term silencing of autoimmune diabetes and improved life expectancy by a soluble pHLA-DR4 chimera in a newly-humanized NOD/DR4/B7 mouse

Human vaccines & immunotherapeutics, 2014-03, Vol.10 (3), p.693-699

2014

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Antigen presentation by dendritic cells after immunization with DNA encoding a major histocompatibility complex class II-restricted viral epitope

The Journal of experimental medicine, 1997-11, Vol.186 (9), p.1481-1486

1997

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Reversal of type 1 diabetes by a new MHC II‐peptide chimera: “Single‐epitope‐mediated suppression” to stabilize a polyclonal autoimmune T‐cell process

European journal of immunology, 2010-08, Vol.40 (8), p.2277-2288

2010

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E-cadherin missense mutations, associated with hereditary diffuse gastric cancer (HDGC) syndrome, display distinct invasive behaviors and genetic interactions with the Wnt and Notch pathways in Drosophila epithelia

Human molecular genetics, 2006-05, Vol.15 (10), p.1704-1712

2006

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Analysis of lipid rafts in T cells

Molecular immunology, 2004-06, Vol.41 (4), p.399-409

2004

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Down-regulation of autoreactive T-cells by HMG CoA reductase inhibitors

Clinical Immunology, 2006-04, Vol.119 (1), p.1-12

2006

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Insights into the pathogenesis of type 1 diabetes: a hint for novel immunospecific therapies

Current molecular medicine, 2001-07, Vol.1 (3), p.357

2001

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Human-Immune-System (HIS) humanized mouse model (DRAGA: HLA-A2.HLA-DR4.Rag1KO.IL-2RγcKO.NOD) for COVID-19

Expression of HLA class II molecules in humanized NOD.Rag1KO.IL2RgcKO mice is critical for development and function of human T and B cells

Myeloid-derived suppressor cells prevent type 1 diabetes in murine models

Humanized DRAGA mice immunized with Plasmodium falciparum sporozoites and chloroquine elicit protective pre-erythrocytic immunity

Increased membrane cholesterol in lymphocytes diverts T-cells toward an inflammatory response

TFH cells accumulate in mucosal tissues of humanized-DRAG mice and are highly permissive to HIV-1

HIV-1 infected humanized DRAGA mice develop HIV-specific antibodies despite lack of canonical germinal centers in secondary lymphoid tissues

The humanized DRAGA mouse (HLA-A2. HLA-DR4. RAG1 KO. IL-2R g c KO. NOD) establishes inducible and transmissible models for influenza type A infections

Immune evasion by malaria parasites: a challenge for vaccine development

Generation and testing anti-influenza human monoclonal antibodies in a new humanized mouse model (DRAGA: HLA-A2. HLA-DR4. Rag1 KO. IL-2Rγc KO. NOD)

Differential effect of HLA class-I versus class-II transgenes on human T and B cell reconstitution and function in NRG mice

HLA Class II (DR0401) Molecules Induce Foxp3+ Regulatory T Cell Suppression of B Cells in Plasmodium yoelii Strain 17XNL Malaria

Humanized HLA-DR4 mice fed with the protozoan pathogen of oysters Perkinsus marinus (Dermo) do not develop noticeable pathology but elicit systemic immunity

Improvements and Limitations of Humanized Mouse Models for HIV Research: NIH/NIAID "Meet the Experts" 2015 Workshop Summary

Humanized HLA-DR4.RagKO.IL2RγcKO.NOD (DRAG) mice sustain the complex vertebrate life cycle of Plasmodium falciparum malaria

HLA-DR0401 expression in the NOD mice prevents the development of autoimmune diabetes by multiple alterations in the T-cell compartment

Differential effect of CD4+ Foxp3+ T-regulatory cells on the B and T helper cell responses to influenza virus vaccination

Down-regulation of diabetogenic CD4 + T cells by a soluble dimeric peptide-MHC class II chimera

Long-term silencing of autoimmune diabetes and improved life expectancy by a soluble pHLA-DR4 chimera in a newly-humanized NOD/DR4/B7 mouse

Antigen presentation by dendritic cells after immunization with DNA encoding a major histocompatibility complex class II-restricted viral epitope

Reversal of type 1 diabetes by a new MHC II‐peptide chimera: “Single‐epitope‐mediated suppression” to stabilize a polyclonal autoimmune T‐cell process

E-cadherin missense mutations, associated with hereditary diffuse gastric cancer (HDGC) syndrome, display distinct invasive behaviors and genetic interactions with the Wnt and Notch pathways in Drosophila epithelia

Analysis of lipid rafts in T cells

Down-regulation of autoreactive T-cells by HMG CoA reductase inhibitors

Insights into the pathogenesis of type 1 diabetes: a hint for novel immunospecific therapies

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