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Discovery of Novel, Induced-Pocket Binding Oxazolidinones as Potent, Selective, and Orally Bioavailable Tankyrase Inhibitors

Journal of medicinal chemistry, 2013-06, Vol.56 (11), p.4320-4342

2013

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Application of a Parallel Synthetic Strategy in the Discovery of Biaryl Acyl Sulfonamides as Efficient and Selective NaV1.7 Inhibitors

Journal of medicinal chemistry, 2016-09, Vol.59 (17), p.7818-7839

2016

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Inhibition of Inactive States of Tetrodotoxin-Sensitive Sodium Channels Reduces Spontaneous Firing of C-Fiber Nociceptors and Produces Analgesia in Formalin and Complete Freund's Adjuvant Models of Pain

PloS one, 2015-09, Vol.10 (9), p.e0138140

2015

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The Crystal Structure of BRAF in Complex with an Organoruthenium Inhibitor Reveals a Mechanism for Inhibition of an Active Form of BRAF Kinase

Biochemistry (Easton), 2009-06, Vol.48 (23), p.5187-5198

2009

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The Discovery and Hit-to-Lead Optimization of Tricyclic Sulfonamides as Potent and Efficacious Potentiators of Glycine Receptors

Journal of medicinal chemistry, 2017-02, Vol.60 (3), p.1105-1125

2017

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Organometallic Compounds with Biological Activity: A Very Selective and Highly Potent Cellular Inhibitor for Glycogen Synthase Kinase 3

Chembiochem : a European journal of chemical biology, 2006-09, Vol.7 (9), p.1443-1450

2006

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Identification of a Potent, State-Dependent Inhibitor of Nav1.7 with Oral Efficacy in the Formalin Model of Persistent Pain

Journal of medicinal chemistry, 2011-07, Vol.54 (13), p.4427-4445

2011

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Switching on a Signaling Pathway with an Organoruthenium Complex

Angewandte Chemie (International ed.), 2005-03, Vol.44 (13), p.1984-1987

2005

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Sulfonamides as Selective Na V 1.7 Inhibitors: Optimizing Potency and Pharmacokinetics While Mitigating Metabolic Liabilities

Journal of medicinal chemistry, 2017-07, Vol.60 (14), p.5969-5989

2017

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The discovery of benzoxazine sulfonamide inhibitors of Na V 1.7: Tools that bridge efficacy and target engagement

Bioorganic & medicinal chemistry letters, 2017-08, Vol.27 (15), p.3477-3485

2017

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2-Phenylamino-6-cyano-1H-benzimidazole-based isoform selective casein kinase 1 gamma (CK1γ) inhibitors

Bioorganic & medicinal chemistry letters, 2012-09, Vol.22 (17), p.5392-5395

2012

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The discovery of aminopyrazines as novel, potent Na(v)1.7 antagonists: hit-to-lead identification and SAR

Bioorganic & medicinal chemistry letters, 2012-03, Vol.22 (5), p.2033-2042

2012

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Specificity of induction of cancer protective enzymes by analogues of tert-butyl-4-hydroxyanisole (BHA)

Biochemical pharmacology, 1985-11, Vol.34 (21), p.3909-3914

1985

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Discovery of Novel, Induced-Pocket Binding Oxazolidinones as Potent, Selective, and Orally Bioavailable Tankyrase Inhibitors

Application of a Parallel Synthetic Strategy in the Discovery of Biaryl Acyl Sulfonamides as Efficient and Selective NaV1.7 Inhibitors

Inhibition of Inactive States of Tetrodotoxin-Sensitive Sodium Channels Reduces Spontaneous Firing of C-Fiber Nociceptors and Produces Analgesia in Formalin and Complete Freund's Adjuvant Models of Pain

Electrophilic properties of itaconate and derivatives regulate the IκBζ-ATF3 inflammatory axis

The Crystal Structure of BRAF in Complex with an Organoruthenium Inhibitor Reveals a Mechanism for Inhibition of an Active Form of BRAF Kinase

The Discovery and Hit-to-Lead Optimization of Tricyclic Sulfonamides as Potent and Efficacious Potentiators of Glycine Receptors

Organometallic Compounds with Biological Activity: A Very Selective and Highly Potent Cellular Inhibitor for Glycogen Synthase Kinase 3

Identification of a Potent, State-Dependent Inhibitor of Nav1.7 with Oral Efficacy in the Formalin Model of Persistent Pain

Switching on a Signaling Pathway with an Organoruthenium Complex

Sulfonamides as Selective Na V 1.7 Inhibitors: Optimizing Potency and Pharmacokinetics While Mitigating Metabolic Liabilities

The discovery of benzoxazine sulfonamide inhibitors of Na V 1.7: Tools that bridge efficacy and target engagement

2-Phenylamino-6-cyano-1H-benzimidazole-based isoform selective casein kinase 1 gamma (CK1γ) inhibitors

The discovery of aminopyrazines as novel, potent Na(v)1.7 antagonists: hit-to-lead identification and SAR

Specificity of induction of cancer protective enzymes by analogues of tert-butyl-4-hydroxyanisole (BHA)

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