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PBPK models for the prediction of in vivo performance of oral dosage forms

European journal of pharmaceutical sciences, 2014-06, Vol.57 (SI), p.300-321

2014

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Predicting the impact of physiological and biochemical processes on oral drug bioavailability

Advanced drug delivery reviews, 2001-10, Vol.50, p.S41-S67

2001

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In Silico Modeling for the Nonlinear Absorption Kinetics of UK-343,664: A P-gp and CYP3A4 Substrate

Molecular pharmaceutics, 2012-03, Vol.9 (3), p.492-504

2012

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Simulations of the Nonlinear Dose Dependence for Substrates of Influx and Efflux Transporters in the Human Intestine

The AAPS journal, 2009-06, Vol.11 (2), p.353-363

2009

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Application of Mechanistic Ocular Absorption Modeling and Simulation to Understand the Impact of Formulation Properties on Ophthalmic Bioavailability in Rabbits: a Case Study Using Dexamethasone Suspension

The AAPS journal, 2019-07, Vol.21 (4), p.65, Article 65

2019

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Human Ontogeny of Drug Transporters: Review and Recommendations of the Pediatric Transporter Working Group

Clinical pharmacology and therapeutics, 2015-09, Vol.98 (3), p.266-287

2015

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Modeling of absorption

Methods in molecular biology (Clifton, N.J.), 2012, Vol.929, p.313

2012

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Characterization of the anticonvulsant properties of ganaxolone (CCD 1042; 3alpha-hydroxy-3beta-methyl-5alpha-pregnan-20-one), a selective, high-affinity, steroid modulator of the gamma-aminobutyric acid(A) receptor

The Journal of pharmacology and experimental therapeutics, 1997-03, Vol.280 (3), p.1284

1997

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Thyroxine analogs. 23. Quantitative structure-activity correlation studies of in vivo and in vitro thyromimetic activities

Journal of medicinal chemistry, 1977-07, Vol.20 (7), p.863-880

1977

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Synthesis and in Vitro Activity of 3β-Substituted-3α-hydroxypregnan-20-ones: Allosteric Modulators of the GABAA Receptor

Journal of medicinal chemistry, 1997-01, Vol.40 (1), p.61-72

1997

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Anticonvulsant profile of the progesterone metabolite 5α-pregnan-3α-ol-20-one

European journal of pharmacology, 1989-07, Vol.166 (2), p.325-329

1989

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Proton-driven dipeptide uptake in primary cultured rabbit conjunctival epithelial cells

Investigative ophthalmology & visual science, 1998-11, Vol.39 (12), p.2365-2373

1998

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Differential Responses of Expressed Recombinant Human γ‐Aminobutyric AcidA Receptors to Neurosteroids

Journal of neurochemistry, 1991-11, Vol.57 (5), p.1818-1821

1991

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In vivo and in vitro hyperbaric studies in mice suggest novel sites of action for ethanol

Psychopharmacologia, 1999-02, Vol.141 (4), p.339-350

1999

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In vitro and in vivo activity of 16,17-dehydro-epipregnanolones : 17,20-bond torsional energy analysis and D-ring conformation

Pharmaceutical research, 1996-10, Vol.13 (10), p.1488-1494

1996

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Identification and characterization of a pregnane steroid recognition site that is functionally coupled to an expressed GABAA receptor

Neurochemical research, 1991-03, Vol.16 (3), p.347-356

1991

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Low level hyperbaric antagonism of diazepam's locomotor depressant and anticonvulsant properties in mice

The Journal of pharmacology and experimental therapeutics, 1996-02, Vol.276 (2), p.667

1996

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[2] Computer modeling of combining site structure of anti-hapten monoclonal antibodies

Methods in Enzymology, 1991, Vol.203, p.21-45

1991

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Three-dimensional structure of fibrolase, the fibrinolytic enzyme from southern copperhead venom, modeled from the X-ray structure of adamalysin II and atrolysin C

AAPS PharmSci, 2001-01, Vol.3 (2), p.E16-90

2001

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Global distribution of earthworm diversity

Science (American Association for the Advancement of Science), 2019-10, Vol.366 (6464), p.480-485

2019

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Attenuation of the Activity of the cAMP-specific Phosphodiesterase PDE4A5 by Interaction with the Immunophilin XAP2

The Journal of biological chemistry, 2003-08, Vol.278 (35), p.33351-33363

2003

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Characterization of aryl hydrocarbon receptor interacting protein (AIP) mutations in familial isolated pituitary adenoma families

Human mutation, 2010-08, Vol.31 (8), p.950-960

2010

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The RACK1 Signaling Scaffold Protein Selectively Interacts with the cAMP-specific Phosphodiesterase PDE4D5 Isoform

The Journal of biological chemistry, 1999-05, Vol.274 (21), p.14909-14917

1999

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Characterisation of carbon paste electrodes for real-time amperometric monitoring of brain tissue oxygen

Journal of neuroscience methods, 2011-02, Vol.195 (2), p.135-142

2011

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PBPK models for the prediction of in vivo performance of oral dosage forms

Predicting the impact of physiological and biochemical processes on oral drug bioavailability

In Silico Modeling for the Nonlinear Absorption Kinetics of UK-343,664: A P-gp and CYP3A4 Substrate

Simulations of the Nonlinear Dose Dependence for Substrates of Influx and Efflux Transporters in the Human Intestine

In vivo methods for drug absorption – Comparative physiologies, model selection, correlations with in vitro methods (IVIVC), and applications for formulation/API/excipient characterization including food effects

Application of Mechanistic Ocular Absorption Modeling and Simulation to Understand the Impact of Formulation Properties on Ophthalmic Bioavailability in Rabbits: a Case Study Using Dexamethasone Suspension

Human Ontogeny of Drug Transporters: Review and Recommendations of the Pediatric Transporter Working Group

Modeling of absorption

Characterization of the anticonvulsant properties of ganaxolone (CCD 1042; 3alpha-hydroxy-3beta-methyl-5alpha-pregnan-20-one), a selective, high-affinity, steroid modulator of the gamma-aminobutyric acid(A) receptor

Thyroxine analogs. 23. Quantitative structure-activity correlation studies of in vivo and in vitro thyromimetic activities

Synthesis and in Vitro Activity of 3β-Substituted-3α-hydroxypregnan-20-ones: Allosteric Modulators of the GABAA Receptor

Anticonvulsant profile of the progesterone metabolite 5α-pregnan-3α-ol-20-one

Proton-driven dipeptide uptake in primary cultured rabbit conjunctival epithelial cells

Differential Responses of Expressed Recombinant Human γ‐Aminobutyric AcidA Receptors to Neurosteroids

In vivo and in vitro hyperbaric studies in mice suggest novel sites of action for ethanol

In vitro and in vivo activity of 16,17-dehydro-epipregnanolones : 17,20-bond torsional energy analysis and D-ring conformation

Identification and characterization of a pregnane steroid recognition site that is functionally coupled to an expressed GABAA receptor

Low level hyperbaric antagonism of diazepam's locomotor depressant and anticonvulsant properties in mice

[2] Computer modeling of combining site structure of anti-hapten monoclonal antibodies

Three-dimensional structure of fibrolase, the fibrinolytic enzyme from southern copperhead venom, modeled from the X-ray structure of adamalysin II and atrolysin C

Global distribution of earthworm diversity

Attenuation of the Activity of the cAMP-specific Phosphodiesterase PDE4A5 by Interaction with the Immunophilin XAP2

Characterization of aryl hydrocarbon receptor interacting protein (AIP) mutations in familial isolated pituitary adenoma families

The RACK1 Signaling Scaffold Protein Selectively Interacts with the cAMP-specific Phosphodiesterase PDE4D5 Isoform

Characterisation of carbon paste electrodes for real-time amperometric monitoring of brain tissue oxygen

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