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What Role Does CFTR Play in Development, Differentiation, Regeneration and Cancer?

International journal of molecular sciences, 2020-04, Vol.21 (9), p.3133

2020

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Rescuing mutant CFTR: a multi-task approach to a better outcome in treating cystic fibrosis

Current pharmaceutical design, 2013, Vol.19 (19), p.3497

2013

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A genetic screening strategy identifies novel regulators of the proteostasis network

PLoS genetics, 2011-12, Vol.7 (12), p.e1002438-e1002438

2011

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Molecular targeting of CFTR as a therapeutic approach to cystic fibrosis

Trends in pharmacological sciences (Regular ed.), 2007-07, Vol.28 (7), p.334-341

2007

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Most F508del-CFTR Is Targeted to Degradation at an Early Folding Checkpoint and Independently of Calnexin

Molecular and Cellular Biology, 2005-06, Vol.25 (12), p.5242-5252

2005

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Targeting CFTR: how to treat cystic fibrosis by CFTR-repairing therapies

Current drug targets, 2011-05, Vol.12 (5), p.683

Amaral, Margarida D

2011

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A central role of the endoplasmic reticulum in the cell emerges from its functional contact sites with multiple organelles

Cellular and molecular life sciences : CMLS, 2020-12, Vol.77 (23), p.4729-4745

2020

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New pharmacological approaches for cystic fibrosis: promises, progress, pitfalls

Pharmacology & therapeutics (Oxford), 2015-01, Vol.145, p.19-34

2015

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Neuronal reprograming of protein homeostasis by calcium-dependent regulation of the heat shock response

PLoS genetics, 2013-08, Vol.9 (8), p.e1003711-e1003711

2013

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Neuronal signaling modulates protein homeostasis in Caenorhabditis elegans post-synaptic muscle cells

Genes & development, 2007-11, Vol.21 (22), p.3006-3016

2007

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CFTR and chaperones: processing and degradation

Journal of molecular neuroscience, 2004-01, Vol.23 (1-2), p.41-48

Amaral, Margarida D

2004

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Contribution of Casein Kinase 2 and Spleen Tyrosine Kinase to CFTR Trafficking and Protein Kinase A-Induced Activity

Molecular and Cellular Biology, 2011-11, Vol.31 (22), p.4392-4404

2011

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Antagonistic Regulation of Cystic Fibrosis Transmembrane Conductance Regulator Cell Surface Expression by Protein Kinases WNK4 and Spleen Tyrosine Kinase

Molecular and Cellular Biology, 2011-10, Vol.31 (19), p.4076-4086

2011

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Revertant Mutants G550E and 4RK Rescue Cystic Fibrosis Mutants in the First Nucleotide-Binding domain of CFTR by Different Mechanisms

Proceedings of the National Academy of Sciences - PNAS, 2006-11, Vol.103 (47), p.17891-17896

2006

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CFTR mutations altering CFTR fragmentation

Biochemical journal, 2013-01, Vol.449 (1), p.295-305

2013

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Regulation of the Epithelial Na+ Channel by the Protein Kinase CK2

The Journal of biological chemistry, 2008-05, Vol.283 (19), p.13225-13232

2008

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The effect of premature termination codon mutations on CFTR mRNA abundance in human nasal epithelium and intestinal organoids: a basis for read‐through therapies in cystic fibrosis

Human mutation, 2019-03, Vol.40 (3), p.326-334, Article humu.23692

2019

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Chimeric Constructs Endow the Human CFTR Cl⁻ Channel with the Gating Behavior of Murine CFTR

Proceedings of the National Academy of Sciences - PNAS, 2007-10, Vol.104 (41), p.16365-16370

2007

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The third dimension: new developments in cell culture models for colorectal research

Cellular and molecular life sciences : CMLS, 2016-11, Vol.73 (21), p.3971-3989

2016

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Partial rescue of F508del‐cystic fibrosis transmembrane conductance regulator channel gating with modest improvement of protein processing, but not stability, by a dual‐acting small molecule

British journal of pharmacology, 2018-04, Vol.175 (7), p.1017-1038

2018

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Impact of the cystic fibrosis mutation F508del-CFTR on renal cyst formation and growth

American journal of physiology. Renal physiology, 2012-10, Vol.303 (8), p.F1176-F1186

2012

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Revertant mutants modify, but do not rescue, the gating defect of the cystic fibrosis mutant G551D‐CFTR

The Journal of physiology, 2014-05, Vol.592 (9), p.1931-1947

2014

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Therapy through chaperones: Sense or antisense? Cystic fibrosis as a model disease

Journal of inherited metabolic disease, 2006-04, Vol.29 (2-3), p.477-487

Amaral, Margarida D.

2006

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AMPK controls epithelial Na+ channels through Nedd4-2 and causes an epithelial phenotype when mutated

Pflügers Archiv, 2009-08, Vol.458 (4), p.713-721

2009

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HGF Stimulation of Rac1 Signaling Enhances Pharmacological Correction of the Most Prevalent Cystic Fibrosis Mutant F508del-CFTR

ACS chemical biology, 2013-02, Vol.8 (2), p.432-442

2013

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What Role Does CFTR Play in Development, Differentiation, Regeneration and Cancer?

Rescuing mutant CFTR: a multi-task approach to a better outcome in treating cystic fibrosis

A genetic screening strategy identifies novel regulators of the proteostasis network

Molecular targeting of CFTR as a therapeutic approach to cystic fibrosis

Most F508del-CFTR Is Targeted to Degradation at an Early Folding Checkpoint and Independently of Calnexin

Targeting CFTR: how to treat cystic fibrosis by CFTR-repairing therapies

A central role of the endoplasmic reticulum in the cell emerges from its functional contact sites with multiple organelles

New pharmacological approaches for cystic fibrosis: promises, progress, pitfalls

Neuronal reprograming of protein homeostasis by calcium-dependent regulation of the heat shock response

Neuronal signaling modulates protein homeostasis in Caenorhabditis elegans post-synaptic muscle cells

CFTR and chaperones: processing and degradation

Contribution of Casein Kinase 2 and Spleen Tyrosine Kinase to CFTR Trafficking and Protein Kinase A-Induced Activity

Antagonistic Regulation of Cystic Fibrosis Transmembrane Conductance Regulator Cell Surface Expression by Protein Kinases WNK4 and Spleen Tyrosine Kinase

Revertant Mutants G550E and 4RK Rescue Cystic Fibrosis Mutants in the First Nucleotide-Binding domain of CFTR by Different Mechanisms

CFTR mutations altering CFTR fragmentation

Regulation of the Epithelial Na+ Channel by the Protein Kinase CK2

The effect of premature termination codon mutations on CFTR mRNA abundance in human nasal epithelium and intestinal organoids: a basis for read‐through therapies in cystic fibrosis

Chimeric Constructs Endow the Human CFTR Cl⁻ Channel with the Gating Behavior of Murine CFTR

The third dimension: new developments in cell culture models for colorectal research

Partial rescue of F508del‐cystic fibrosis transmembrane conductance regulator channel gating with modest improvement of protein processing, but not stability, by a dual‐acting small molecule

Impact of the cystic fibrosis mutation F508del-CFTR on renal cyst formation and growth

Revertant mutants modify, but do not rescue, the gating defect of the cystic fibrosis mutant G551D‐CFTR

Therapy through chaperones: Sense or antisense? Cystic fibrosis as a model disease

AMPK controls epithelial Na+ channels through Nedd4-2 and causes an epithelial phenotype when mutated

HGF Stimulation of Rac1 Signaling Enhances Pharmacological Correction of the Most Prevalent Cystic Fibrosis Mutant F508del-CFTR

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