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Safety and activity of the TGFβ receptor I kinase inhibitor galunisertib plus the anti-PD-L1 antibody durvalumab in metastatic pancreatic cancer
Journal for immunotherapy of cancer, 2021-03, Vol.9 (3), p.e002068
2021
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Ethnic differences in the population pharmacokinetics and pharmacodynamics of warfarin
Journal of pharmacokinetics and pharmacodynamics, 2010-02, Vol.37 (1), p.3-24
2010
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Galunisertib plus gemcitabine vs. gemcitabine for first-line treatment of patients with unresectable pancreatic cancer
British journal of cancer, 2018-11, Vol.119 (10), p.1208-1214
2018
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Randomized Phase III Study of FOLFOX Alone or With Pegilodecakin as Second-Line Therapy in Patients With Metastatic Pancreatic Cancer That Progressed After Gemcitabine (SEQUOIA)
Journal of clinical oncology, 2021-04, Vol.39 (10), p.1108-1118
2021
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First-in-human dose study of the novel transforming growth factor-β receptor I kinase inhibitor LY2157299 monohydrate in patients with advanced cancer and glioma
Clinical cancer research, 2015-02, Vol.21 (3), p.553-560
2015
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Phase 1 study of galunisertib, a TGF-beta receptor I kinase inhibitor, in Japanese patients with advanced solid tumors
Cancer chemotherapy and pharmacology, 2015-12, Vol.76 (6), p.1143-1152
2015
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A phase 1 study of anti-TGFβ receptor type-II monoclonal antibody LY3022859 in patients with advanced solid tumors
Cancer chemotherapy and pharmacology, 2017-04, Vol.79 (4), p.673-680
2017
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Pharmacokinetic, pharmacodynamic and biomarker evaluation of transforming growth factor-β receptor I kinase inhibitor, galunisertib, in phase 1 study in patients with advanced cancer
Investigational new drugs, 2015-04, Vol.33 (2), p.357-370
2015
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Population pharmacokinetics and exposure–overall survival analysis of the transforming growth factor-β inhibitor galunisertib in patients with pancreatic cancer
Cancer chemotherapy and pharmacology, 2019-11, Vol.84 (5), p.1003-1015
2019
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Defining a therapeutic window for the novel TGF‐β inhibitor LY2157299 monohydrate based on a pharmacokinetic/pharmacodynamic model
British journal of clinical pharmacology, 2014-05, Vol.77 (5), p.796-807
2014
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Cardiac Safety of TGF-β Receptor I Kinase Inhibitor LY2157299 Monohydrate in Cancer Patients in a First-in-Human Dose Study
Cardiovascular toxicology, 2015-10, Vol.15 (4), p.309-323
2015
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Assessment of In Vivo Clinical Product Performance of a Weak Basic Drug by Integration of In Vitro Dissolution Tests and Physiologically Based Absorption Modeling
The AAPS journal, 2015-11, Vol.17 (6), p.1395-1406
2015
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Biomarker and Histopathology Evaluation of Patients with Recurrent Glioblastoma Treated with Galunisertib, Lomustine, or the Combination of Galunisertib and Lomustine
International journal of molecular sciences, 2017-05, Vol.18 (5), p.995
2017
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Pharmacokinetic modelling of interleukin‐1 receptor antagonist in plasma and cerebrospinal fluid of patients following subarachnoid haemorrhage
British journal of clinical pharmacology, 2008-03, Vol.65 (3), p.317-325
2008
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Desipramine, substrate for CYP2D6 activity: population pharmacokinetic model and design elements of drug–drug interaction trials
British journal of clinical pharmacology, 2010-10, Vol.70 (4), p.523-536
2010
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