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Interspecies evaluation of a physiologically based pharmacokinetic model to predict the biodistribution dynamics of dendritic nanoparticles

PloS one, 2023-05, Vol.18 (5), p.e0285798-e0285798

2023

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Astrocyte-mediated metaplasticity in the hippocampus: Help or hindrance?

Neuroscience, 2015-11, Vol.309, p.113-124

Jones, O.D

2015

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PHRMA CPCDC initiative on predictive models of human pharmacokinetics, part 5: Prediction of plasma concentration–time profiles in human by using the physiologically‐based pharmacokinetic modeling approach

Journal of pharmaceutical sciences, 2011-10, Vol.100 (10), p.4127-4157

2011

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Quantitative Evaluation of Dendritic Nanoparticles in Mice: Biodistribution Dynamics and Downstream Tumor Efficacy Outcomes

Molecular pharmaceutics, 2022-01, Vol.19 (1), p.172-187

2022

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PhRMA CPCDC initiative on predictive models of human pharmacokinetics, part 4: Prediction of plasma concentration–time profiles in human from in vivo preclinical data by using the Wajima approach

Journal of pharmaceutical sciences, 2011-10, Vol.100 (10), p.4111-4126

2011

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Improving the Accuracy of Predicted Human Pharmacokinetics: Lessons Learned from the AstraZeneca Drug Pipeline Over Two Decades

Trends in pharmacological sciences (Regular ed.), 2020-06, Vol.41 (6), p.390-408

2020

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Comparative analysis of pattern, management and outcome of pre‐ versus postnatally diagnosed major congenital heart disease: a population‐based study

Ultrasound in obstetrics & gynecology, 2001-05, Vol.17 (5), p.380-385

2001

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Pharmacokinetic/Pharmacodynamic Analysis of Savolitinib plus Osimertinib in an EGFR Mutation-Positive, MET-Amplified Non-Small Cell Lung Cancer Model

Molecular cancer therapeutics, 2023-05, Vol.22 (5), p.679-690

2023

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A PKPD Case Study: Achieving Clinically Relevant Exposures of AZD5991 in Oncology Mouse Models

The AAPS journal, 2023-06, Vol.25 (4), p.66-66, Article 66

2023

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Mutation of a type II keratin gene (K6a) in pachyonychia congenita

Nature genetics, 1995-07, Vol.10 (3), p.363-365

1995

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The MET Inhibitor AZD6094 (Savolitinib, HMPL-504) Induces Regression in Papillary Renal Cell Carcinoma Patient-Derived Xenograft Models

Clinical cancer research, 2015-06, Vol.21 (12), p.2811-2819

2015

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Developing PreDICT – a fully integrated data platform for preclinical in vivo data: learning from experience

Drug discovery today, 2017-10, Vol.22 (10), p.1539-1546

2017

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Model-based drug discovery: implementation and impact

Drug discovery today, 2013-08, Vol.18 (15-16), p.764-775

2013

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AZD3514: a small molecule that modulates androgen receptor signaling and function in vitro and in vivo

Molecular cancer therapeutics, 2013-09, Vol.12 (9), p.1715-1727

2013

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Mammalian chromodomain proteins: their role in genome organisation and expression

BioEssays, 2000-02, Vol.22 (2), p.124-137

2000

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Discovery of AZD3514, a small-molecule androgen receptor downregulator for treatment of advanced prostate cancer

Bioorganic & medicinal chemistry letters, 2013-04, Vol.23 (7), p.1945-1948

2013

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Characterization and Chromosomal Localization of Human Hair-Specific Keratin Genes and Comparative Expression During the Hair Growth Cycle

Journal of investigative dermatology, 1998-02, Vol.110 (2), p.158-164

1998

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Birthmark due to cutaneous mosaicism for keratin 10 mutation

The Lancet (British edition), 1995-03, Vol.345 (8949), p.596-596

1995

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Further Considerations Towards an Effective and Efficient Oncology Drug Discovery DMPK Strategy

Current drug metabolism, 2020-01, Vol.21 (2), p.145

2020

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Endowment Effects in Chimpanzees

Current biology, 2007-10, Vol.17 (19), p.1704-1707

2007

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Focused Cardiac Ultrasound in the Emergent Setting: A Consensus Statement of the American Society of Echocardiography and American College of Emergency Physicians

Journal of the American Society of Echocardiography, 2010-12, Vol.23 (12), p.1225-1230

2010

Volltextzugriff (PDF)

Validating Psychiatric Diagnoses

The American journal of psychiatry, 1996-01, Vol.153 (1), p.141-141

1996

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A Dashboard for Problem-Solving Patient Access and Physician Staffing Issues

Family practice management, 2023-11, Vol.30 (6), p.37

2023

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Percutaneous balloon pulmonary valvuloplasty

British Heart Journal, 1985-05, Vol.53 (5), p.520-524

1985

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Interspecies evaluation of a physiologically based pharmacokinetic model to predict the biodistribution dynamics of dendritic nanoparticles

Astrocyte-mediated metaplasticity in the hippocampus: Help or hindrance?

PHRMA CPCDC initiative on predictive models of human pharmacokinetics, part 5: Prediction of plasma concentration–time profiles in human by using the physiologically‐based pharmacokinetic modeling approach

Discovery of N‑(4-{[5-Fluoro-7-(2-methoxyethoxy)quinazolin-4-yl]amino}phenyl)-2-[4-(propan-2-yl)‑1H‑1,2,3-triazol-1-yl]acetamide (AZD3229), a Potent Pan-KIT Mutant Inhibitor for the Treatment of Gastrointestinal Stromal Tumors

Quantitative Evaluation of Dendritic Nanoparticles in Mice: Biodistribution Dynamics and Downstream Tumor Efficacy Outcomes

PhRMA CPCDC initiative on predictive models of human pharmacokinetics, part 4: Prediction of plasma concentration–time profiles in human from in vivo preclinical data by using the Wajima approach

Improving the Accuracy of Predicted Human Pharmacokinetics: Lessons Learned from the AstraZeneca Drug Pipeline Over Two Decades

Comparative analysis of pattern, management and outcome of pre‐ versus postnatally diagnosed major congenital heart disease: a population‐based study

Pharmacokinetic/Pharmacodynamic Analysis of Savolitinib plus Osimertinib in an EGFR Mutation-Positive, MET-Amplified Non-Small Cell Lung Cancer Model

A PKPD Case Study: Achieving Clinically Relevant Exposures of AZD5991 in Oncology Mouse Models

Mutation of a type II keratin gene (K6a) in pachyonychia congenita

The MET Inhibitor AZD6094 (Savolitinib, HMPL-504) Induces Regression in Papillary Renal Cell Carcinoma Patient-Derived Xenograft Models

Developing PreDICT – a fully integrated data platform for preclinical in vivo data: learning from experience

Model-based drug discovery: implementation and impact

AZD3514: a small molecule that modulates androgen receptor signaling and function in vitro and in vivo

Mammalian chromodomain proteins: their role in genome organisation and expression

Discovery of AZD3514, a small-molecule androgen receptor downregulator for treatment of advanced prostate cancer

Characterization and Chromosomal Localization of Human Hair-Specific Keratin Genes and Comparative Expression During the Hair Growth Cycle

Birthmark due to cutaneous mosaicism for keratin 10 mutation

Further Considerations Towards an Effective and Efficient Oncology Drug Discovery DMPK Strategy

Endowment Effects in Chimpanzees

Focused Cardiac Ultrasound in the Emergent Setting: A Consensus Statement of the American Society of Echocardiography and American College of Emergency Physicians

Validating Psychiatric Diagnoses

A Dashboard for Problem-Solving Patient Access and Physician Staffing Issues

Percutaneous balloon pulmonary valvuloplasty

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