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Understanding the glucoregulatory mechanisms of metformin in type 2 diabetes mellitus

Nature reviews. Endocrinology, 2019-10, Vol.15 (10), p.569

2019

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Metformin: From Mechanisms of Action to Therapies

Cell metabolism, 2014-12, Vol.20 (6), p.953-966

2014

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Cellular and molecular mechanisms of metformin: an overview

Clinical science (1979), 2012-03, Vol.122 (6), p.253

2012

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AMPK Activation Reduces Hepatic Lipid Content by Increasing Fat Oxidation In Vivo

International journal of molecular sciences, 2018-09, Vol.19 (9), p.2826

2018

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Obesity Impairs Skeletal Muscle Regeneration Through Inhibition of AMPK

Diabetes (New York, N.Y.), 2016-01, Vol.65 (1), p.188-200

2016

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Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state

The Journal of clinical investigation, 2010-07, Vol.120 (7), p.2355-2369

2010

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AMPKα1 Regulates Macrophage Skewing at the Time of Resolution of Inflammation during Skeletal Muscle Regeneration

Cell metabolism, 2013-08, Vol.18 (2), p.251-264

2013

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Anti-Inflammatory Effects of Metformin Irrespective of Diabetes Status

Circulation research, 2016-08, Vol.119 (5), p.652-665

2016

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AMPK Re-Activation Suppresses Hepatic Steatosis but its Downregulation Does Not Promote Fatty Liver Development

EBioMedicine, 2018-02, Vol.28 (C), p.194-209

2018

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Enhanced Muscle Insulin Sensitivity After Contraction/Exercise Is Mediated by AMPK

Diabetes (New York, N.Y.), 2017-03, Vol.66 (3), p.598-612

2017

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AMP-Activated Protein Kinase―Deficient Mice Are Resistant to the Metabolic Effects of Resveratrol

Diabetes (New York, N.Y.), 2010-03, Vol.59 (3), p.554-563

2010

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Aβ42 oligomers trigger synaptic loss through CAMKK2-AMPK-dependent effectors coordinating mitochondrial fission and mitophagy

Nature communications, 2022-08, Vol.13 (1), p.4444-4444, Article 4444

2022

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Activation of AMPKα2 in adipocytes is essential for nicotine-induced insulin resistance in vivo

Nature medicine, 2015-04, Vol.21 (4), p.373-382

2015

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SIKs control osteocyte responses to parathyroid hormone

Nature communications, 2016-10, Vol.7 (1), p.13176-13176, Article 13176

2016

Volltextzugriff (PDF)

Motif affinity and mass spectrometry proteomic approach for the discovery of cellular AMPK targets: Identification of mitochondrial fission factor as a new AMPK substrate

Cellular signalling, 2015-05, Vol.27 (5), p.978-988

2015

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Activation of AMP-activated protein kinase in the liver: a new strategy for the management of metabolic hepatic disorders

The Journal of physiology, 2006-07, Vol.574 (1), p.41-53

2006

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AMPKα1‐LDH pathway regulates muscle stem cell self‐renewal by controlling metabolic homeostasis

The EMBO journal, 2017-07, Vol.36 (13), p.1946-1962

2017

Volltextzugriff (PDF)

TIM-4 Glycoprotein-Mediated Degradation of Dying Tumor Cells by Autophagy Leads to Reduced Antigen Presentation and Increased Immune Tolerance

Immunity (Cambridge, Mass.), 2013-12, Vol.39 (6), p.1070-1081

2013

Volltextzugriff (PDF)

Maintenance of Metabolic Homeostasis by Sestrin2 and Sestrin3

Cell metabolism, 2012-09, Vol.16 (3), p.311-321

2012

Volltextzugriff (PDF)

Leishmania infantum modulates host macrophage mitochondrial metabolism by hijacking the SIRT1-AMPK axis

PLoS pathogens, 2015-03, Vol.11 (3), p.e1004684-e1004684

2015

Volltextzugriff (PDF)

Mechanism of Action of A-769662, a Valuable Tool for Activation of AMP-activated Protein Kinase

The Journal of biological chemistry, 2007-11, Vol.282 (45), p.32549-32560

2007

Volltextzugriff (PDF)

The LKB1-salt-inducible kinase pathway functions as a key gluconeogenic suppressor in the liver

Nature communications, 2014-08, Vol.5 (1), p.4535, Article 4535

2014

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The AMPK-Sirtuin 1-YAP axis is regulated by fluid flow intensity and controls autophagy flux in kidney epithelial cells

Nature communications, 2023-12, Vol.14 (1), p.8056-8056, Article 8056

2023

Volltextzugriff (PDF)

AMPK deficiency in smooth muscles causes persistent pulmonary hypertension of the new-born and premature death

Nature communications, 2022-08, Vol.13 (1), p.5034-5034, Article 5034

2022

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Understanding the glucoregulatory mechanisms of metformin in type 2 diabetes mellitus

Metformin: From Mechanisms of Action to Therapies

Cellular and molecular mechanisms of metformin: an overview

AMPK Activation Reduces Hepatic Lipid Content by Increasing Fat Oxidation In Vivo

Obesity Impairs Skeletal Muscle Regeneration Through Inhibition of AMPK

Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state

AMPKα1 Regulates Macrophage Skewing at the Time of Resolution of Inflammation during Skeletal Muscle Regeneration

Anti-Inflammatory Effects of Metformin Irrespective of Diabetes Status

AMPK Re-Activation Suppresses Hepatic Steatosis but its Downregulation Does Not Promote Fatty Liver Development

Enhanced Muscle Insulin Sensitivity After Contraction/Exercise Is Mediated by AMPK

AMP-Activated Protein Kinase―Deficient Mice Are Resistant to the Metabolic Effects of Resveratrol

Aβ42 oligomers trigger synaptic loss through CAMKK2-AMPK-dependent effectors coordinating mitochondrial fission and mitophagy

Activation of Skeletal Muscle AMPK Promotes Glucose Disposal and Glucose Lowering in Non-human Primates and Mice

Activation of AMPKα2 in adipocytes is essential for nicotine-induced insulin resistance in vivo

SIKs control osteocyte responses to parathyroid hormone

Motif affinity and mass spectrometry proteomic approach for the discovery of cellular AMPK targets: Identification of mitochondrial fission factor as a new AMPK substrate

Activation of AMP-activated protein kinase in the liver: a new strategy for the management of metabolic hepatic disorders

AMPKα1‐LDH pathway regulates muscle stem cell self‐renewal by controlling metabolic homeostasis

TIM-4 Glycoprotein-Mediated Degradation of Dying Tumor Cells by Autophagy Leads to Reduced Antigen Presentation and Increased Immune Tolerance

Maintenance of Metabolic Homeostasis by Sestrin2 and Sestrin3

Leishmania infantum modulates host macrophage mitochondrial metabolism by hijacking the SIRT1-AMPK axis

Mechanism of Action of A-769662, a Valuable Tool for Activation of AMP-activated Protein Kinase

The LKB1-salt-inducible kinase pathway functions as a key gluconeogenic suppressor in the liver

The AMPK-Sirtuin 1-YAP axis is regulated by fluid flow intensity and controls autophagy flux in kidney epithelial cells

AMPK deficiency in smooth muscles causes persistent pulmonary hypertension of the new-born and premature death

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