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Deactivatable Bisubstrate Inhibitors of Protein Kinases

Molecules (Basel, Switzerland), 2022-10, Vol.27 (19), p.6689

2022

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Crystal Structure-Guided Design of Bisubstrate Inhibitors and Photoluminescent Probes for Protein Kinases of the PIM Family

Molecules (Basel, Switzerland), 2021-07, Vol.26 (14), p.4353

2021

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Acetoxymethyl Ester of Tetrabromobenzimidazole–Peptoid Conjugate for Inhibition of Protein Kinase CK2 in Living Cells

Bioconjugate chemistry, 2015-12, Vol.26 (12), p.2324-2335

2015

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Protein Cargo Delivery Properties of Cell-Penetrating Peptides. A Comparative Study

Bioconjugate chemistry, 2004-11, Vol.15 (6), p.1246-1253

2004

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Dissection of Protein Kinase Pathways in Live Cells Using Photoluminescent Probes: Surveillance or Interrogation?

Chemosensors, 2018-06, Vol.6 (2), p.19

2018

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Conjugation of Adenosine and Hexa-(d-arginine) Leads to a Nanomolar Bisubstrate-Analog Inhibitor of Basophilic Protein Kinases

Journal of medicinal chemistry, 2006-11, Vol.49 (24), p.7150-7159

2006

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Construction of Covalent Bisubstrate Inhibitor of Protein Kinase Reacting with Cysteine Residue at Substrate-Binding Site

Journal of medicinal chemistry, 2022-08, Vol.65 (16), p.10975-10991

2022

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Efficient photocaging of a tight-binding bisubstrate inhibitor of cAMP-dependent protein kinase

Chemical communications (Cambridge, England), 2019-09, Vol.55 (74), p.11147-1115

2019

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Oligo-aspartic acid conjugates with benzo[c][2,6]naphthyridine-8-carboxylic acid scaffold as picomolar inhibitors of CK2

Bioorganic & medicinal chemistry, 2017-04, Vol.25 (7), p.2277-2284

2017

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Thiazole- and selenazole-comprising high-affinity inhibitors possess bright microsecond-scale photoluminescence in complex with protein kinase CK2

Bioorganic & medicinal chemistry, 2018-10, Vol.26 (18), p.5062-5068

2018

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Discovery of strong inhibitory properties of a monoclonal antibody of PKA and use of the antibody and a competitive photoluminescent orthosteric probe for analysis of the protein kinase

Biochimica et biophysica acta. Proteins and proteomics, 2020-08, Vol.1868 (8), p.140427-140427, Article 140427

2020

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Binding assay for characterization of protein kinase inhibitors possessing sub-picomolar to sub-millimolar affinity

Analytical biochemistry, 2017-08, Vol.531, p.67-77

2017

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A Selective Biligand Inhibitor of CK2 Increases Caspase‐3 Activity in Cancer Cells and Inhibits Platelet Aggregation

ChemMedChem, 2017-10, Vol.12 (20), p.1723-1736

2017

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Slowly on, Slowly off: Bisubstrate‐Analogue Conjugates of 5‐Iodotubercidin and Histone H3 Peptide Targeting Protein Kinase Haspin

Chembiochem : a European journal of chemical biology, 2017-04, Vol.18 (8), p.790-798

2017

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Progesterone triggers Rho kinase-cofilin axis during in vitro and in vivo endometrial decidualization

Human reproduction (Oxford), 2021-08, Vol.36 (8), p.2230-2248

2021

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Long Residence Times Revealed by Aurora A Kinase-Targeting Fluorescent Probes Derived from Inhibitors MLN8237 and VX-689

Chembiochem : a European journal of chemical biology, 2014-02, Vol.15 (3), p.443-450

2014

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Unexpected CK2β-antagonistic functionality of bisubstrate inhibitors targeting protein kinase CK2

Bioorganic chemistry, 2020-03, Vol.96, p.103608-103608, Article 103608

2020

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Conjugates of adenosine mimetics and arginine‐rich peptides serve as inhibitors and fluorescent probes but not as long‐lifetime photoluminescent probes for protein arginine methyltransferases

Journal of peptide science, 2023-03, Vol.29 (3), p.e3456-n/a

2023

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High-affinity bisubstrate probe for fluorescence anisotropy binding/displacement assays with protein kinases PKA and ROCK

Analytical biochemistry, 2009-02, Vol.385 (1), p.85-93

2009

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Benzoselenadiazole-based responsive long-lifetime photoluminescent probes for protein kinases

Chemical communications (Cambridge, England), 2014-04, Vol.50 (31), p.4096-4098

2014

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Inside Cover: Long Residence Times Revealed by Aurora A Kinase-Targeting Fluorescent Probes Derived from Inhibitors MLN8237 and VX-689 (ChemBioChem 3/2014)

Chembiochem : a European journal of chemical biology, 2014-02, Vol.15 (3), p.338-338

2014

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FRET-based screening assay using small-molecule photoluminescent probes in lysate of cells overexpressing RFP-fused protein kinases

Analytical biochemistry, 2015-07, Vol.481, p.10-17

2015

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A subnanomolar fluorescent probe for protein kinase CK2 interaction studies

Organic & biomolecular chemistry, 2012-11, Vol.10 (43), p.8645-8653

2012

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Benzoselenadiazole-based responsive long-lifetime photoluminescent probes for protein kinasesElectronic supplementary information (ESI) available: Experimental details and further characterization. See DOI: 10.1039/c3cc49198f

2014-03

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Responsive microsecond-lifetime photoluminescent probes for analysis of protein kinases and their inhibitors

Biochimica et biophysica acta. Proteins and proteomics, 2013-07, Vol.1834 (7), p.1330-1335

2013

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Protein Kinase Inhibitors - Chemistry
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Protein Kinase Inhibitors - Pharmacology
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Kinases
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Protein Kinase
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Binding Sites
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Bisubstrate Inhibitor
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Chemistry, Analytical
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Deactivatable Bisubstrate Inhibitors of Protein Kinases

Crystal Structure-Guided Design of Bisubstrate Inhibitors and Photoluminescent Probes for Protein Kinases of the PIM Family

Acetoxymethyl Ester of Tetrabromobenzimidazole–Peptoid Conjugate for Inhibition of Protein Kinase CK2 in Living Cells

Protein Cargo Delivery Properties of Cell-Penetrating Peptides. A Comparative Study

Dissection of Protein Kinase Pathways in Live Cells Using Photoluminescent Probes: Surveillance or Interrogation?

Conjugation of Adenosine and Hexa-(d-arginine) Leads to a Nanomolar Bisubstrate-Analog Inhibitor of Basophilic Protein Kinases

Construction of Covalent Bisubstrate Inhibitor of Protein Kinase Reacting with Cysteine Residue at Substrate-Binding Site

Efficient photocaging of a tight-binding bisubstrate inhibitor of cAMP-dependent protein kinase

Oligo-aspartic acid conjugates with benzo[c][2,6]naphthyridine-8-carboxylic acid scaffold as picomolar inhibitors of CK2

Thiazole- and selenazole-comprising high-affinity inhibitors possess bright microsecond-scale photoluminescence in complex with protein kinase CK2

Discovery of strong inhibitory properties of a monoclonal antibody of PKA and use of the antibody and a competitive photoluminescent orthosteric probe for analysis of the protein kinase

Binding assay for characterization of protein kinase inhibitors possessing sub-picomolar to sub-millimolar affinity

A Selective Biligand Inhibitor of CK2 Increases Caspase‐3 Activity in Cancer Cells and Inhibits Platelet Aggregation

Slowly on, Slowly off: Bisubstrate‐Analogue Conjugates of 5‐Iodotubercidin and Histone H3 Peptide Targeting Protein Kinase Haspin

Progesterone triggers Rho kinase-cofilin axis during in vitro and in vivo endometrial decidualization

Long Residence Times Revealed by Aurora A Kinase-Targeting Fluorescent Probes Derived from Inhibitors MLN8237 and VX-689

Unexpected CK2β-antagonistic functionality of bisubstrate inhibitors targeting protein kinase CK2

Conjugates of adenosine mimetics and arginine‐rich peptides serve as inhibitors and fluorescent probes but not as long‐lifetime photoluminescent probes for protein arginine methyltransferases

High-affinity bisubstrate probe for fluorescence anisotropy binding/displacement assays with protein kinases PKA and ROCK

Benzoselenadiazole-based responsive long-lifetime photoluminescent probes for protein kinases

Inside Cover: Long Residence Times Revealed by Aurora A Kinase-Targeting Fluorescent Probes Derived from Inhibitors MLN8237 and VX-689 (ChemBioChem 3/2014)

FRET-based screening assay using small-molecule photoluminescent probes in lysate of cells overexpressing RFP-fused protein kinases

A subnanomolar fluorescent probe for protein kinase CK2 interaction studies

Benzoselenadiazole-based responsive long-lifetime photoluminescent probes for protein kinasesElectronic supplementary information (ESI) available: Experimental details and further characterization. See DOI: 10.1039/c3cc49198f

Responsive microsecond-lifetime photoluminescent probes for analysis of protein kinases and their inhibitors

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