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Pharmacokinetic/pharmacodynamic modeling in drug development

Annual review of pharmacology and toxicology, 2000-01, Vol.40 (1), p.67-95

2000

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Good Practices in Model‐Informed Drug Discovery and Development: Practice, Application, and Documentation

CPT: pharmacometrics and systems pharmacology, 2016-03, Vol.5 (3), p.93-122

2016

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Modelling response time profiles in the absence of drug concentrations: definition and performance evaluation of the K-PD model

Journal of pharmacokinetics and pharmacodynamics, 2007-02, Vol.34 (1), p.57-85

2007

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Pharmacokinetic Similarity of Biologics: Analysis Using Nonlinear Mixed-Effects Modeling

Clinical pharmacology and therapeutics, 2012-02, Vol.91 (2), p.234-242

2012

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Animal Health Modeling & Simulation Society: a new society promoting model-based approaches in veterinary pharmacology

Journal of Veterinary Pharmacology and Therapeutics, 2013-10, Vol.36 (5), p.417-419

2013

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Pharmacometrics: Opportunity for Reducing Disease Burden in the Developing World: The Case of Africa

CPT: pharmacometrics and systems pharmacology, 2013-08, Vol.2 (8), p.1-4

2013

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Modeling and Simulation to Optimize the Design and Analysis of Confirmatory Trials, Characterize Risk–Benefit, and Support Label Claims

CPT: pharmacometrics and systems pharmacology, 2013-02, Vol.2 (2), p.1-3

2013

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Pharmacometrics : modelling and simulation tools to improve decision making in clinical drug development

European journal of drug metabolism and pharmacokinetics, 2000-01, Vol.25 (1), p.49-58

2000

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Relationships between exposure to saquinavir monotherapy and antiviral response in HIV-positive patients

Clinical pharmacokinetics, 1999-07, Vol.37 (1), p.75-86

1999

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Role of modelling and simulation in Phase I drug development

European journal of pharmaceutical sciences, 2001-05, Vol.13 (2), p.115-122

2001

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Population pharmacokinetic analysis of the major metabolites of capecitabine

Journal of pharmacokinetics and pharmacodynamics, 2002-02, Vol.29 (1), p.25-47

2002

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The use of population pharmacokinetics in drug development

Clinical pharmacokinetics, 1996-02, Vol.30 (2), p.81-93

1996

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An evaluation of the integration of pharmacokinetic and pharmacodynamic principles in clinical drug development experience within Hoffmann La Roche

Clinical pharmacokinetics, 1997-08, Vol.33 (2), p.142-152

1997

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Population pharmacokinetics of levodopa in patients with Parkinson's disease treated with tolcapone

Clinical pharmacology and therapeutics, 2000-06, Vol.67 (6), p.610-620

2000

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Practical experience and issues in designing and performing population pharmacokinetic/pharmacodynamic studies

European journal of clinical pharmacology, 1996, Vol.49 (4), p.251-254

1996

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Population pharmacokinetics of tolcapone in parkinsonian patients in dose finding studies

British journal of clinical pharmacology, 2000-01, Vol.49 (1), p.39-48

2000

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Population approaches in drug development. Report on an expert meeting to discuss population pharmacokinetic/pharmacodynamic software

European journal of clinical pharmacology, 1994-06, Vol.46 (5), p.389-391

1994

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Simultaneous Pharmacokinetic Modeling of a Drug and Two Metabolites: Application to Albendazole in Sheep

Journal of pharmaceutical sciences, 1991-01, Vol.80 (1), p.3-10

1991

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Zero-order absorption and linear disposition of oral colchicine in healthy volunteers

European journal of clinical pharmacology, 1989, Vol.37 (1), p.79-84

1989

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Feedback control methods for drug dosage optimisation. Concepts, classification and clinical application

Clinical pharmacokinetics, 1985-01, Vol.10 (6), p.457-476

1985

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New strategies in drug development and clinical evaluation : the population approach : commentary on an action for co-operative research

European journal of clinical pharmacology, 1993-09, Vol.45 (2), p.93-94

1993

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A mathematical model of the kinetics of 5-fluorouracil and its metabolites in cancer patients

Cancer chemotherapy and pharmacology, 1991-01, Vol.28 (2), p.123-129

1991

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Pharmacokinetic aspects of the sublingual administration of vincamine

Biopharmaceutics & drug disposition, 1990-05, Vol.11 (4), p.279-309

1990

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Hyperparameter Estimation Using Stochastic Approximation with Application to Population Pharmacokinetics

Biometrics, 1988-09, Vol.44 (3), p.673-683

1988

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A semimechanistic and mechanistic population PK–PD model for biomarker response to ibandronate, a new bisphosphonate for the treatment of osteoporosis

British journal of clinical pharmacology, 2004-12, Vol.58 (6), p.618-631

2004

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Pharmacokinetic/pharmacodynamic modeling in drug development

Good Practices in Model‐Informed Drug Discovery and Development: Practice, Application, and Documentation

Modelling response time profiles in the absence of drug concentrations: definition and performance evaluation of the K-PD model

Pharmacokinetic Similarity of Biologics: Analysis Using Nonlinear Mixed-Effects Modeling

Animal Health Modeling & Simulation Society: a new society promoting model-based approaches in veterinary pharmacology

Pharmacometrics: Opportunity for Reducing Disease Burden in the Developing World: The Case of Africa

Modeling and Simulation to Optimize the Design and Analysis of Confirmatory Trials, Characterize Risk–Benefit, and Support Label Claims

Pharmacometrics : modelling and simulation tools to improve decision making in clinical drug development

Relationships between exposure to saquinavir monotherapy and antiviral response in HIV-positive patients

Role of modelling and simulation in Phase I drug development

Population pharmacokinetic analysis of the major metabolites of capecitabine

The use of population pharmacokinetics in drug development

An evaluation of the integration of pharmacokinetic and pharmacodynamic principles in clinical drug development experience within Hoffmann La Roche

Population pharmacokinetics of levodopa in patients with Parkinson's disease treated with tolcapone

Practical experience and issues in designing and performing population pharmacokinetic/pharmacodynamic studies

Population pharmacokinetics of tolcapone in parkinsonian patients in dose finding studies

Population approaches in drug development. Report on an expert meeting to discuss population pharmacokinetic/pharmacodynamic software

Simultaneous Pharmacokinetic Modeling of a Drug and Two Metabolites: Application to Albendazole in Sheep

Zero-order absorption and linear disposition of oral colchicine in healthy volunteers

Feedback control methods for drug dosage optimisation. Concepts, classification and clinical application

New strategies in drug development and clinical evaluation : the population approach : commentary on an action for co-operative research

A mathematical model of the kinetics of 5-fluorouracil and its metabolites in cancer patients

Pharmacokinetic aspects of the sublingual administration of vincamine

Hyperparameter Estimation Using Stochastic Approximation with Application to Population Pharmacokinetics

A semimechanistic and mechanistic population PK–PD model for biomarker response to ibandronate, a new bisphosphonate for the treatment of osteoporosis

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