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Synthesis of Cytotoxic Indenoisoquinoline Topoisomerase I Poisons

Journal of medicinal chemistry, 1999-02, Vol.42 (3), p.446-457

1999

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Some practical considerations and applications of the national cancer institute in vitro anticancer drug discovery screen

Drug development research, 1995-02, Vol.34 (2), p.91-109

1995

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Protein-Linked DNA Strand Breaks Induced by NSC 314622, a Novel Noncamptothecin Topoisomerase I Poison

Molecular pharmacology, 1998-07, Vol.54 (1), p.50-58

1998

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Identification of Epidermal Growth Factor Receptor and c-erbB2 Pathway Inhibitors by Correlation With Gene Expression Patterns

JNCI : Journal of the National Cancer Institute, 1997-10, Vol.89 (20), p.1505-1515

1997

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Evaluation of a soluble tetrazolium/formazan assay for cell growth and drug sensitivity in culture using human and other tumor cell lines

Cancer research (Chicago, Ill.), 1988-09, Vol.48 (17), p.4827-4833

1988

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Antitumor 2,3-dihydro-2-(aryl)-4(1 H)-quinazolinone derivatives : Interactions with tubulin

Biochemical pharmacology, 1996-01, Vol.51 (1), p.53-59

1996

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Neural Computing in Cancer Drug Development: Predicting Mechanism of Action

Science (American Association for the Advancement of Science), 1992-10, Vol.258 (5081), p.447-451

1992

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Identification of novel antimitotic agents acting at the tubulin level by computer-assisted evaluation of differential cytotoxicity data

Cancer research (Chicago, Ill.), 1992-07, Vol.52 (14), p.3892-3900

1992

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Synthesis and cytotoxicity of 1,6,7,8-substituted 2-(4'-substituted phenyl)-4-quinolones and related compounds: identification as antimitotic agents interacting with tubulin

Journal of medicinal chemistry, 1993-04, Vol.36 (9), p.1146-1156

1993

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Multidrug-resistant phenotype of disease-oriented panels of human tumor cell lines used for anticancer drug screening

Cancer research (Chicago, Ill.), 1992-06, Vol.52 (11), p.3029-3034

1992

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Mining and Visualizing Large Anticancer Drug Discovery Databases

Journal of Chemical Information and Computer Sciences, 2000-03, Vol.40 (2), p.367-379

2000

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Use of the Kohonen Self-organizing Map to Study the Mechanisms of Action of Chemotherapeutic Agents

JNCI : Journal of the National Cancer Institute, 1994-12, Vol.86 (24), p.1853-1859

1994

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Mining the National Cancer Institute Anticancer Drug Discovery Database: Cluster Analysis of Ellipticine Analogs with p53-Inverse and Central Nervous System-Selective Patterns of Activity

Molecular pharmacology, 1998-02, Vol.53 (2), p.241-251

1998

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Mining the NCI Anticancer Drug Discovery Databases: Genetic Function Approximation for the QSAR Study of Anticancer Ellipticine Analogues

Journal of Chemical Information and Computer Sciences, 1998-03, Vol.38 (2), p.189-199

1998

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Site of action of two novel pyrimidine biosynthesis inhibitors accurately predicted by the COMPARE program

Biochemical pharmacology, 1995-03, Vol.49 (7), p.947-954

1995

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Feasibility of a High-Flux Anticancer Drug Screen Using a Diverse Panel of Cultured Human Tumor Cell Lines

JNCI : Journal of the National Cancer Institute, 1991-06, Vol.83 (11), p.757-766

1991

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Design and Synthesis of Ellipticinium Salts and 1,2-Dihydroellipticines with High Selectivities against Human CNS Cancers in vitro

Journal of medicinal chemistry, 1994-07, Vol.37 (14), p.2190-2197

1994

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Reductase Enzyme Expression Across the National Cancer Institute Tumor Cell Line Panel: Correlation With Sensitivity to Mitomycin C and EO9

JNCI : Journal of the National Cancer Institute, 1996-03, Vol.88 (5), p.259-269

1996

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Halichondrin B and homohalichondrin B, marine natural products binding in the vinca domain of tubulin. Discovery of tubulin-based mechanism of action by analysis of differential cytotoxicity data

The Journal of biological chemistry, 1991-08, Vol.266 (24), p.15882-15889

1991

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Cytotoxicity of a new IMP dehydrogenase inhibitor, benzamide riboside, to human myelogenous leukemia K562 cells

Biochemical and biophysical research communications, 1992-08, Vol.186 (3), p.1600-1606

1992

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Cytotoxicity and characterization of an active metabolite of benzamide riboside, a novel inhibitor of IMP dehydrogenase

International journal of cancer, 1994-03, Vol.56 (6), p.892-899

1994

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An Information-Intensive Approach to the Molecular Pharmacology of Cancer

Science (American Association for the Advancement of Science), 1997-01, Vol.275 (5298), p.343-349

1997

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Topoisomerase II Inhibition and Cytotoxicity of the Anthrapyrazoles DuP 937 and DuP 941 (Losoxantrone) in the National Cancer Institute Preclinical Antitumor Drug Discovery Screen

JNCI : Journal of the National Cancer Institute, 1994-08, Vol.86 (16), p.1239-1244

1994

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Enhanced sensitivity to 1-β-D-arabinofuranosylcytosine and topoisomerase II inhibitors in tumor cell lines harboring activated ras oncogenes

Cancer research (Chicago, Ill.), 1996-11, Vol.56 (22), p.5211-5216

1996

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A protein expression database for the molecular pharmacology of cancer

Electrophoresis, 1997, Vol.18 (3-4), p.647-653

1997

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Synthesis of Cytotoxic Indenoisoquinoline Topoisomerase I Poisons

Some practical considerations and applications of the national cancer institute in vitro anticancer drug discovery screen

Protein-Linked DNA Strand Breaks Induced by NSC 314622, a Novel Noncamptothecin Topoisomerase I Poison

Identification of Epidermal Growth Factor Receptor and c-erbB2 Pathway Inhibitors by Correlation With Gene Expression Patterns

Evaluation of a soluble tetrazolium/formazan assay for cell growth and drug sensitivity in culture using human and other tumor cell lines

Antitumor 2,3-dihydro-2-(aryl)-4(1 H)-quinazolinone derivatives : Interactions with tubulin

Neural Computing in Cancer Drug Development: Predicting Mechanism of Action

Identification of novel antimitotic agents acting at the tubulin level by computer-assisted evaluation of differential cytotoxicity data

Synthesis and cytotoxicity of 1,6,7,8-substituted 2-(4'-substituted phenyl)-4-quinolones and related compounds: identification as antimitotic agents interacting with tubulin

Multidrug-resistant phenotype of disease-oriented panels of human tumor cell lines used for anticancer drug screening

Mining and Visualizing Large Anticancer Drug Discovery Databases

Use of the Kohonen Self-organizing Map to Study the Mechanisms of Action of Chemotherapeutic Agents

Mining the National Cancer Institute Anticancer Drug Discovery Database: Cluster Analysis of Ellipticine Analogs with p53-Inverse and Central Nervous System-Selective Patterns of Activity

Mining the NCI Anticancer Drug Discovery Databases: Genetic Function Approximation for the QSAR Study of Anticancer Ellipticine Analogues

Site of action of two novel pyrimidine biosynthesis inhibitors accurately predicted by the COMPARE program

Feasibility of a High-Flux Anticancer Drug Screen Using a Diverse Panel of Cultured Human Tumor Cell Lines

Design and Synthesis of Ellipticinium Salts and 1,2-Dihydroellipticines with High Selectivities against Human CNS Cancers in vitro

Reductase Enzyme Expression Across the National Cancer Institute Tumor Cell Line Panel: Correlation With Sensitivity to Mitomycin C and EO9

Halichondrin B and homohalichondrin B, marine natural products binding in the vinca domain of tubulin. Discovery of tubulin-based mechanism of action by analysis of differential cytotoxicity data

Cytotoxicity of a new IMP dehydrogenase inhibitor, benzamide riboside, to human myelogenous leukemia K562 cells

Cytotoxicity and characterization of an active metabolite of benzamide riboside, a novel inhibitor of IMP dehydrogenase

An Information-Intensive Approach to the Molecular Pharmacology of Cancer

Topoisomerase II Inhibition and Cytotoxicity of the Anthrapyrazoles DuP 937 and DuP 941 (Losoxantrone) in the National Cancer Institute Preclinical Antitumor Drug Discovery Screen

Enhanced sensitivity to 1-β-D-arabinofuranosylcytosine and topoisomerase II inhibitors in tumor cell lines harboring activated ras oncogenes

A protein expression database for the molecular pharmacology of cancer

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