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Mechanical regulation of cardiac fibroblast profibrotic phenotypes

Molecular biology of the cell, 2017-07, Vol.28 (14), p.1871-1882

2017

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Mechanical regulation of gene expression in cardiac myocytes and fibroblasts

Nature reviews cardiology, 2019-06, Vol.16 (6), p.361-378

2019

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Substrate Stiffness Affects the Functional Maturation of Neonatal Rat Ventricular Myocytes

Biophysical journal, 2008-10, Vol.95 (7), p.3479-3487

2008

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Systems Biophysics: Multiscale Biophysical Modeling of Organ Systems

Biophysical journal, 2016-03, Vol.110 (5), p.1023-1027

McCulloch, Andrew D.

2016

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Maintaining resting cardiac fibroblasts in vitro by disrupting mechanotransduction

PloS one, 2020-10, Vol.15 (10), p.e0241390-e0241390

2020

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HIF1α Represses Cell Stress Pathways to Allow Proliferation of Hypoxic Fetal Cardiomyocytes

Developmental cell, 2015-06, Vol.33 (5), p.507-521

2015

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Predictive model identifies key network regulators of cardiomyocyte mechano-signaling

PLoS computational biology, 2017-11, Vol.13 (11), p.e1005854-e1005854

2017

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Mechano-Electric Coupling and Arrhythmogenic Current Generation in a Computational Model of Coupled Myocytes

Frontiers in physiology, 2020-12, Vol.11, p.519951-519951

2020

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Isolation and reconstruction of cardiac mitochondria from SBEM images using a deep learning-based method

Journal of structural biology, 2022-03, Vol.214 (1), p.107806-107806, Article 107806

2022

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Computational Studies of the Effect of the S23D/S24D Troponin I Mutation on Cardiac Troponin Structural Dynamics

Biophysical journal, 2014-10, Vol.107 (7), p.1675-1685

2014

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PKA Phosphorylation of Cardiac Troponin I Modulates Activation and Relaxation Kinetics of Ventricular Myofibrils

Biophysical journal, 2014-09, Vol.107 (5), p.1196-1204

2014

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Biventricular shape modes discriminate pulmonary valve replacement in tetralogy of Fallot better than imaging indices

Scientific reports, 2023-02, Vol.13 (1), p.2335-2335, Article 2335

2023

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Histamine-induced biphasic activation of RhoA allows for persistent RhoA signaling

PLoS biology, 2020-09, Vol.18 (9), p.e3000866-e3000866

2020

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Nuclear mechanosignaling in striated muscle diseases

Frontiers in physiology, 2023-03, Vol.14, p.1126111-1126111

2023

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Subcellular Remodeling in Filamin C Deficient Mouse Hearts Impairs Myocyte Tension Development during Progression of Dilated Cardiomyopathy

International journal of molecular sciences, 2022-01, Vol.23 (2), p.871

2022

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How can AI accelerate advances in physiology?

The Journal of general physiology, 2023-06, Vol.155 (6)

McCulloch, Andrew D

2023

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Troponin I Mutations R146G and R21C Alter Cardiac Troponin Function, Contractile Properties, and Modulation by Protein Kinase A (PKA)-mediated Phosphorylation

The Journal of biological chemistry, 2015-11, Vol.290 (46), p.27749-27766

2015

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Mouse and computational models link Mlc2v dephosphorylation to altered myosin kinetics in early cardiac disease

The Journal of clinical investigation, 2012-04, Vol.122 (4), p.1209-1221

2012

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Endothelin receptor B, a candidate gene from human studies at high altitude, improves cardiac tolerance to hypoxia in genetically engineered heterozygote mice

Proceedings of the National Academy of Sciences - PNAS, 2015-08, Vol.112 (33), p.10425-10430

2015

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Right-left ventricular shape variations in tetralogy of Fallot: associations with pulmonary regurgitation

Journal of cardiovascular magnetic resonance, 2021-10, Vol.23 (1), p.105-105, Article 105

2021

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A deep learning approach for fully automated cardiac shape modeling in tetralogy of Fallot

Journal of cardiovascular magnetic resonance, 2023-02, Vol.25 (1), p.15-15, Article 15

2023

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A Computational Modeling and Simulation Approach to Investigate Mechanisms of Subcellular cAMP Compartmentation

PLoS computational biology, 2016-07, Vol.12 (7), p.e1005005-e1005005

2016

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Multi-scale Modeling of the Cardiovascular System: Disease Development, Progression, and Clinical Intervention

Annals of biomedical engineering, 2016-09, Vol.44 (9), p.2642-2660

2016

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Effects of Cardiac Troponin I Mutation P83S on Contractile Properties and the Modulation by PKA-Mediated Phosphorylation

The journal of physical chemistry. B, 2016-08, Vol.120 (33), p.8238-8253

2016

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Mechanical regulation of cardiac fibroblast profibrotic phenotypes

Mechanical regulation of gene expression in cardiac myocytes and fibroblasts

Substrate Stiffness Affects the Functional Maturation of Neonatal Rat Ventricular Myocytes

Systems Biophysics: Multiscale Biophysical Modeling of Organ Systems

Maintaining resting cardiac fibroblasts in vitro by disrupting mechanotransduction

HIF1α Represses Cell Stress Pathways to Allow Proliferation of Hypoxic Fetal Cardiomyocytes

Predictive model identifies key network regulators of cardiomyocyte mechano-signaling

Mechano-Electric Coupling and Arrhythmogenic Current Generation in a Computational Model of Coupled Myocytes

Lentiviral vectors and protocols for creation of stable hESC lines for fluorescent tracking and drug resistance selection of cardiomyocytes

Isolation and reconstruction of cardiac mitochondria from SBEM images using a deep learning-based method

Computational Studies of the Effect of the S23D/S24D Troponin I Mutation on Cardiac Troponin Structural Dynamics

PKA Phosphorylation of Cardiac Troponin I Modulates Activation and Relaxation Kinetics of Ventricular Myofibrils

Biventricular shape modes discriminate pulmonary valve replacement in tetralogy of Fallot better than imaging indices

Histamine-induced biphasic activation of RhoA allows for persistent RhoA signaling

Nuclear mechanosignaling in striated muscle diseases

Subcellular Remodeling in Filamin C Deficient Mouse Hearts Impairs Myocyte Tension Development during Progression of Dilated Cardiomyopathy

How can AI accelerate advances in physiology?

Troponin I Mutations R146G and R21C Alter Cardiac Troponin Function, Contractile Properties, and Modulation by Protein Kinase A (PKA)-mediated Phosphorylation

Mouse and computational models link Mlc2v dephosphorylation to altered myosin kinetics in early cardiac disease

Endothelin receptor B, a candidate gene from human studies at high altitude, improves cardiac tolerance to hypoxia in genetically engineered heterozygote mice

Right-left ventricular shape variations in tetralogy of Fallot: associations with pulmonary regurgitation

A deep learning approach for fully automated cardiac shape modeling in tetralogy of Fallot

A Computational Modeling and Simulation Approach to Investigate Mechanisms of Subcellular cAMP Compartmentation

Multi-scale Modeling of the Cardiovascular System: Disease Development, Progression, and Clinical Intervention

Effects of Cardiac Troponin I Mutation P83S on Contractile Properties and the Modulation by PKA-Mediated Phosphorylation

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