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L-Type amino acid transporter 1 as a target for drug delivery

Pharmaceutical research, 2020-05, Vol.37 (5), p.88-88, Article 88

2020

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L-type amino acid transporter 1 utilizing prodrugs: How to achieve effective brain delivery and low systemic exposure of drugs

Journal of controlled release, 2017-09, Vol.261, p.93-104

2017

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L-Type amino acid transporter 1 (LAT1)-utilizing prodrugs are carrier-selective despite having low affinity for organic anion transporting polypeptides (OATPs)

International journal of pharmaceutics, 2019-11, Vol.571, p.118714, Article 118714

2019

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Pharmacoproteomics of Brain Barrier Transporters and Substrate Design for the Brain Targeted Drug Delivery

Pharmaceutical research, 2022-07, Vol.39 (7), p.1363-1392

2022

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Comparative Modelling of Organic Anion Transporting Polypeptides: Structural Insights and Comparison of Binding Modes

Molecules (Basel, Switzerland), 2022-12, Vol.27 (23), p.8531

2022

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Hemocompatible LAT1-inhibitor can induce apoptosis in cancer cells without affecting brain amino acid homeostasis

Apoptosis (London), 2020-06, Vol.25 (5-6), p.426-440

2020

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A Selective and Slowly Reversible Inhibitor of l‑Type Amino Acid Transporter 1 (LAT1) Potentiates Antiproliferative Drug Efficacy in Cancer Cells

Journal of medicinal chemistry, 2016-06, Vol.59 (12), p.5740-5751

2016

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Structural Comparison of Sulfonamide-Based Derivatives That Can Improve Anti-Coagulation Properties of Metformin

International journal of molecular sciences, 2022-04, Vol.23 (8), p.4132

2022

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Incorporation of Sulfonamide Moiety into Biguanide Scaffold Results in Apoptosis Induction and Cell Cycle Arrest in MCF-7 Breast Cancer Cells

International journal of molecular sciences, 2021-05, Vol.22 (11), p.5642

2021

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Ganciclovir and Its Hemocompatible More Lipophilic Derivative Can Enhance the Apoptotic Effects of Methotrexate by Inhibiting Breast Cancer Resistance Protein (BCRP)

International journal of molecular sciences, 2021-07, Vol.22 (14), p.7727

2021

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Comparison of Experimental Strategies to Study l-Type Amino Acid Transporter 1 (LAT1) Utilization by Ligands

Molecules (Basel, Switzerland), 2021-12, Vol.27 (1), p.37

2021

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Effective Cellular Transport of Ortho -Halogenated Sulfonamide Derivatives of Metformin Is Related to Improved Antiproliferative Activity and Apoptosis Induction in MCF-7 Cells

International journal of molecular sciences, 2020-03, Vol.21 (7), p.2389

2020

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Pleiotropic Activity of Metformin and Its Sulfonamide Derivatives on Vascular and Platelet Haemostasis

Molecules (Basel, Switzerland), 2019-12, Vol.25 (1), p.125

2019

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Neurosteroids: Structure-Uptake Relationships and Computational Modeling of Organic Anion Transporting Polypeptides (OATP)1A2

Molecules (Basel, Switzerland), 2021-09, Vol.26 (18), p.5662

2021

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Astrocyte-Targeted Transporter-Utilizing Derivatives of Ferulic Acid Can Have Multifunctional Effects Ameliorating Inflammation and Oxidative Stress in the Brain

Oxidative medicine and cellular longevity, 2019, Vol.2019 (2019), p.1-13

2019

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Increased/Targeted Brain (Pro)Drug Delivery via Utilization of Solute Carriers (SLCs)

Pharmaceutics, 2022-06, Vol.14 (6), p.1234

2022

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Species differences in the intra-brain distribution of an L-type amino acid transporter 1 (LAT1) -utilizing compound between mice and rats

International journal of pharmaceutics, 2021-03, Vol.596, p.120300, Article 120300

2021

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Mechanistic Study on the Use of the l‑Type Amino Acid Transporter 1 for Brain Intracellular Delivery of Ketoprofen via Prodrug: A Novel Approach Supporting the Development of Prodrugs for Intracellular Targets

Molecular pharmaceutics, 2019-07, Vol.16 (7), p.3261-3274

2019

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Structural properties for selective and efficient l-type amino acid transporter 1 (LAT1) mediated cellular uptake

International journal of pharmaceutics, 2018-06, Vol.544 (1), p.91-99

2018

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Systemic and Brain Pharmacokinetics of Perforin Inhibitor Prodrugs

Molecular pharmaceutics, 2016-07, Vol.13 (7), p.2484-2491

2016

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Exploring the Biochemical Foundations of a Successful GLUT1-Targeting Strategy to BNCT: Chemical Synthesis and In Vitro Evaluation of the Entire Positional Isomer Library of ortho -Carboranylmethyl-Bearing Glucoconjugates

Molecular pharmaceutics, 2021-01, Vol.18 (1), p.285-304

2021

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Metformin – a Future Therapy for Neurodegenerative Diseases: Theme: Drug Discovery, Development and Delivery in Alzheimer's Disease Guest Editor: Davide Brambilla

Pharmaceutical research, 2017-12, Vol.34 (12), p.2614-2627

2017

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Metformin and its sulphonamide derivative simultaneously potentiateanti-cholinesterase activity of donepezil and inhibit beta-amyloid aggregation

Journal of enzyme inhibition and medicinal chemistry, 2018-01, Vol.33 (1), p.1309-1322

2018

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Amino Acid Promoieties Alter Valproic Acid Pharmacokinetics and Enable Extended Brain Exposure

Neurochemical research, 2016-10, Vol.41 (10), p.2797-2809

2016

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Novel Sulfonamide-Based Analogs of Metformin Exert Promising Anti-Coagulant Effects without Compromising Glucose-Lowering Activity

Pharmaceuticals (Basel, Switzerland), 2020-10, Vol.13 (10), p.323

2020

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L-Type amino acid transporter 1 as a target for drug delivery

L-type amino acid transporter 1 utilizing prodrugs: How to achieve effective brain delivery and low systemic exposure of drugs

L-Type amino acid transporter 1 (LAT1)-utilizing prodrugs are carrier-selective despite having low affinity for organic anion transporting polypeptides (OATPs)

Pharmacoproteomics of Brain Barrier Transporters and Substrate Design for the Brain Targeted Drug Delivery

Comparative Modelling of Organic Anion Transporting Polypeptides: Structural Insights and Comparison of Binding Modes

Hemocompatible LAT1-inhibitor can induce apoptosis in cancer cells without affecting brain amino acid homeostasis

A Selective and Slowly Reversible Inhibitor of l‑Type Amino Acid Transporter 1 (LAT1) Potentiates Antiproliferative Drug Efficacy in Cancer Cells

Structural Comparison of Sulfonamide-Based Derivatives That Can Improve Anti-Coagulation Properties of Metformin

Incorporation of Sulfonamide Moiety into Biguanide Scaffold Results in Apoptosis Induction and Cell Cycle Arrest in MCF-7 Breast Cancer Cells

Ganciclovir and Its Hemocompatible More Lipophilic Derivative Can Enhance the Apoptotic Effects of Methotrexate by Inhibiting Breast Cancer Resistance Protein (BCRP)

Comparison of Experimental Strategies to Study l-Type Amino Acid Transporter 1 (LAT1) Utilization by Ligands

Effective Cellular Transport of Ortho -Halogenated Sulfonamide Derivatives of Metformin Is Related to Improved Antiproliferative Activity and Apoptosis Induction in MCF-7 Cells

Pleiotropic Activity of Metformin and Its Sulfonamide Derivatives on Vascular and Platelet Haemostasis

Neurosteroids: Structure-Uptake Relationships and Computational Modeling of Organic Anion Transporting Polypeptides (OATP)1A2

Astrocyte-Targeted Transporter-Utilizing Derivatives of Ferulic Acid Can Have Multifunctional Effects Ameliorating Inflammation and Oxidative Stress in the Brain

Increased/Targeted Brain (Pro)Drug Delivery via Utilization of Solute Carriers (SLCs)

Species differences in the intra-brain distribution of an L-type amino acid transporter 1 (LAT1) -utilizing compound between mice and rats

Mechanistic Study on the Use of the l‑Type Amino Acid Transporter 1 for Brain Intracellular Delivery of Ketoprofen via Prodrug: A Novel Approach Supporting the Development of Prodrugs for Intracellular Targets

Structural properties for selective and efficient l-type amino acid transporter 1 (LAT1) mediated cellular uptake

Systemic and Brain Pharmacokinetics of Perforin Inhibitor Prodrugs

Exploring the Biochemical Foundations of a Successful GLUT1-Targeting Strategy to BNCT: Chemical Synthesis and In Vitro Evaluation of the Entire Positional Isomer Library of ortho -Carboranylmethyl-Bearing Glucoconjugates

Metformin – a Future Therapy for Neurodegenerative Diseases: Theme: Drug Discovery, Development and Delivery in Alzheimer's Disease Guest Editor: Davide Brambilla

Metformin and its sulphonamide derivative simultaneously potentiateanti-cholinesterase activity of donepezil and inhibit beta-amyloid aggregation

Amino Acid Promoieties Alter Valproic Acid Pharmacokinetics and Enable Extended Brain Exposure

Novel Sulfonamide-Based Analogs of Metformin Exert Promising Anti-Coagulant Effects without Compromising Glucose-Lowering Activity

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