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An Inducible Lentiviral Guide RNA Platform Enables the Identification of Tumor-Essential Genes and Tumor-Promoting Mutations In Vivo

Cell reports (Cambridge), 2015-03, Vol.10 (8), p.1422-1432

2015

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Loss of a Single Mcl-1 Allele Inhibits MYC-Driven Lymphomagenesis by Sensitizing Pro-B Cells to Apoptosis

Cell reports (Cambridge), 2016-03, Vol.14 (10), p.2337-2347

2016

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How does p53 induce apoptosis and how does this relate to p53-mediated tumour suppression?

Cell death and differentiation, 2018-01, Vol.25 (1), p.104-113

2018

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Therapeutic Response to Non-genotoxic Activation of p53 by Nutlin3a Is Driven by PUMA-Mediated Apoptosis in Lymphoma Cells

Cell reports (Cambridge), 2016-03, Vol.14 (8), p.1858-1866

2016

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Tumor-Suppressor Functions of the TP53 Pathway

Cold Spring Harbor perspectives in medicine, 2016-05, Vol.6 (5), p.a026062

2016

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RAG-induced DNA lesions activate proapoptotic BIM to suppress lymphomagenesis in p53-deficient mice

The Journal of experimental medicine, 2016-09, Vol.213 (10), p.2039-2048

2016

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SOHO State of the Art and Next Questions: Treatment of Higher-Risk Myelodysplastic Syndromes

Clinical lymphoma, myeloma and leukemia, 2022-12, Vol.22 (12), p.869-877

2022

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Targeting of MCL-1 kills MYC-driven mouse and human lymphomas even when they bear mutations in p53

Genes & development, 2014-01, Vol.28 (1), p.58-70

2014

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Genome-wide CRISPR screening identifies a role for ARRDC3 in TRP53-mediated responses

Cell death and differentiation, 2024-02, Vol.31 (2), p.150-158

2024

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Loss of TRP53 reduces but does not overcome dependency of lymphoma cells on MCL-1

Cell death and differentiation, 2022-05, Vol.29 (5), p.1074-1076

2022

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MOZ and Menin-MLL Complexes Are Complementary Regulators of Chromatin Association and Transcriptional Output in Gastrointestinal Stromal Tumor

Cancer discovery, 2022-07, Vol.12 (7), p.1804-1823

2022

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Mutant TRP53 exerts a target gene-selective dominant-negative effect to drive tumor development

Genes & development, 2018-11, Vol.32 (21-22), p.1420-1429

2018

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The BH3-only proteins BIM and PUMA are not critical for the reticulocyte apoptosis caused by loss of the pro-survival protein BCL-XL

Cell death & disease, 2017-07, Vol.8 (7), p.e2914-e2914

2017

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Potent Ikaros Degradation By the Cereblon E3 Ligase Modulator CC-92480 Is Effective in Combination with Menin-MLL1 Inhibition in MLL1-Rearranged and NPM1-Mutant AML

Blood, 2021-11, Vol.138 (Supplement 1), p.208-208

2021

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Mutant p53 Enhances the Development and Sustained Growth of MYC-Driven Lymphoma and Exerts a Dominant Negative Effect Preferentially Deregulating Pathways for Metabolism and DNA Repair

Blood, 2016-12, Vol.128 (22), p.1545-1545

2016

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International trends in incidence of osteosarcoma (1988‐2012)

International journal of cancer, 2021-09, Vol.149 (5), p.1044-1053

2021

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Comparative international incidence of Ewing sarcoma 1988 to 2012

International journal of cancer, 2021-09, Vol.149 (5), p.1054-1066

2021

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New Food Crop Domestication in the Age of Gene Editing: Genetic, Agronomic and Cultural Change Remain Co-evolutionarily Entangled

Frontiers in plant science, 2020-06, Vol.11, p.789-789

2020

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Protocol for multiplex fluorescent immunohistochemistry in free-floating rodent brain tissues

STAR protocols, 2022-12, Vol.3 (4), p.101672-101672, Article 101672

2022

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Species-typical group size differentially influences social reward neural circuitry during nonreproductive social interactions

iScience, 2022-05, Vol.25 (5), p.104230, Article 104230

2022

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Advancing the Sustainable Development Goals through improving eye health: a scoping review

The Lancet. Planetary health, 2022-03, Vol.6 (3), p.e270-e280

2022

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Odanacatib for the treatment of postmenopausal osteoporosis: results of the LOFT multicentre, randomised, double-blind, placebo-controlled trial and LOFT Extension study

The lancet. Diabetes & endocrinology, 2019-12, Vol.7 (12), p.899-911

2019

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Tumor Suppressor Protein P53 - Genetics
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Apoptosis Regulatory Proteins - Genetics
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An Inducible Lentiviral Guide RNA Platform Enables the Identification of Tumor-Essential Genes and Tumor-Promoting Mutations In Vivo

Loss of a Single Mcl-1 Allele Inhibits MYC-Driven Lymphomagenesis by Sensitizing Pro-B Cells to Apoptosis

How does p53 induce apoptosis and how does this relate to p53-mediated tumour suppression?

Therapeutic Response to Non-genotoxic Activation of p53 by Nutlin3a Is Driven by PUMA-Mediated Apoptosis in Lymphoma Cells

Tumor-Suppressor Functions of the TP53 Pathway

RAG-induced DNA lesions activate proapoptotic BIM to suppress lymphomagenesis in p53-deficient mice

SOHO State of the Art and Next Questions: Treatment of Higher-Risk Myelodysplastic Syndromes

Intact TP-53 function is essential for sustaining durable responses to BH3-mimetic drugs in leukemias

Targeting of MCL-1 kills MYC-driven mouse and human lymphomas even when they bear mutations in p53

Genome-wide CRISPR screening identifies a role for ARRDC3 in TRP53-mediated responses

Loss of TRP53 reduces but does not overcome dependency of lymphoma cells on MCL-1

MOZ and Menin-MLL Complexes Are Complementary Regulators of Chromatin Association and Transcriptional Output in Gastrointestinal Stromal Tumor

Mutant TRP53 exerts a target gene-selective dominant-negative effect to drive tumor development

PHF6 regulates hematopoietic stem and progenitor cells and its loss synergizes with expression of TLX3 to cause leukemia

The BH3-only proteins BIM and PUMA are not critical for the reticulocyte apoptosis caused by loss of the pro-survival protein BCL-XL

Potent Ikaros Degradation By the Cereblon E3 Ligase Modulator CC-92480 Is Effective in Combination with Menin-MLL1 Inhibition in MLL1-Rearranged and NPM1-Mutant AML

Mutant p53 Enhances the Development and Sustained Growth of MYC-Driven Lymphoma and Exerts a Dominant Negative Effect Preferentially Deregulating Pathways for Metabolism and DNA Repair

International trends in incidence of osteosarcoma (1988‐2012)

Comparative international incidence of Ewing sarcoma 1988 to 2012

New Food Crop Domestication in the Age of Gene Editing: Genetic, Agronomic and Cultural Change Remain Co-evolutionarily Entangled

Protocol for multiplex fluorescent immunohistochemistry in free-floating rodent brain tissues

Species-typical group size differentially influences social reward neural circuitry during nonreproductive social interactions

Patient reported dry mouth: Instrument comparison and model performance for correlation with quality of life in head and neck cancer survivors

Advancing the Sustainable Development Goals through improving eye health: a scoping review

Odanacatib for the treatment of postmenopausal osteoporosis: results of the LOFT multicentre, randomised, double-blind, placebo-controlled trial and LOFT Extension study

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