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Discovery of AB680: A Potent and Selective Inhibitor of CD73

Journal of medicinal chemistry, 2020-10, Vol.63 (20), p.11448-11468

2020

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Safety, tolerability, and pharmacology of AB928, a novel dual adenosine receptor antagonist, in a randomized, phase 1 study in healthy volunteers

Investigational new drugs, 2019-08, Vol.37 (4), p.711-721

2019

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Lunatic and Manic Fringe Cooperatively Enhance Marginal Zone B Cell Precursor Competition for Delta-like 1 in Splenic Endothelial Niches

Immunity (Cambridge, Mass.), 2009-02, Vol.30 (2), p.254-263

2009

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Targeting CD73 with AB680 (Quemliclustat), a Novel and Potent Small-Molecule CD73 Inhibitor, Restores Immune Functionality and Facilitates Antitumor Immunity

Molecular cancer therapeutics, 2022-06, Vol.21 (6), p.948-959

2022

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Requirement for Notch1 signals at sequential early stages of intrathymic T cell development

Nature Immunology, 2005-07, Vol.6 (7), p.671-679

2005

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Regulation of T lymphopoiesis by Notch1 and Lunatic fringe-mediated competition for intrathymic niches

Nature Immunology, 2006-06, Vol.7 (6), p.634-643

2006

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Regulation of intrathymic T-cell development by Lunatic Fringe- Notch1 interactions

Immunological reviews, 2006-02, Vol.209 (1), p.76-94

2006

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Lunatic Fringe prolongs Delta/Notch-induced self-renewal of committed αβ T-cell progenitors

Blood, 2011-01, Vol.117 (4), p.1184-1195

2011

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Abstract 1557: Characterization of AB154, a humanized anti-TIGIT antibody, for use in combination studies

Cancer research (Chicago, Ill.), 2019-07, Vol.79 (13_Supplement), p.1557-1557

2019

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Abstract 4561: Preclinical characterization of GLS-010 (AB122): A fully humanized clinical-stage anti-PD-1 antibody

Cancer research (Chicago, Ill.), 2018-07, Vol.78 (13_Supplement), p.4561-4561

2018

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Abstract 3168: Methods for assessment of the “adenosine fingerprint” in clinical trials of AB928

Cancer research (Chicago, Ill.), 2019-07, Vol.79 (13_Supplement), p.3168-3168

2019

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Abstract 2640: Small-molecule inhibitors of CD73, CD39 and A2aR: Three anti-cancer targets in the ATP/adenosine signaling pathway

Cancer research (Chicago, Ill.), 2017-07, Vol.77 (13_Supplement), p.2640-2640

2017

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Full CD34 Donor Chimerism Following CD34 Chimerism Directed Donor Lymphocyte Infusion Results in Reduced Relapse and Superior Overall Survival Compared with Mixed Chimerism Status in Allogeneic Haemopoietic Stem Cell Transplant Recipients

Blood, 2023-11, Vol.142 (Supplement 1), p.2239-2239

2023

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Abstract 710: CD73 inhibitors (CD73i) reverse the AMP/adenosine-mediated impairment of immune effector cell activation by immune checkpoint inhibitors (ICI)

Cancer research (Chicago, Ill.), 2018-07, Vol.78 (13_Supplement), p.710-710

2018

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Abstract 6004: Surveying surface antigen expression in multiple myeloma preclinical models

Cancer research (Chicago, Ill.), 2022-06, Vol.82 (12_Supplement), p.6004-6004

2022

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Abstract 4572: Characterization of the potent and selective A2aR antagonist AB928 for the treatment of cancer

Cancer research (Chicago, Ill.), 2017-07, Vol.77 (13_Supplement), p.4572-4572

2017

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Sgr-1505 Is a Potent MALT1 Protease Inhibitor with a Potential Best-in-Class Profile

Blood, 2023-11, Vol.142 (Supplement 1), p.2997-2997

2023

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A Phase 1, Open-Label, Multicenter, Dose-Escalation Study of Sgr-1505 As Monotherapy in Subjects with Mature B-Cell Malignancies

Blood, 2023-11, Vol.142 (Supplement 1), p.3102-3102

2023

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Haploidentical Donor Transplants with Cytokine Release Syndrome Have Increased Risk of Clinically Significant Early CMV Reactivation Compared with Matched Donor Transplants Receiving Post-Transplant Cyclophosphamide

Blood, 2023-11, Vol.142 (Supplement 1), p.6955-6955

2023

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Abstract B46: Small-molecule inhibitors of ecto-nucleotidase CD73 promote activation of human CD8+ T cells and have profound effects on tumor growth and immune parameters in experimental tumor models

Cancer immunology research, 2017-03, Vol.5 (3_Supplement), p.B46-B46

2017

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Regulation of intrathymic T-cell development by Lunatic Fringe-Notch1 interactions: Thymus and lymphocyte development

Immunological reviews, 2006, Vol.209, p.76-94

2006

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Erratum: Requirement for Notch1 signals at sequential early stages of intrathymic T cell development

Nature immunology, 2005-09, Vol.6 (9), p.954-954

2005

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The relationship of self-efficacy to catastrophizing and depressive symptoms in community-dwelling older adults with chronic pain: A moderated mediation model

PloS one, 2018-09, Vol.13 (9), p.e0203964-e0203964

2018

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Serum Level of Soluble Receptor for Advanced Glycation End Products Is Associated with A Disintegrin And Metalloproteinase 10 in Type 1 Diabetes

PloS one, 2015-09, Vol.10 (9), p.e0137330-e0137330

2015

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Severity of mucositis during allogeneic transplantation impacts post-transplant cyclosporin absorption

Bone marrow transplantation (Basingstoke), 2020-09, Vol.55 (9), p.1857-1859

2020

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Discovery of AB680: A Potent and Selective Inhibitor of CD73

Safety, tolerability, and pharmacology of AB928, a novel dual adenosine receptor antagonist, in a randomized, phase 1 study in healthy volunteers

Lunatic and Manic Fringe Cooperatively Enhance Marginal Zone B Cell Precursor Competition for Delta-like 1 in Splenic Endothelial Niches

Targeting CD73 with AB680 (Quemliclustat), a Novel and Potent Small-Molecule CD73 Inhibitor, Restores Immune Functionality and Facilitates Antitumor Immunity

Requirement for Notch1 signals at sequential early stages of intrathymic T cell development

Regulation of T lymphopoiesis by Notch1 and Lunatic fringe-mediated competition for intrathymic niches

Regulation of intrathymic T-cell development by Lunatic Fringe- Notch1 interactions

Lunatic Fringe prolongs Delta/Notch-induced self-renewal of committed αβ T-cell progenitors

Abstract 1557: Characterization of AB154, a humanized anti-TIGIT antibody, for use in combination studies

Abstract 4561: Preclinical characterization of GLS-010 (AB122): A fully humanized clinical-stage anti-PD-1 antibody

Abstract 3168: Methods for assessment of the “adenosine fingerprint” in clinical trials of AB928

Abstract 2640: Small-molecule inhibitors of CD73, CD39 and A2aR: Three anti-cancer targets in the ATP/adenosine signaling pathway

Full CD34 Donor Chimerism Following CD34 Chimerism Directed Donor Lymphocyte Infusion Results in Reduced Relapse and Superior Overall Survival Compared with Mixed Chimerism Status in Allogeneic Haemopoietic Stem Cell Transplant Recipients

Abstract 710: CD73 inhibitors (CD73i) reverse the AMP/adenosine-mediated impairment of immune effector cell activation by immune checkpoint inhibitors (ICI)

Abstract 6004: Surveying surface antigen expression in multiple myeloma preclinical models

Abstract 4572: Characterization of the potent and selective A2aR antagonist AB928 for the treatment of cancer

Sgr-1505 Is a Potent MALT1 Protease Inhibitor with a Potential Best-in-Class Profile

A Phase 1, Open-Label, Multicenter, Dose-Escalation Study of Sgr-1505 As Monotherapy in Subjects with Mature B-Cell Malignancies

Haploidentical Donor Transplants with Cytokine Release Syndrome Have Increased Risk of Clinically Significant Early CMV Reactivation Compared with Matched Donor Transplants Receiving Post-Transplant Cyclophosphamide

Abstract B46: Small-molecule inhibitors of ecto-nucleotidase CD73 promote activation of human CD8+ T cells and have profound effects on tumor growth and immune parameters in experimental tumor models

Regulation of intrathymic T-cell development by Lunatic Fringe-Notch1 interactions: Thymus and lymphocyte development

Erratum: Requirement for Notch1 signals at sequential early stages of intrathymic T cell development

The relationship of self-efficacy to catastrophizing and depressive symptoms in community-dwelling older adults with chronic pain: A moderated mediation model

Serum Level of Soluble Receptor for Advanced Glycation End Products Is Associated with A Disintegrin And Metalloproteinase 10 in Type 1 Diabetes

Severity of mucositis during allogeneic transplantation impacts post-transplant cyclosporin absorption

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