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TREM2- and DAP12-dependent activation of PI3K requires DAP10 and is inhibited by SHIP1

Science signaling, 2010-05, Vol.3 (122), p.ra38

2010

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Pan-SHIP1/2 inhibitors promote microglia effector functions essential for CNS homeostasis

Journal of cell science, 2020-01, Vol.133 (5)

2020

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Inhibiting Stat3 signaling in the hematopoietic system elicits multicomponent antitumor immunity

Nature medicine, 2005-12, Vol.11 (12), p.1314-1321

2005

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Structure-Activity Studies on Bis-Sulfonamide SHIP1 Activators

Molecules (Basel, Switzerland), 2023-12, Vol.28 (24), p.8048

2023

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Role of SHIP1 in cancer and mucosal inflammation

Annals of the New York Academy of Sciences, 2013-03, Vol.1280 (1), p.6-10

2013

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SHIP-1 Couples to the Dectin-1 hemITAM and Selectively Modulates Reactive Oxygen Species Production in Dendritic Cells in Response to Candida albicans

The Journal of immunology (1950), 2015-11, Vol.195 (9), p.4466-4478

2015

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N1 -Benzyl Tryptamine Pan-SHIP1/2 Inhibitors: Synthesis and Preliminary Biological Evaluation as Anti-Tumor Agents

Molecules (Basel, Switzerland), 2022-12, Vol.27 (23), p.8451

2022

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Selective deletion of SHIP-1 in hematopoietic cells in mice leads to severe lung inflammation involving ILC2 cells

Scientific reports, 2021-04, Vol.11 (1), p.9220-9220, Article 9220

2021

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The Next Generation of Immunotherapy for Cancer: Small Molecules Could Make Big Waves

The Journal of immunology (1950), 2019-01, Vol.202 (1), p.11-19

2019

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LRBA Deficiency Can Lead to Lethal Colitis That Is Diminished by SHIP1 Agonism

Frontiers in immunology, 2022-05, Vol.13, p.830961-830961

2022

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SHIP1 Inhibition Increases Immunoregulatory Capacity and Triggers Apoptosis of Hematopoietic Cancer Cells

The Journal of immunology (1950), 2010-04, Vol.184 (7), p.3582-3589

2010

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Therapeutic potential of SH2 domain-containing inositol-5'-phosphatase 1 (SHIP1) and SHIP2 inhibition in cancer

Molecular medicine (Cambridge, Mass.), 2012-01, Vol.18 (1), p.65-75

2012

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Analysis of SHIP1 expression and activity in Crohn's disease patients

PloS one, 2017-08, Vol.12 (8), p.e0182308-e0182308

2017

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Inhibitor and activator: dual functions for SHIP in immunity and cancer

Annals of the New York Academy of Sciences, 2011-01, Vol.1217 (1), p.1-17

Kerr, William G.

2011

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SHIP1 Deficiency in Inflammatory Bowel Disease Is Associated With Severe Crohn's Disease and Peripheral T Cell Reduction

Frontiers in immunology, 2018-05, Vol.9, p.1100-1100

2018

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Lipid phosphatase SHIP2 functions as oncogene in colorectal cancer by regulating PKB activation

Oncotarget, 2016-11, Vol.7 (45), p.73525-73540

2016

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Mouse natural killer cell development and maturation are differentially regulated by SHIP-1

Blood, 2012-11, Vol.120 (23), p.4583-4590

2012

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Obesity control by SHIP inhibition requires pan-paralog inhibition and an intact eosinophil compartment

iScience, 2023-02, Vol.26 (2), p.106071-106071, Article 106071

2023

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SHIP1 intrinsically regulates NK cell signaling and education, resulting in tolerance of an MHC class I-mismatched bone marrow graft in mice

The Journal of immunology (1950), 2015-03, Vol.194 (6), p.2847-2854

2015

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SHIP‐1, a target of miR‐155, regulates endothelial cell responses in lung fibrosis

The FASEB journal, 2020-02, Vol.34 (2), p.2011-2023

2020

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Quorum sensing contributes to activated IgM-secreting B cell homeostasis

The Journal of immunology (1950), 2013-01, Vol.190 (1), p.106-114

2013

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Small molecule targeting of SHIP1 and SHIP2

Biochemical Society transactions, 2020-02, Vol.48 (1), p.291-300

2020

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Targeting SHIP-1 in Myeloid Cells Enhances Trained Immunity and Boosts Response to Infection

Cell reports (Cambridge), 2018-10, Vol.25 (5), p.1118-1126

2018

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SHIP represses Th2 skewing by inhibiting IL-4 production from basophils

The Journal of immunology (1950), 2011-01, Vol.186 (1), p.323-332

2011

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Induced SHIP Deficiency Expands Myeloid Regulatory Cells and Abrogates Graft-versus-Host Disease

Journal of Immunology, 2007-03, Vol.178 (5), p.2893-2900

2007

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TREM2- and DAP12-dependent activation of PI3K requires DAP10 and is inhibited by SHIP1

Pan-SHIP1/2 inhibitors promote microglia effector functions essential for CNS homeostasis

Inhibiting Stat3 signaling in the hematopoietic system elicits multicomponent antitumor immunity

Structure-Activity Studies on Bis-Sulfonamide SHIP1 Activators

Role of SHIP1 in cancer and mucosal inflammation

SHIP-1 Couples to the Dectin-1 hemITAM and Selectively Modulates Reactive Oxygen Species Production in Dendritic Cells in Response to Candida albicans

N1 -Benzyl Tryptamine Pan-SHIP1/2 Inhibitors: Synthesis and Preliminary Biological Evaluation as Anti-Tumor Agents

Selective deletion of SHIP-1 in hematopoietic cells in mice leads to severe lung inflammation involving ILC2 cells

The Next Generation of Immunotherapy for Cancer: Small Molecules Could Make Big Waves

LRBA Deficiency Can Lead to Lethal Colitis That Is Diminished by SHIP1 Agonism

SHIP1 Inhibition Increases Immunoregulatory Capacity and Triggers Apoptosis of Hematopoietic Cancer Cells

Therapeutic potential of SH2 domain-containing inositol-5'-phosphatase 1 (SHIP1) and SHIP2 inhibition in cancer

Analysis of SHIP1 expression and activity in Crohn's disease patients

Inhibitor and activator: dual functions for SHIP in immunity and cancer

SHIP1 Deficiency in Inflammatory Bowel Disease Is Associated With Severe Crohn's Disease and Peripheral T Cell Reduction

Lipid phosphatase SHIP2 functions as oncogene in colorectal cancer by regulating PKB activation

Mouse natural killer cell development and maturation are differentially regulated by SHIP-1

Obesity control by SHIP inhibition requires pan-paralog inhibition and an intact eosinophil compartment

SHIP1 intrinsically regulates NK cell signaling and education, resulting in tolerance of an MHC class I-mismatched bone marrow graft in mice

SHIP‐1, a target of miR‐155, regulates endothelial cell responses in lung fibrosis

Quorum sensing contributes to activated IgM-secreting B cell homeostasis

Small molecule targeting of SHIP1 and SHIP2

Targeting SHIP-1 in Myeloid Cells Enhances Trained Immunity and Boosts Response to Infection

SHIP represses Th2 skewing by inhibiting IL-4 production from basophils

Induced SHIP Deficiency Expands Myeloid Regulatory Cells and Abrogates Graft-versus-Host Disease

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