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Locked nucleic acid: modality, diversity, and drug discovery

Drug discovery today, 2018-01, Vol.23 (1), p.101-114

2018

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MicroRNA-219 modulates NMDA receptor-mediated neurobehavioral dysfunction

Proceedings of the National Academy of Sciences - PNAS, 2009-03, Vol.106 (9), p.3507-3512

2009

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Pharmacological inhibition of a microRNA family in nonhuman primates by a seed-targeting 8-mer antimiR

Science translational medicine, 2013-11, Vol.5 (212), p.212ra162

2013

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Electronic Structures of LNA Phosphorothioate Oligonucleotides

Molecular therapy. Nucleic acids, 2017-09, Vol.8, p.428-441

2017

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PCSK9 LNA Antisense Oligonucleotides Induce Sustained Reduction of LDL Cholesterol in Nonhuman Primates

Molecular therapy, 2012-02, Vol.20 (2), p.376-381

2012

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Identifying and avoiding off-target effects of RNase H-dependent antisense oligonucleotides in mice

Nucleic acids research, 2018-06, Vol.46 (11), p.5366-5380

2018

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Solid-Phase synthesis of peptide nucleic acids

Journal of peptide science, 1995-05, Vol.1 (3), p.175-183

1995

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PNA synthesis using a novel Boc/acyl protecting group strategy

Journal of peptide science, 2001-08, Vol.7 (8), p.402-412

2001

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Expanding the design horizon of antisense oligonucleotides with alpha-L-LNA

Nucleic acids research, 2003-11, Vol.31 (21), p.6365-6372

2003

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Nuclease Stability of LNA Oligonucleotides and LNA-DNA Chimeras

Nucleosides, nucleotides & nucleic acids, 2003-10, Vol.22 (5-8), p.1041-1043

2003

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Synthesis of Peptide Nucleic Acid Monomers Containing the Four Natural Nucleobases: Thymine, Cytosine, Adenine, and Guanine and Their Oligomerization

Journal of organic chemistry, 1994-09, Vol.59 (19), p.5767-5773

1994

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Molar-Scale Synthesis of 1,2:5,6-Di-O-isopropylidene-α-d-allofuranose: DMSO Oxidation of 1,2:5,6-Di-O-isopropylidene-α-d-glucofuranose and Subsequent Sodium Borohydride Reduction

Organic process research & development, 2004-09, Vol.8 (5), p.777-780

2004

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Effect of LNA Modifications on Small Molecule Binding to Nucleic Acids

Journal of biomolecular structure & dynamics, 2004-06, Vol.21 (6), p.841-850

2004

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New Standards in LNA Synthesis

Nucleosides, nucleotides & nucleic acids, 2003-10, Vol.22 (5-8), p.1273-1275

2003

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Increased DNA binding and sequence discrimination of PNA oligomers containing 2,6-diaminopurine

Nucleic acids research, 1997-11, Vol.25 (22), p.4639-4643

1997

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Linker length in podophyllotoxin-acridine conjugates determines potency in vivo and in vitro as well as specificity against MDR cell lines

Anti-cancer drug design, 2001-12, Vol.16 (6), p.305

2001

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siRNA Versus Antisense Locked Nucleic Acids: Stay Single

Blood, 2005-11, Vol.106 (11), p.614-614

2005

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SPC2996 - A New Bcl-2 Inhibitor for the Treatment of CLL

Blood, 2005-11, Vol.106 (11), p.2984-2984

2005

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New compounds related to podophyllotoxin and congeners: synthesis, structure elucidation and biological testing

Acta chemica Scandinavica (Copenhagen. 1989), 1993-12, Vol.47 (12), p.1190-1200

1993

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Improvements in automated PNA synthesis using Boc/Z monomers

The journal of peptide research, 1997-01, Vol.49 (1), p.80-88

1997

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Inhibition of PNA triplex formation by N4-benzoylated cytosine

Nucleic acids research, 1998-06, Vol.26 (11), p.2735-2739

1998

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6-Thioguanine in Peptide Nucleic Acids. Synthesis and Hybridization Properties

Nucleosides & nucleotides, 1999-01, Vol.18 (1), p.5-9

1999

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New Standards in LNA Synthesis

ChemInform, 2004-02, Vol.35 (7), p.no-no

2004

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Nuclease Stability of LNA Oligonucleotides and LNA-DNA Chimeras

ChemInform, 2004-02, Vol.35 (6), p.no-no

2004

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Thermal Chemistry of Podophyllotoxin in Ethanol and a Comparison of the Cytostatic Activity of the Thermolysis Products

Journal of pharmaceutical sciences, 1986-11, Vol.75 (11), p.1076-1080

1986

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Locked nucleic acid: modality, diversity, and drug discovery

MicroRNA-219 modulates NMDA receptor-mediated neurobehavioral dysfunction

Pharmacological inhibition of a microRNA family in nonhuman primates by a seed-targeting 8-mer antimiR

Electronic Structures of LNA Phosphorothioate Oligonucleotides

PCSK9 LNA Antisense Oligonucleotides Induce Sustained Reduction of LDL Cholesterol in Nonhuman Primates

Identifying and avoiding off-target effects of RNase H-dependent antisense oligonucleotides in mice

Solid-Phase synthesis of peptide nucleic acids

PNA synthesis using a novel Boc/acyl protecting group strategy

Expanding the design horizon of antisense oligonucleotides with alpha-L-LNA

Nuclease Stability of LNA Oligonucleotides and LNA-DNA Chimeras

Synthesis of Peptide Nucleic Acid Monomers Containing the Four Natural Nucleobases: Thymine, Cytosine, Adenine, and Guanine and Their Oligomerization

Molar-Scale Synthesis of 1,2:5,6-Di-O-isopropylidene-α-d-allofuranose: DMSO Oxidation of 1,2:5,6-Di-O-isopropylidene-α-d-glucofuranose and Subsequent Sodium Borohydride Reduction

Effect of LNA Modifications on Small Molecule Binding to Nucleic Acids

New Standards in LNA Synthesis

Increased DNA binding and sequence discrimination of PNA oligomers containing 2,6-diaminopurine

Linker length in podophyllotoxin-acridine conjugates determines potency in vivo and in vitro as well as specificity against MDR cell lines

siRNA Versus Antisense Locked Nucleic Acids: Stay Single

SPC2996 - A New Bcl-2 Inhibitor for the Treatment of CLL

New compounds related to podophyllotoxin and congeners: synthesis, structure elucidation and biological testing

Improvements in automated PNA synthesis using Boc/Z monomers

Inhibition of PNA triplex formation by N4-benzoylated cytosine

6-Thioguanine in Peptide Nucleic Acids. Synthesis and Hybridization Properties

New Standards in LNA Synthesis

Nuclease Stability of LNA Oligonucleotides and LNA-DNA Chimeras

Thermal Chemistry of Podophyllotoxin in Ethanol and a Comparison of the Cytostatic Activity of the Thermolysis Products

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