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Fatty acid conjugation enhances potency of antisense oligonucleotides in muscle

Nucleic acids research, 2019-07, Vol.47 (12), p.6029-6044

2019

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Mechanisms of palmitic acid-conjugated antisense oligonucleotide distribution in mice

Nucleic acids research, 2020-05, Vol.48 (8), p.4382-4395

2020

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Characterizing the effect of GalNAc and phosphorothioate backbone on binding of antisense oligonucleotides to the asialoglycoprotein receptor

Nucleic acids research, 2017-03, Vol.45 (5), p.2294-2306

2017

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Efficient Synthesis and Biological Evaluation of 5′-GalNAc Conjugated Antisense Oligonucleotides

Bioconjugate chemistry, 2015-08, Vol.26 (8), p.1451-1455

2015

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Cross-species pharmacokinetic comparison from mouse to man of a second-generation antisense oligonucleotide, ISIS 301012, targeting human apolipoprotein B-100

Drug metabolism and disposition, 2007-03, Vol.35 (3), p.460-468

2007

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Pharmacokinetic and Pharmacodynamic Investigations of ION-353382, a Model Antisense Oligonucleotide: Using Alpha-2-Macroglobulin and Murinoglobulin Double-Knockout Mice

Nucleic acid therapeutics, 2016-08, Vol.26 (4), p.223-235

2016

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Elucidation of the Biotransformation Pathways of a Galnac3-conjugated Antisense Oligonucleotide in Rats and Monkeys

Molecular therapy. Nucleic acids, 2016, Vol.5 (5), p.e319, Article e319

2016

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Characterization of the interactions of chemically-modified therapeutic nucleic acids with plasma proteins using a fluorescence polarization assay

Nucleic acids research, 2019-02, Vol.47 (3), p.1110-1122

2019

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Targeted Delivery of Antisense Oligonucleotides Using Neurotensin Peptides

Journal of medicinal chemistry, 2020-08, Vol.63 (15), p.8471-8484

2020

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Conjugation of hydrophobic moieties enhances potency of antisense oligonucleotides in the muscle of rodents and non-human primates

Nucleic acids research, 2019-07, Vol.47 (12), p.6045

2019

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Human Dicer Binds Short Single-strand and Double-strand RNA with High Affinity and Interacts with Different Regions of the Nucleic Acids

The Journal of biological chemistry, 2009-01, Vol.284 (4), p.2535-2548

2009

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Formation of the N(2)-acetyl-2,6-diaminopurine oligonucleotide impurity caused by acetyl capping

Bioorganic & medicinal chemistry letters, 2014-08, Vol.24 (15), p.3243-3246

2014

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Antisense Oligonucleotides Containing Conformationally Constrained 2′,4′-(N-Methoxy)aminomethylene and 2′,4′-Aminooxymethylene and 2′-O,4′-C-Aminomethylene Bridged Nucleoside Analogues Show Improved Potency in Animal Models

Journal of medicinal chemistry, 2010-02, Vol.53 (4), p.1636-1650

2010

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Formation of the N2-acetyl-2,6-diaminopurine oligonucleotide impurity caused by acetyl capping

Bioorganic & medicinal chemistry letters, 2014-08, Vol.24 (15), p.3243-3246

2014

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Negative Ionization Micro Electrospray Mass Spectrometry of Oligonucleotides and their Complexes

Rapid communications in mass spectrometry, 1996, Vol.10 (1), p.47-50

1996

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On-Line HPLC Electrospray Mass Spectrometry of Phosphorothioate Oligonucleotide Metabolites

Analytical chemistry (Washington), 1997-02, Vol.69 (3), p.313-319

1997

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Hepatic distribution of a phosphorothioate oligodeoxynucleotide within rodents following intravenous administration

Biochemical pharmacology, 2001-08, Vol.62 (3), p.297-306

2001

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Formation of 4,4′-dimethoxytrityl- C-phosphonate oligonucleotides

Bioorganic & medicinal chemistry letters, 2004-09, Vol.14 (18), p.4683-4690

2004

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Synthesis of Antisense Oligonucleotides: Replacement of 3H-1,2-Benzodithiol-3-one 1,1-Dioxide (Beaucage Reagent) with Phenylacetyl Disulfide (PADS) As Efficient Sulfurization Reagent: From Bench to Bulk Manufacture of Active Pharmaceutical Ingredient

Organic process research & development, 2000-05, Vol.4 (3), p.199-204

2000

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Solution Stability and Degradation Pathway of Deoxyribonucleoside Phosphoramidites in Acetonitrile

Nucleosides, nucleotides & nucleic acids, 2004-05, Vol.23 (5), p.767-775

2004

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Formation of the N super(2)-acetyl-2,6-diaminopurine oligonucleotide impurity caused by acetyl capping

Bioorganic & medicinal chemistry letters, 2014-08, Vol.24 (15), p.3243-3246

2014

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PHOSPHOROTHIOATE OLIGONUCLEOTIDE METABOLISM: CHARACTERIZATION OF THE “N+”-MER BY CE AND HPLC-ES/MS

Bioorganic & medicinal chemistry letters, 1997-05, Vol.7 (10), p.1225-1230

1997

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Characterization of Oligonucleotide Metabolism In Vivo via Liquid Chromatography/Electrospray Tandem Mass Spectrometry with a Quadrupole Ion Trap Mass Spectrometer

Journal of mass spectrometry., 1997-03, Vol.32 (3), p.305-313

1997

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Hepatic distribution of a phosphorothioate oligodeoxynucleotide within rodents following intravenous administration212Abbreviations: HSV, herpes simplex virus; CGE, capillary gel electrophoresis; and HPLC/ES-MS, high performance liquid chromatography/electrospray-mass spectrometry.1Johnston J, ISIS Pharmaceuticals, personal communication. Cited with permission

Biochemical pharmacology, 2001-08, Vol.62 (3), p.297-306

2001

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Rapid deconvolution of combinatorial libraries using HPLC fractionation

Tetrahedron, 1998-04, Vol.54 (16), p.4067-4076

1998

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Fatty acid conjugation enhances potency of antisense oligonucleotides in muscle

Mechanisms of palmitic acid-conjugated antisense oligonucleotide distribution in mice

Characterizing the effect of GalNAc and phosphorothioate backbone on binding of antisense oligonucleotides to the asialoglycoprotein receptor

Efficient Synthesis and Biological Evaluation of 5′-GalNAc Conjugated Antisense Oligonucleotides

Cross-species pharmacokinetic comparison from mouse to man of a second-generation antisense oligonucleotide, ISIS 301012, targeting human apolipoprotein B-100

Pharmacokinetic and Pharmacodynamic Investigations of ION-353382, a Model Antisense Oligonucleotide: Using Alpha-2-Macroglobulin and Murinoglobulin Double-Knockout Mice

Elucidation of the Biotransformation Pathways of a Galnac3-conjugated Antisense Oligonucleotide in Rats and Monkeys

Characterization of the interactions of chemically-modified therapeutic nucleic acids with plasma proteins using a fluorescence polarization assay

Targeted Delivery of Antisense Oligonucleotides Using Neurotensin Peptides

Conjugation of hydrophobic moieties enhances potency of antisense oligonucleotides in the muscle of rodents and non-human primates

Human Dicer Binds Short Single-strand and Double-strand RNA with High Affinity and Interacts with Different Regions of the Nucleic Acids

Formation of the N(2)-acetyl-2,6-diaminopurine oligonucleotide impurity caused by acetyl capping

Antisense Oligonucleotides Containing Conformationally Constrained 2′,4′-(N-Methoxy)aminomethylene and 2′,4′-Aminooxymethylene and 2′-O,4′-C-Aminomethylene Bridged Nucleoside Analogues Show Improved Potency in Animal Models

Formation of the N2-acetyl-2,6-diaminopurine oligonucleotide impurity caused by acetyl capping

Negative Ionization Micro Electrospray Mass Spectrometry of Oligonucleotides and their Complexes

On-Line HPLC Electrospray Mass Spectrometry of Phosphorothioate Oligonucleotide Metabolites

Hepatic distribution of a phosphorothioate oligodeoxynucleotide within rodents following intravenous administration

Formation of 4,4′-dimethoxytrityl- C-phosphonate oligonucleotides

Synthesis of Antisense Oligonucleotides: Replacement of 3H-1,2-Benzodithiol-3-one 1,1-Dioxide (Beaucage Reagent) with Phenylacetyl Disulfide (PADS) As Efficient Sulfurization Reagent: From Bench to Bulk Manufacture of Active Pharmaceutical Ingredient

Solution Stability and Degradation Pathway of Deoxyribonucleoside Phosphoramidites in Acetonitrile

Formation of the N super(2)-acetyl-2,6-diaminopurine oligonucleotide impurity caused by acetyl capping

PHOSPHOROTHIOATE OLIGONUCLEOTIDE METABOLISM: CHARACTERIZATION OF THE “N+”-MER BY CE AND HPLC-ES/MS

Characterization of Oligonucleotide Metabolism In Vivo via Liquid Chromatography/Electrospray Tandem Mass Spectrometry with a Quadrupole Ion Trap Mass Spectrometer

Rapid deconvolution of combinatorial libraries using HPLC fractionation

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