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Interplay of metabolism and transport in determining oral drug absorption and gut wall metabolism: a simulation assessment using the "Advanced Dissolution, Absorption, Metabolism (ADAM)" model

Current drug metabolism, 2010-11, Vol.11 (9), p.716-729

2010

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Meta-analysis of the turnover of intestinal epithelia in preclinical animal species and humans

Drug metabolism and disposition, 2014-12, Vol.42 (12), p.2016-2022

2014

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Model-Informed Precision Dosing: Background, Requirements, Validation, Implementation, and Forward Trajectory of Individualizing Drug Therapy

Annual review of pharmacology and toxicology, 2021-01, Vol.61 (1), p.225-245

2021

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Diagnosing an overcrowded emergency department from its Electronic Health Records

Scientific reports, 2024-04, Vol.14 (1), p.9955-9955, Article 9955

2024

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The Impact of Formulation, Delivery, and Dosing Regimen on the Risk of Drug–Drug Interactions

Clinical pharmacology and therapeutics, 2019-06, Vol.105 (6), p.1329-1331

2019

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Early experience with the ARTISENTIAL® articulated instruments in laparoscopic low anterior resection with TME

Techniques in coloproctology, 2022-05, Vol.26 (5), p.373-386

2022

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Exploring the discrepancies between clinical trials and real‐world data: A small‐cell lung cancer study

Clinical and translational science, 2024-08, Vol.17 (8), p.e13909-n/a

2024

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The Pharmacokinetics of the CYP3A Substrate Midazolam in Morbidly Obese Patients Before and One Year After Bariatric Surgery

Pharmaceutical research, 2015-12, Vol.32 (12), p.3927-3936

2015

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Deconvolution and IVIVC: Exploring the Role of Rate-Limiting Conditions

The AAPS journal, 2016-03, Vol.18 (2), p.321-332

2016

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A novel analytical framework for risk stratification of real‐world data using machine learning: A small cell lung cancer study

Clinical and translational science, 2022-10, Vol.15 (10), p.2437-2447

2022

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Investigating the Connections Between Delivery of Care, Reablement, Workload, and Organizational Factors in Home Care Services: Mixed Methods Study

JMIR human factors, 2023-01, Vol.10, p.e42283-e42283

2023

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Population Pharmacokinetic Analysis and Simulation of Alternative Dosing Regimens for Biosimilars to Adalimumab and Etanercept in Patients with Rheumatoid Arthritis

Pharmaceutics, 2024-05, Vol.16 (6), p.702

2024

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Application of the Nested Enzyme‐Within‐Enterocyte (NEWE) Turnover Model for Predicting the Time Course of Pharmacodynamic Effects

CPT: pharmacometrics and systems pharmacology, 2020-11, Vol.9 (11), p.617-627

2020

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Application of Process Mining for Modelling Small Cell Lung Cancer Prognosis

Studies in health technology and informatics, 2023-05, Vol.302, p.18

2023

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Nanobubble and nanodroplet template growth of particle nanorings versus nanoholes in drying nanofluids and polymer films

Nanoscale, 2011-01, Vol.3 (3), p.1211-1217

2011

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Review article: time to revisit Child‐Pugh score as the basis for predicting drug clearance in hepatic impairment

Alimentary pharmacology & therapeutics, 2021-08, Vol.54 (4), p.388-401

2021

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A latent variable approach to account for correlated inputs in global sensitivity analysis

Journal of pharmacokinetics and pharmacodynamics, 2021-10, Vol.48 (5), p.671-686

2021

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Virtual bioequivalence for achlorhydric subjects: The use of PBPK modelling to assess the formulation-dependent effect of achlorhydria

European journal of pharmaceutical sciences, 2017-11, Vol.109, p.111-120

2017

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Towards Further Verification of Physiologically-Based Kidney Models: Predictability of the Effects of Urine-Flow and Urine-pH on Renal Clearance

The Journal of pharmacology and experimental therapeutics, 2019-02, Vol.368 (2), p.157-168

2019

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Why Has Model‐Informed Precision Dosing Not Yet Become Common Clinical Reality? Lessons From the Past and a Roadmap for the Future

Clinical pharmacology and therapeutics, 2017-05, Vol.101 (5), p.646-656

2017

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The nested enzyme-within-enterocyte (NEWE) turnover model for predicting dynamic drug and disease effects on the gut wall

European journal of pharmaceutical sciences, 2019-04, Vol.131, p.195-207

2019

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Physiologically Based Pharmacokinetic Modeling of Transporter-Mediated Hepatic Disposition of Imaging Biomarker Gadoxetate in Rats

Molecular pharmaceutics, 2021-08, Vol.18 (8), p.2997-3009

2021

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Global Sensitivity Analysis of the Rodgers and Rowland Model for Prediction of Tissue: Plasma Partitioning Coefficients: Assessment of the Key Physiological and Physicochemical Factors That Determine Small-Molecule Tissue Distribution

The AAPS journal, 2020-02, Vol.22 (2), p.41, Article 41

2020

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Accounting for inter-correlation between enzyme abundance: a simulation study to assess implications on global sensitivity analysis within physiologically-based pharmacokinetics

Journal of pharmacokinetics and pharmacodynamics, 2019-04, Vol.46 (2), p.137-154

2019

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Using Prior Knowledge on Systems Through PBPK to Gain Further Insight into Routine Clinical Data on Trough Concentrations: The Case of Tacrolimus in Chronic Kidney Disease

Therapeutic drug monitoring, 2023-12, Vol.45 (6), p.743

2023

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Interplay of metabolism and transport in determining oral drug absorption and gut wall metabolism: a simulation assessment using the "Advanced Dissolution, Absorption, Metabolism (ADAM)" model

Meta-analysis of the turnover of intestinal epithelia in preclinical animal species and humans

Model-Informed Precision Dosing: Background, Requirements, Validation, Implementation, and Forward Trajectory of Individualizing Drug Therapy

Diagnosing an overcrowded emergency department from its Electronic Health Records

The Impact of Formulation, Delivery, and Dosing Regimen on the Risk of Drug–Drug Interactions

Early experience with the ARTISENTIAL® articulated instruments in laparoscopic low anterior resection with TME

Exploring the discrepancies between clinical trials and real‐world data: A small‐cell lung cancer study

The Pharmacokinetics of the CYP3A Substrate Midazolam in Morbidly Obese Patients Before and One Year After Bariatric Surgery

Deconvolution and IVIVC: Exploring the Role of Rate-Limiting Conditions

A novel analytical framework for risk stratification of real‐world data using machine learning: A small cell lung cancer study

Investigating the Connections Between Delivery of Care, Reablement, Workload, and Organizational Factors in Home Care Services: Mixed Methods Study

Population Pharmacokinetic Analysis and Simulation of Alternative Dosing Regimens for Biosimilars to Adalimumab and Etanercept in Patients with Rheumatoid Arthritis

Application of the Nested Enzyme‐Within‐Enterocyte (NEWE) Turnover Model for Predicting the Time Course of Pharmacodynamic Effects

Application of Process Mining for Modelling Small Cell Lung Cancer Prognosis

Nanobubble and nanodroplet template growth of particle nanorings versus nanoholes in drying nanofluids and polymer films

Review article: time to revisit Child‐Pugh score as the basis for predicting drug clearance in hepatic impairment

A latent variable approach to account for correlated inputs in global sensitivity analysis

Virtual bioequivalence for achlorhydric subjects: The use of PBPK modelling to assess the formulation-dependent effect of achlorhydria

Towards Further Verification of Physiologically-Based Kidney Models: Predictability of the Effects of Urine-Flow and Urine-pH on Renal Clearance

Why Has Model‐Informed Precision Dosing Not Yet Become Common Clinical Reality? Lessons From the Past and a Roadmap for the Future

The nested enzyme-within-enterocyte (NEWE) turnover model for predicting dynamic drug and disease effects on the gut wall

Physiologically Based Pharmacokinetic Modeling of Transporter-Mediated Hepatic Disposition of Imaging Biomarker Gadoxetate in Rats

Global Sensitivity Analysis of the Rodgers and Rowland Model for Prediction of Tissue: Plasma Partitioning Coefficients: Assessment of the Key Physiological and Physicochemical Factors That Determine Small-Molecule Tissue Distribution

Accounting for inter-correlation between enzyme abundance: a simulation study to assess implications on global sensitivity analysis within physiologically-based pharmacokinetics

Using Prior Knowledge on Systems Through PBPK to Gain Further Insight into Routine Clinical Data on Trough Concentrations: The Case of Tacrolimus in Chronic Kidney Disease

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