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Alternatives to antibiotics—a pipeline portfolio review

The Lancet infectious diseases, 2016-02, Vol.16 (2), p.239-251

2016

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Modic changes as seen on MRI are associated with nonspecific chronic lower back pain and disability

Journal of orthopaedic surgery and research, 2023-05, Vol.18 (1), p.351-351, Article 351

2023

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Multiple effects of benzamide antibiotics on FtsZ function

Molecular microbiology, 2011-04, Vol.80 (1), p.68-84

2011

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Letter to the Editor concerning “Prospective study using anterior approach did not show association between Modic 1 changes and low-grade infection in lumbar spine” by Rigal J, Thelen T, Byrne F, Cogniet A, Boissière L, Aunoble S, Le Huec JC (Eur Spine J [2016]; 25(4):1000–5. doi: 10.1007/s00586-016-4396-5)

European spine journal, 2016-10, Vol.25 (10), p.3379-3380

Czaplewski, Lloyd G.

2016

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Chronic low back pain, bacterial infection and treatment with antibiotics

The spine journal, 2021-06, Vol.21 (6), p.903-914

2021

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An Improved Small-Molecule Inhibitor of FtsZ with Superior In Vitro Potency, Drug-Like Properties, and In Vivo Efficacy

Antimicrobial Agents and Chemotherapy, 2013-01, Vol.57 (1), p.317-325

2013

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Pyridine-3-carboxamide-6-yl-ureas as novel inhibitors of bacterial DNA gyrase: Structure based design, synthesis, SAR and antimicrobial activity

European journal of medicinal chemistry, 2014-10, Vol.86, p.31-38

2014

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Design, synthesis and structure-activity relationships of substituted oxazole-benzamide antibacterial inhibitors of FtsZ

Bioorganic & medicinal chemistry letters, 2014-01, Vol.24 (1), p.353-359

2014

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Reply to a letter to the editor regarding the article, “Chronic low back pain, bacterial infection and treatment with antibiotics. Gilligan CJ, Cohen SP, Fischetti VA, Hirsch JA, Czaplewski LG. Spine J 2021 Feb 18;S1529-9430”

The spine journal, 2021-07, Vol.21 (7), p.1236-1237

2021

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Inhibitor of FtsZ with Potent and Selective Anti-Staphylococcal Activity

Science (American Association for the Advancement of Science), 2008-09, Vol.321 (5896), p.1673-1675

2008

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Treatment of health-care-associated infections caused by Gram-negative bacteria: a consensus statement

The Lancet infectious diseases, 2008-02, Vol.8 (2), p.133-139

2008

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Biological Evaluation of Benzothiazole Ethyl Urea Inhibitors of Bacterial Type II Topoisomerases

Antimicrobial Agents and Chemotherapy, 2013-12, Vol.57 (12), p.5977-5986

2013

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Antibacterial alkoxybenzamide inhibitors of the essential bacterial cell division protein FtsZ

Bioorganic & medicinal chemistry letters, 2009-01, Vol.19 (2), p.524-527

2009

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Novel Inhibitors of Bacterial Cytokinesis Identified by a Cell-based Antibiotic Screening Assay

The Journal of biological chemistry, 2005-12, Vol.280 (48), p.39709-39715

2005

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Design, synthesis and biological evaluation of α-substituted isonipecotic acid benzothiazole analogues as potent bacterial type II topoisomerase inhibitors

Bioorganic & medicinal chemistry letters, 2013-12, Vol.23 (24), p.6598-6603

2013

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Discovery and development of new antibacterial drugs: learning from experience?

Journal of antimicrobial chemotherapy, 2018-06, Vol.73 (6), p.1452-1459

2018

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DNA gyrase (GyrB)/topoisomerase IV (ParE) inhibitors: Synthesis and antibacterial activity

Bioorganic & medicinal chemistry letters, 2009-02, Vol.19 (3), p.894-899

2009

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Essential Bacterial Functions Encoded by Gene Pairs

Journal of Bacteriology, 2007-01, Vol.189 (2), p.591-602

2007

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Analysis of the Clinical Pipeline of Treatments for Drug-Resistant Bacterial Infections: Despite Progress, More Action Is Needed

Antimicrobial agents and chemotherapy, 2022-03, Vol.66 (3), p.e0199121-e0199121

2022

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Analysis of the clinical antibacterial and antituberculosis pipeline

The Lancet infectious diseases, 2019-02, Vol.19 (2), p.e40-e50

2019

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The CC-Chemokine RANTES Increases the Attachment of Human Immunodeficiency Virus Type 1 to Target Cells via Glycosaminoglycans and Also Activates a Signal Transduction Pathway That Enhances Viral Infectivity

Journal of Virology, 1999-08, Vol.73 (8), p.6370-6379

1999

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The urgent need for new antibacterial agents

Journal of antimicrobial chemotherapy, 2011-09, Vol.66 (9), p.1939-1940

Wise, Richard

2011

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Reply to a letter to the editor regarding “Chronic low back pain, bacterial infection and treatment with antibiotics”

The spine journal, 2021-07, Vol.21 (7), p.1231-1232

2021

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Intradiscal pharmacokinetics of oral antibiotics to treat Chronic Lower Back Pain

NPJ ANTIMICROBIALS AND RESISTANCE, 2023-05, Vol.1 (1), Article 1

2023

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Evaluation of a Library of FDA-Approved Drugs for Their Ability To Potentiate Antibiotics against Multidrug-Resistant Gram-Negative Pathogens

Antimicrobial agents and chemotherapy, 2019-08, Vol.63 (8)

2019

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Alternatives to antibiotics—a pipeline portfolio review

Modic changes as seen on MRI are associated with nonspecific chronic lower back pain and disability

Multiple effects of benzamide antibiotics on FtsZ function

Chronic low back pain, bacterial infection and treatment with antibiotics

An Improved Small-Molecule Inhibitor of FtsZ with Superior In Vitro Potency, Drug-Like Properties, and In Vivo Efficacy

Pyridine-3-carboxamide-6-yl-ureas as novel inhibitors of bacterial DNA gyrase: Structure based design, synthesis, SAR and antimicrobial activity

Design, synthesis and structure-activity relationships of substituted oxazole-benzamide antibacterial inhibitors of FtsZ

Reply to a letter to the editor regarding the article, “Chronic low back pain, bacterial infection and treatment with antibiotics. Gilligan CJ, Cohen SP, Fischetti VA, Hirsch JA, Czaplewski LG. Spine J 2021 Feb 18;S1529-9430”

Inhibitor of FtsZ with Potent and Selective Anti-Staphylococcal Activity

Treatment of health-care-associated infections caused by Gram-negative bacteria: a consensus statement

Biological Evaluation of Benzothiazole Ethyl Urea Inhibitors of Bacterial Type II Topoisomerases

Antibacterial alkoxybenzamide inhibitors of the essential bacterial cell division protein FtsZ

Novel Inhibitors of Bacterial Cytokinesis Identified by a Cell-based Antibiotic Screening Assay

Design, synthesis and biological evaluation of α-substituted isonipecotic acid benzothiazole analogues as potent bacterial type II topoisomerase inhibitors

Discovery and development of new antibacterial drugs: learning from experience?

DNA gyrase (GyrB)/topoisomerase IV (ParE) inhibitors: Synthesis and antibacterial activity

Essential Bacterial Functions Encoded by Gene Pairs

Analysis of the Clinical Pipeline of Treatments for Drug-Resistant Bacterial Infections: Despite Progress, More Action Is Needed

Analysis of the clinical antibacterial and antituberculosis pipeline

The CC-Chemokine RANTES Increases the Attachment of Human Immunodeficiency Virus Type 1 to Target Cells via Glycosaminoglycans and Also Activates a Signal Transduction Pathway That Enhances Viral Infectivity

The urgent need for new antibacterial agents

Reply to a letter to the editor regarding “Chronic low back pain, bacterial infection and treatment with antibiotics”

Intradiscal pharmacokinetics of oral antibiotics to treat Chronic Lower Back Pain

Evaluation of a Library of FDA-Approved Drugs for Their Ability To Potentiate Antibiotics against Multidrug-Resistant Gram-Negative Pathogens

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