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A Review on Drug‐Induced Nephrotoxicity: Pathophysiological Mechanisms, Drug Classes, Clinical Management, and Recent Advances in Mathematical Modeling and Simulation Approaches

Clinical pharmacology in drug development, 2020-11, Vol.9 (8), p.896-909

2020

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Evaluating the Clinical Impact of Formulation Variability: A Metoprolol Extended‐Release Case Study

Journal of clinical pharmacology, 2019-09, Vol.59 (9), p.1266-1274

2019

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Population pharmacokinetic modeling of sotatercept in healthy participants and patients with pulmonary arterial hypertension

CPT: pharmacometrics and systems pharmacology, 2024-08, Vol.13 (8), p.1380-1393

2024

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Population pharmacokinetic analysis of the P2X3‐receptor antagonist gefapixant

CPT: pharmacometrics and systems pharmacology, 2023-08, Vol.12 (8), p.1107-1118

2023

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In vitro to clinical translational pharmacokinetic/pharmacodynamic modeling of doxorubicin (DOX) and dexrazoxane (DEX) interactions: Safety assessment and optimization

Scientific reports, 2023-02, Vol.13 (1), p.3100-3100, Article 3100

2023

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The Impact of Immunogenicity on the Pharmacokinetics, Efficacy, and Safety of Sotatercept in a Phase III Study of Pulmonary Arterial Hypertension

Clinical pharmacology and therapeutics, 2024-03, Vol.115 (3), p.478-487

2024

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Subcutaneous Biologics: Clinical Pharmacology and Drug Development

Clinical pharmacology and therapeutics, 2024-03, Vol.115 (3), p.385-390

2024

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Dosing Strategies and Quantitative Clinical Pharmacology for Bispecific T‐Cell Engagers Development in Oncology

Clinical pharmacology and therapeutics, 2024-09, Vol.116 (3), p.637-646

2024

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Experimental and computational assessment of the synergistic pharmacodynamic drug–drug interactions of a triple combination therapy in refractory HER2-positive breast cancer cells

Journal of pharmacokinetics and pharmacodynamics, 2022-04, Vol.49 (2), p.227-241

2022

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Application of pharmacometrics and quantitative systems pharmacology to cancer therapy: The example of luminal a breast cancer

Pharmacological research, 2017-10, Vol.124, p.20-33

2017

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Challenging the Norm: A Multidisciplinary Perspective on Intravenous to Subcutaneous Bridging Strategies for Biologics

Clinical pharmacology and therapeutics, 2024-03, Vol.115 (3), p.412-421

2024

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In vitro to clinical translation of combinatorial effects of doxorubicin and dexrazoxane in breast cancer: a mechanism-based pharmacokinetic/pharmacodynamic modeling approach

Frontiers in pharmacology, 2023-10, Vol.14, p.1239141-1239141

2023

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A Mechanism-Based PK/PD Model for Hematological Toxicities Induced by Antibody-Drug Conjugates

The AAPS journal, 2017-09, Vol.19 (5), p.1436-1448

2017

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A quantitative systems pharmacological approach identified activation of JNK signaling pathway as a promising treatment strategy for refractory HER2 positive breast cancer

Journal of pharmacokinetics and pharmacodynamics, 2021-04, Vol.48 (2), p.273-293

2021

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Expansion of the neonatal platelet mass is achieved via an extension of platelet lifespan

Blood, 2014-05, Vol.123 (22), p.3381-3389

2014

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Pharmacodynamic Modeling to Evaluate the Impact of Cimetidine, an OCT2 Inhibitor, on the Anticancer Effects of Cisplatin

Cells (Basel, Switzerland), 2022-12, Vol.12 (1), p.57

2022

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Pharmacodynamic Modeling of Cell Cycle Effects for Gemcitabine and Trabectedin Combinations in Pancreatic Cancer Cells

Frontiers in pharmacology, 2016-11, Vol.7, p.421-421

2016

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Application of pharmacokinetic and pharmacodynamic analysis to the development of liposomal formulations for oncology

Pharmaceutics, 2014-03, Vol.6 (1), p.137-174

2014

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Utility of a Novel Three-Dimensional and Dynamic (3DD) Cell Culture System for PK/PD Studies: Evaluation of a Triple Combination Therapy at Overcoming Anti-HER2 Treatment Resistance in Breast Cancer

Frontiers in pharmacology, 2018-05, Vol.9, p.403-403

2018

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Simultaneous pharmacokinetics/pharmacodynamics modeling of recombinant human erythropoietin upon multiple intravenous dosing in rats

The Journal of pharmacology and experimental therapeutics, 2010-09, Vol.334 (3), p.897-910

2010

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Non-linear mixed effect modeling of the time-variant disposition of erythropoietin in anemic cancer patients

Biopharmaceutics & drug disposition, 2011-01, Vol.32 (1), p.1-15

2011

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Fourteenth American Conference on Pharmacometrics (ACoP14) – Innovation and Diversity: Redefining Pharmacometrics

Journal of pharmacokinetics and pharmacodynamics, 2024-04, Vol.51 (2), p.95-100

Ait-Oudhia, Sihem

2024

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Flow cytometric analysis of reticulocyte maturation after erythropoietin administration in rats

Cytometry. Part A, 2009-07, Vol.75A (7), p.584-592

2009

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Insights into Doxorubicin-induced Cardiotoxicity: Molecular Mechanisms, Preventive Strategies, and Early Monitoring

Molecular pharmacology, 2019-08, Vol.96 (2), p.219-232

2019

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Mechanisms, monitoring, and management of tyrosine kinase inhibitors-associated cardiovascular toxicities

OncoTargets and therapy, 2018-01, Vol.11, p.6227-6237

2018

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A Review on Drug‐Induced Nephrotoxicity: Pathophysiological Mechanisms, Drug Classes, Clinical Management, and Recent Advances in Mathematical Modeling and Simulation Approaches

Evaluating the Clinical Impact of Formulation Variability: A Metoprolol Extended‐Release Case Study

Population pharmacokinetic modeling of sotatercept in healthy participants and patients with pulmonary arterial hypertension

Population pharmacokinetic analysis of the P2X3‐receptor antagonist gefapixant

In vitro to clinical translational pharmacokinetic/pharmacodynamic modeling of doxorubicin (DOX) and dexrazoxane (DEX) interactions: Safety assessment and optimization

The Impact of Immunogenicity on the Pharmacokinetics, Efficacy, and Safety of Sotatercept in a Phase III Study of Pulmonary Arterial Hypertension

Subcutaneous Biologics: Clinical Pharmacology and Drug Development

Dosing Strategies and Quantitative Clinical Pharmacology for Bispecific T‐Cell Engagers Development in Oncology

Experimental and computational assessment of the synergistic pharmacodynamic drug–drug interactions of a triple combination therapy in refractory HER2-positive breast cancer cells

Application of pharmacometrics and quantitative systems pharmacology to cancer therapy: The example of luminal a breast cancer

Challenging the Norm: A Multidisciplinary Perspective on Intravenous to Subcutaneous Bridging Strategies for Biologics

In vitro to clinical translation of combinatorial effects of doxorubicin and dexrazoxane in breast cancer: a mechanism-based pharmacokinetic/pharmacodynamic modeling approach

A Mechanism-Based PK/PD Model for Hematological Toxicities Induced by Antibody-Drug Conjugates

A quantitative systems pharmacological approach identified activation of JNK signaling pathway as a promising treatment strategy for refractory HER2 positive breast cancer

Expansion of the neonatal platelet mass is achieved via an extension of platelet lifespan

Pharmacodynamic Modeling to Evaluate the Impact of Cimetidine, an OCT2 Inhibitor, on the Anticancer Effects of Cisplatin

Pharmacodynamic Modeling of Cell Cycle Effects for Gemcitabine and Trabectedin Combinations in Pancreatic Cancer Cells

Application of pharmacokinetic and pharmacodynamic analysis to the development of liposomal formulations for oncology

Utility of a Novel Three-Dimensional and Dynamic (3DD) Cell Culture System for PK/PD Studies: Evaluation of a Triple Combination Therapy at Overcoming Anti-HER2 Treatment Resistance in Breast Cancer

Simultaneous pharmacokinetics/pharmacodynamics modeling of recombinant human erythropoietin upon multiple intravenous dosing in rats

Non-linear mixed effect modeling of the time-variant disposition of erythropoietin in anemic cancer patients

Fourteenth American Conference on Pharmacometrics (ACoP14) – Innovation and Diversity: Redefining Pharmacometrics

Flow cytometric analysis of reticulocyte maturation after erythropoietin administration in rats

Insights into Doxorubicin-induced Cardiotoxicity: Molecular Mechanisms, Preventive Strategies, and Early Monitoring

Mechanisms, monitoring, and management of tyrosine kinase inhibitors-associated cardiovascular toxicities

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