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Focused Ultrasound-mediated Drug Delivery in Humans – a Path Towards Translation in Neurodegenerative Diseases

Pharmaceutical research, 2022-03, Vol.39 (3), p.427-439

2022

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Oxidative Stress in Neurodegenerative Diseases: From a Mitochondrial Point of View

Oxidative medicine and cellular longevity, 2019-01, Vol.2019 (2019), p.1-18

2019

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Advances in the Development of Disease-Modifying Treatments for Amyotrophic Lateral Sclerosis

CNS drugs, 2016-03, Vol.30 (3), p.227-243

2016

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CuII(atsm) improves the neurological phenotype and survival of SOD1G93A mice and selectively increases enzymatically active SOD1 in the spinal cord

Scientific reports, 2017-02, Vol.7 (1), p.42292-42292, Article 42292

2017

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Altered Brain Endothelial Cell Phenotype from a Familial Alzheimer Mutation and Its Potential Implications for Amyloid Clearance and Drug Delivery

Stem cell reports, 2020-05, Vol.14 (5), p.924-939

2020

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Monoclonal antibodies inhibit prion replication and delay the development of prion disease

Nature (London), 2003-03, Vol.422 (6927), p.80-83

2003

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Conjugation of Transferrin to Azide-Modified CdSe/ZnS Core-Shell Quantum Dots using Cyclooctyne Click Chemistry

Angewandte Chemie (International ed.), 2012-10, Vol.51 (42), p.10523-10527

International ed. in English, 2012

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impaired mitochondrial electron transport chain increases retention of the hypoxia imaging agent diacetylbis(4-methylthiosemicarbazonato)copperII

Proceedings of the National Academy of Sciences - PNAS, 2012-01, Vol.109 (1), p.47-52

2012

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Inhibition of TDP-43 accumulation by bis(thiosemicarbazonato)-copper complexes

PloS one, 2012-08, Vol.7 (8), p.e42277

2012

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Diacetylbis(N(4)-methylthiosemicarbazonato) Copper(II) (CuII(atsm)) Protects against Peroxynitrite-induced Nitrosative Damage and Prolongs Survival in Amyotrophic Lateral Sclerosis Mouse Model

The Journal of biological chemistry, 2011-12, Vol.286 (51), p.44035-44044

2011

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Phosphorylation of hnRNP K by cyclin-dependent kinase 2 controls cytosolic accumulation of TDP-43

Human molecular genetics, 2015-03, Vol.24 (6), p.1655-1669

2015

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Enhancing survival motor neuron expression extends lifespan and attenuates neurodegeneration in mutant TDP-43 mice

Human molecular genetics, 2016-09, Vol.25 (18), p.4080-4093

2016

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Therapeutic effects of CuII(atsm) in the SOD1-G37R mouse model of amyotrophic lateral sclerosis

Amyotrophic lateral sclerosis and frontotemporal degeneration, 2013-12, Vol.14 (7-8), p.586-590

2013

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High Glucose-Induced ROS Production Stimulates Proliferation of Pancreatic Cancer via Inactivating the JNK Pathway

Oxidative medicine and cellular longevity, 2018-01, Vol.2018 (2018), p.1-10

2018

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C-Jun N-terminal kinase controls TDP-43 accumulation in stress granules induced by oxidative stress

Molecular neurodegeneration, 2011-08, Vol.6 (1), p.57-57, Article 57

2011

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Bis(thiosemicarbazonato) Cu-64 complexes for positron emission tomography imaging of Alzheimer's disease

Journal of Alzheimer's disease, 2010-01, Vol.20 (1), p.49-55

2010

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Copper and Zinc Binding Modulates the Aggregation and Neurotoxic Properties of the Prion Peptide PrP106−126

Biochemistry (Easton), 2001-07, Vol.40 (27), p.8073-8084

2001

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Manganese chelation therapy extends survival in a mouse model of M1000 prion disease

Journal of neurochemistry, 2010-07, Vol.114 (2), p.440-451

2010

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Copper levels are increased in the cerebral cortex and liver of APP and APLP2 knockout mice

Brain research, 1999-09, Vol.842 (2), p.439-444

1999

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Deregulation of subcellular biometal homeostasis through loss of the metal transporter, Zip7, in a childhood neurodegenerative disorder

Acta neuropathologica communications, 2014-02, Vol.2 (1), p.25-25, Article 25

2014

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Neurotoxicity from glutathione depletion is dependent on extracellular trace copper

Journal of neuroscience research, 2003-03, Vol.71 (6), p.889-897

2003

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The Alzheimer's Disease Amyloid Precursor Protein Modulates Copper-Induced Toxicity and Oxidative Stress in Primary Neuronal Cultures

The Journal of neuroscience, 1999-11, Vol.19 (21), p.9170-9179

1999

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Prion Protein-Deficient Neurons Reveal Lower Glutathione Reductase Activity and Increased Susceptibility to Hydrogen Peroxide Toxicity

The American journal of pathology, 1999-11, Vol.155 (5), p.1723-1730

1999

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The role of metals in modulating metalloprotease activity in the AD brain

European biophysics journal, 2008-03, Vol.37 (3), p.315-321

2008

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Cell cycle arrest in cultured neuroblastoma cells exposed to a bis(thiosemicarbazonato) metal complex

Biometals, 2011-02, Vol.24 (1), p.117-133

2011

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Focused Ultrasound-mediated Drug Delivery in Humans – a Path Towards Translation in Neurodegenerative Diseases

Oxidative Stress in Neurodegenerative Diseases: From a Mitochondrial Point of View

Advances in the Development of Disease-Modifying Treatments for Amyotrophic Lateral Sclerosis

CuII(atsm) improves the neurological phenotype and survival of SOD1G93A mice and selectively increases enzymatically active SOD1 in the spinal cord

Altered Brain Endothelial Cell Phenotype from a Familial Alzheimer Mutation and Its Potential Implications for Amyloid Clearance and Drug Delivery

Monoclonal antibodies inhibit prion replication and delay the development of prion disease

Conjugation of Transferrin to Azide-Modified CdSe/ZnS Core-Shell Quantum Dots using Cyclooctyne Click Chemistry

impaired mitochondrial electron transport chain increases retention of the hypoxia imaging agent diacetylbis(4-methylthiosemicarbazonato)copperII

Inhibition of TDP-43 accumulation by bis(thiosemicarbazonato)-copper complexes

Diacetylbis(N(4)-methylthiosemicarbazonato) Copper(II) (CuII(atsm)) Protects against Peroxynitrite-induced Nitrosative Damage and Prolongs Survival in Amyotrophic Lateral Sclerosis Mouse Model

Phosphorylation of hnRNP K by cyclin-dependent kinase 2 controls cytosolic accumulation of TDP-43

Enhancing survival motor neuron expression extends lifespan and attenuates neurodegeneration in mutant TDP-43 mice

Therapeutic effects of CuII(atsm) in the SOD1-G37R mouse model of amyotrophic lateral sclerosis

High Glucose-Induced ROS Production Stimulates Proliferation of Pancreatic Cancer via Inactivating the JNK Pathway

C-Jun N-terminal kinase controls TDP-43 accumulation in stress granules induced by oxidative stress

Bis(thiosemicarbazonato) Cu-64 complexes for positron emission tomography imaging of Alzheimer's disease

Copper and Zinc Binding Modulates the Aggregation and Neurotoxic Properties of the Prion Peptide PrP106−126

Manganese chelation therapy extends survival in a mouse model of M1000 prion disease

Copper levels are increased in the cerebral cortex and liver of APP and APLP2 knockout mice

Deregulation of subcellular biometal homeostasis through loss of the metal transporter, Zip7, in a childhood neurodegenerative disorder

Neurotoxicity from glutathione depletion is dependent on extracellular trace copper

The Alzheimer's Disease Amyloid Precursor Protein Modulates Copper-Induced Toxicity and Oxidative Stress in Primary Neuronal Cultures

Prion Protein-Deficient Neurons Reveal Lower Glutathione Reductase Activity and Increased Susceptibility to Hydrogen Peroxide Toxicity

The role of metals in modulating metalloprotease activity in the AD brain

Cell cycle arrest in cultured neuroblastoma cells exposed to a bis(thiosemicarbazonato) metal complex

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