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Dual-specificity MAP kinase phosphatases (MKPs) and cancer

Cancer and metastasis reviews, 2008-06, Vol.27 (2), p.253-261

Keyse, Stephen M.

2008

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Dual-specificity MAP kinase phosphatases in health and disease

Biochimica et biophysica acta. Molecular cell research, 2019-01, Vol.1866 (1), p.124-143

2019

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Diverse physiological functions for dual-specificity MAP kinase phosphatases

Journal of cell science, 2006-11, Vol.119 (22), p.4607-4615

2006

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Dual-specificity phosphatase 5 controls the localized inhibition, propagation, and transforming potential of ERK signaling

Proceedings of the National Academy of Sciences - PNAS, 2017-01, Vol.114 (3), p.E317-E326

2017

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Regulation of Caenorhabditis elegans p53/CEP-1-dependent germ cell apoptosis by Ras/MAPK signaling

PLoS genetics, 2011-08, Vol.7 (8), p.e1002238

2011

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Suppression of mutant Kirsten-RAS (KRAS G12D )-driven pancreatic carcinogenesis by dual-specificity MAP kinase phosphatases 5 and 6

Oncogene, 2022-05, Vol.41 (20), p.2811-2823

2022

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Heat Shock Factor 1 Is a Substrate for p38 Mitogen-Activated Protein Kinases

Molecular and cellular biology, 2016-09, Vol.36 (18), p.2403-2417

2016

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Dual-specificity phosphatase 5 regulates nuclear ERK activity and suppresses skin cancer by inhibiting mutant Harvey-Ras (HRasQ⁶¹ᴸ)-driven SerpinB2 expression

Proceedings of the National Academy of Sciences - PNAS, 2014-12, Vol.111 (51), p.18267-18272

2014

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Specific Inactivation and Nuclear Anchoring of Extracellular Signal-Regulated Kinase 2 by the Inducible Dual-Specificity Protein Phosphatase DUSP5

Molecular and Cellular Biology, 2005-03, Vol.25 (5), p.1830-1845

2005

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Regulation of the inducible nuclear dual-specificity phosphatase DUSP5 by ERK MAPK

Cellular signalling, 2009-12, Vol.21 (12), p.1794-1805

2009

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Both Nuclear-Cytoplasmic Shuttling of the Dual Specificity Phosphatase MKP-3 and Its Ability to Anchor MAP Kinase in the Cytoplasm Are Mediated by a Conserved Nuclear Export Signal

The Journal of biological chemistry, 2004-10, Vol.279 (40), p.41882-41891

2004

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Negative Feedback Regulation of FGF Signaling Levels by Pyst1/MKP3 in Chick Embryos

Current biology, 2003-06, Vol.13 (12), p.1009-1018

2003

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DUSP6/MKP-3 inactivates ERK1/2 but fails to bind and inactivate ERK5

Cellular signalling, 2008-05, Vol.20 (5), p.836-843

2008

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Activation of MK5/PRAK by the atypical MAP kinase ERK3 defines a novel signal transduction pathway

The EMBO journal, 2004-12, Vol.23 (24), p.4780-4791

2004

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Oxidative stress and heat shock induce a human gene encoding a protein-tyrosine phosphatase

Nature (London), 1992-10, Vol.359 (6396), p.644-647

1992

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Both Binding and Activation of p38 Mitogen-Activated Protein Kinase (MAPK) Play Essential Roles in Regulation of the Nucleocytoplasmic Distribution of MAPK-Activated Protein Kinase 5 by Cellular Stress

Molecular and Cellular Biology, 2002-10, Vol.22 (20), p.6931-6945

2002

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Dual‐specificity MAP kinase phosphatases (MKPs)

The FEBS journal, 2013-01, Vol.280 (2), p.489-504

2013

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Membrane Proximal ERK Signaling Is Required for M-calpain Activation Downstream of Epidermal Growth Factor Receptor Signaling

The Journal of biological chemistry, 2001-06, Vol.276 (26), p.23341-23348

2001

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An emerging family of dual specificity MAP kinase phosphatases

BBA - Molecular Cell Research, 1995-03, Vol.1265 (2), p.152-160

Keyse, Stephen M.

1995

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Protein phosphatases and the regulation of MAP kinase activity

Seminars in cell & developmental biology, 1998-04, Vol.9 (2), p.143-152

Keyse, Stephen M.

1998

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Crystal structure of the MAPK phosphatase Pyst1 catalytic domain and implications for regulated activation

Nature structural biology, 1999-02, Vol.6 (2), p.174-181

1999

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Differential regulation of the MAP, SAP and RK/p38 kinases by Pyst1, a novel cytosolic dual‐specificity phosphatase

The EMBO journal, 1996-07, Vol.15 (14), p.3621-3632

1996

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Induction of the heme oxygenase gene in human skin fibroblasts by hydrogen peroxide and UVA (365 nm) radiation: evidence for the involvement of the hydroxyl radical

Carcinogenesis (New York), 1990-05, Vol.11 (5), p.787-791

1990

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Heme Oxygenase is the Major 32-kDa Stress Protein Induced in Human Skin Fibroblasts by UVA Radiation, Hydrogen Peroxide, and Sodium Arsenite

Proceedings of the National Academy of Sciences - PNAS, 1989-01, Vol.86 (1), p.99-103

1989

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Oxidant stress leads to transcriptional activation of the human heme oxygenase gene in cultured skin fibroblasts

Molecular and Cellular Biology, 1990-09, Vol.10 (9), p.4967-4969

1990

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Dual-specificity MAP kinase phosphatases (MKPs) and cancer

Dual-specificity MAP kinase phosphatases in health and disease

Diverse physiological functions for dual-specificity MAP kinase phosphatases

Dual-specificity phosphatase 5 controls the localized inhibition, propagation, and transforming potential of ERK signaling

Regulation of Caenorhabditis elegans p53/CEP-1-dependent germ cell apoptosis by Ras/MAPK signaling

Suppression of mutant Kirsten-RAS (KRAS G12D )-driven pancreatic carcinogenesis by dual-specificity MAP kinase phosphatases 5 and 6

Heat Shock Factor 1 Is a Substrate for p38 Mitogen-Activated Protein Kinases

Dual-specificity phosphatase 5 regulates nuclear ERK activity and suppresses skin cancer by inhibiting mutant Harvey-Ras (HRasQ⁶¹ᴸ)-driven SerpinB2 expression

Specific Inactivation and Nuclear Anchoring of Extracellular Signal-Regulated Kinase 2 by the Inducible Dual-Specificity Protein Phosphatase DUSP5

Regulation of the inducible nuclear dual-specificity phosphatase DUSP5 by ERK MAPK

Both Nuclear-Cytoplasmic Shuttling of the Dual Specificity Phosphatase MKP-3 and Its Ability to Anchor MAP Kinase in the Cytoplasm Are Mediated by a Conserved Nuclear Export Signal

Negative Feedback Regulation of FGF Signaling Levels by Pyst1/MKP3 in Chick Embryos

DUSP6/MKP-3 inactivates ERK1/2 but fails to bind and inactivate ERK5

Activation of MK5/PRAK by the atypical MAP kinase ERK3 defines a novel signal transduction pathway

Oxidative stress and heat shock induce a human gene encoding a protein-tyrosine phosphatase

Both Binding and Activation of p38 Mitogen-Activated Protein Kinase (MAPK) Play Essential Roles in Regulation of the Nucleocytoplasmic Distribution of MAPK-Activated Protein Kinase 5 by Cellular Stress

Dual‐specificity MAP kinase phosphatases (MKPs)

Membrane Proximal ERK Signaling Is Required for M-calpain Activation Downstream of Epidermal Growth Factor Receptor Signaling

An emerging family of dual specificity MAP kinase phosphatases

Protein phosphatases and the regulation of MAP kinase activity

Crystal structure of the MAPK phosphatase Pyst1 catalytic domain and implications for regulated activation

Differential regulation of the MAP, SAP and RK/p38 kinases by Pyst1, a novel cytosolic dual‐specificity phosphatase

Induction of the heme oxygenase gene in human skin fibroblasts by hydrogen peroxide and UVA (365 nm) radiation: evidence for the involvement of the hydroxyl radical

Heme Oxygenase is the Major 32-kDa Stress Protein Induced in Human Skin Fibroblasts by UVA Radiation, Hydrogen Peroxide, and Sodium Arsenite

Oxidant stress leads to transcriptional activation of the human heme oxygenase gene in cultured skin fibroblasts

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