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Molecular mechanisms of cardiotoxicity of tyrosine kinase inhibition

Nature reviews. Cancer, 2007-05, Vol.7 (5), p.332-344

2007

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Loss of Ikaros DNA-binding function confers integrin-dependent survival on pre-B cells and progression to acute lymphoblastic leukemia

Nature immunology, 2014-03, Vol.15 (3), p.294

2014

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Molecular pathogenesis and therapy of polycythemia induced in mice by JAK2 V617F

PloS one, 2006-12, Vol.1 (1), p.e18-e18

2006

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Differential regulation of myeloid leukemias by the bone marrow microenvironment

Nature medicine, 2013-11, Vol.19 (11), p.1513-1517

2013

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Requirement for CD44 in homing and engraftment of BCR-ABL-expressing leukemic stem cells

Nature medicine, 2006-10, Vol.12 (10), p.1175-1180

2006

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Targeting autophagy potentiates tyrosine kinase inhibitor-induced cell death in Philadelphia chromosome-positive cells, including primary CML stem cells

The Journal of clinical investigation, 2009-05, Vol.119 (5), p.1109-1123

2009

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Cardiotoxicity of the cancer therapeutic agent imatinib mesylate

Nature medicine, 2006-08, Vol.12 (8), p.908-916

2006

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Superenhancer reprogramming drives a B-cell-epithelial transition and high-risk leukemia

Genes & development, 2016-09, Vol.30 (17), p.1971-1990

2016

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Alternative approaches to eradicating the malignant clone in chronic myeloid leukemia: tyrosine-kinase inhibitor combinations and beyond

Hematology, 2013, Vol.2013 (1), p.189-200

2013

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Peroxiredoxin1 Prevents Excessive Endothelial Activation and Early Atherosclerosis

Circulation research, 2008-09, Vol.103 (6), p.598-605

2008

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Oncogenic signaling: new insights and controversies from chronic myeloid leukemia

The Journal of experimental medicine, 2007-03, Vol.204 (3), p.461-465

Van Etten, Richard A

2007

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Autoinhibition of Bcr-Abl through Its SH3 Domain

Molecular cell, 2003-07, Vol.12 (1), p.27-37

2003

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Clinical Resistance to the Kinase Inhibitor STI-571 in Chronic Myeloid Leukemia by Mutation of Tyr-253 in the Abl Kinase Domain P-Loop

Proceedings of the National Academy of Sciences - PNAS, 2002-08, Vol.99 (16), p.10700-10705

2002

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Focus on myeloproliferative diseases and myelodysplastic syndromes

Cancer cell, 2004-12, Vol.6 (6), p.547-552

2004

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A Murine Model of CML Blast Crisis Induced by Cooperation between BCR/ABL and NUP98/HOXA9

Proceedings of the National Academy of Sciences - PNAS, 2002-05, Vol.99 (11), p.7622-7627

2002

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Distinct graft-versus-leukemic stem cell effects of early or delayed donor leukocyte infusions in a mouse chronic myeloid leukemia model

Blood, 2012-01, Vol.119 (1), p.273-284

2012

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Transformation of hematopoietic cell lines to growth-factor independence and induction of a fatal myelo- and lymphoproliferative disease in mice by retrovirally transduced TEL/JAK2 fusion genes

The EMBO journal, 1998-09, Vol.17 (18), p.5321-5333

1998

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The Ph-positive and Ph-negative myeloproliferative neoplasms: some topical pre-clinical and clinical issues

Haematologica (Roma), 2011-04, Vol.96 (4), p.590-601

2011

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Essential role for Stat5a/b in myeloproliferative neoplasms induced by BCR-ABL1 and JAK2V617F in mice

Blood, 2012-04, Vol.119 (15), p.3550-3560

2012

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Ubiquitous and uniform in vivo fluorescence in ROSA26-EGFP BAC transgenic mice

Genesis (New York, N.Y. : 2000), 2007-02, Vol.45 (2), p.83-89

2007

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A Direct Binding Site for Grb2 Contributes to Transformation and Leukemogenesis by the Tel-Abl (ETV6-Abl) Tyrosine Kinase

Molecular and Cellular Biology, 2004-06, Vol.24 (11), p.4685-4695

2004

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Cycling, stressed-out and nervous: cellular functions of c-Abl

Trends in Cell Biology, 1999-05, Vol.9 (5), p.179-186

Van Etten, Richard A.

1999

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The Tel-Abl (ETV6-Abl) tyrosine kinase, product of complex (9;12) translocations in human leukemia, induces distinct myeloproliferative disease in mice

Blood, 2002-06, Vol.99 (12), p.4568-4577

2002

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The P190, P210, and P230 forms of the BCR/ABL oncogene induce a similar chronic myeloid leukemia-like syndrome in mice but have different lymphoid leukemogenic activity

The Journal of experimental medicine, 1999-05, Vol.189 (9), p.1399-1412

1999

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P210 and P190(BCR/ABL) induce the tyrosine phosphorylation and DNA binding activity of multiple specific STAT family members

The Journal of biological chemistry, 1996-12, Vol.271 (49), p.31704-31710

1996

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Molecular mechanisms of cardiotoxicity of tyrosine kinase inhibition

Loss of Ikaros DNA-binding function confers integrin-dependent survival on pre-B cells and progression to acute lymphoblastic leukemia

Molecular pathogenesis and therapy of polycythemia induced in mice by JAK2 V617F

Differential regulation of myeloid leukemias by the bone marrow microenvironment

Requirement for CD44 in homing and engraftment of BCR-ABL-expressing leukemic stem cells

Targeting autophagy potentiates tyrosine kinase inhibitor-induced cell death in Philadelphia chromosome-positive cells, including primary CML stem cells

Cardiotoxicity of the cancer therapeutic agent imatinib mesylate

Superenhancer reprogramming drives a B-cell-epithelial transition and high-risk leukemia

Alternative approaches to eradicating the malignant clone in chronic myeloid leukemia: tyrosine-kinase inhibitor combinations and beyond

Peroxiredoxin1 Prevents Excessive Endothelial Activation and Early Atherosclerosis

Oncogenic signaling: new insights and controversies from chronic myeloid leukemia

Autoinhibition of Bcr-Abl through Its SH3 Domain

Clinical Resistance to the Kinase Inhibitor STI-571 in Chronic Myeloid Leukemia by Mutation of Tyr-253 in the Abl Kinase Domain P-Loop

Focus on myeloproliferative diseases and myelodysplastic syndromes

A Murine Model of CML Blast Crisis Induced by Cooperation between BCR/ABL and NUP98/HOXA9

Distinct graft-versus-leukemic stem cell effects of early or delayed donor leukocyte infusions in a mouse chronic myeloid leukemia model

Transformation of hematopoietic cell lines to growth-factor independence and induction of a fatal myelo- and lymphoproliferative disease in mice by retrovirally transduced TEL/JAK2 fusion genes

The Ph-positive and Ph-negative myeloproliferative neoplasms: some topical pre-clinical and clinical issues

Essential role for Stat5a/b in myeloproliferative neoplasms induced by BCR-ABL1 and JAK2V617F in mice

Ubiquitous and uniform in vivo fluorescence in ROSA26-EGFP BAC transgenic mice

A Direct Binding Site for Grb2 Contributes to Transformation and Leukemogenesis by the Tel-Abl (ETV6-Abl) Tyrosine Kinase

Cycling, stressed-out and nervous: cellular functions of c-Abl

The Tel-Abl (ETV6-Abl) tyrosine kinase, product of complex (9;12) translocations in human leukemia, induces distinct myeloproliferative disease in mice

The P190, P210, and P230 forms of the BCR/ABL oncogene induce a similar chronic myeloid leukemia-like syndrome in mice but have different lymphoid leukemogenic activity

P210 and P190(BCR/ABL) induce the tyrosine phosphorylation and DNA binding activity of multiple specific STAT family members

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